"Smoothened Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog signaling to ZINC FINGER PROTEIN GLI1. It may normally inhibit signaling in the absence of SONIC HEDGEHOG PROTEIN binding to PATCHED RECEPTOR-1.
| Descriptor ID |
D000072086
|
| MeSH Number(s) |
D12.776.543.750.695.017.500 D12.776.543.750.850.500.500
|
| Concept/Terms |
Smoothened Receptor- Smoothened Receptor
- Receptor, Smoothened
- Smoothened Protein
- Smoothened Receptors
- Receptors, Smoothened
|
Below are MeSH descriptors whose meaning is more general than "Smoothened Receptor".
Below are MeSH descriptors whose meaning is more specific than "Smoothened Receptor".
This graph shows the total number of publications written about "Smoothened Receptor" by people in this website by year, and whether "Smoothened Receptor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Smoothened Receptor" by people in Profiles.
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Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines. PLoS One. 2022; 17(12):e0266433.
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Switching the Smoothened Inhibitor May Have Benefit in Advanced Basal Cell Carcinoma. Am J Ther. 2018 May/Jun; 25(3):e394-e396.
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Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Oct; 19(10):1178-1188.
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Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma. Neuro Oncol. 2016 05; 18(5):649-55.
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Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin Cancer Res. 2013 Nov 15; 19(22):6305-12.
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9.
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The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction. 2009 Aug; 138(2):329-39.