"Dithiothreitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
| Descriptor ID |
D004229
|
| MeSH Number(s) |
D02.033.800.196 D02.886.740.224 D09.853.196
|
| Concept/Terms |
Dithiothreitol- Dithiothreitol
- Cleland's Reagent
- Clelands Reagent
- Reagent, Cleland's
- Cleland Reagent
- Reagent, Cleland
|
Below are MeSH descriptors whose meaning is more general than "Dithiothreitol".
Below are MeSH descriptors whose meaning is more specific than "Dithiothreitol".
This graph shows the total number of publications written about "Dithiothreitol" by people in this website by year, and whether "Dithiothreitol" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dithiothreitol" by people in Profiles.
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Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2316-26.
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Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate. J Biol Chem. 2001 Mar 16; 276(11):8261-8.
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Nitric oxide and thiol reagent modulation of Ca2+-activated K+ (BKCa) channels in myocytes of the guinea-pig taenia caeci. J Physiol. 2000 Jun 01; 525 Pt 2:363-76.
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Cisplatin inhibits protein synthesis in rabbit reticulocyte lysate by causing an arrest in elongation. Arch Biochem Biophys. 1997 Aug 01; 344(1):200-7.
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Toxic heavy metal ions activate the heme-regulated eukaryotic initiation factor-2 alpha kinase by inhibiting the capacity of hemin-supplemented reticulocyte lysates to reduce disulfide bonds. J Biol Chem. 1991 Jul 05; 266(19):12695-702.
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Studies on in activation and reactivation of homogeneous rabbit liver phosphoprotein phosphatases by inorganic pyorphosphate and divalent cations. Biochim Biophys Acta. 1980; 613(1):95-105.