"Floxuridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
| Descriptor ID |
D005467
|
| MeSH Number(s) |
D03.383.742.680.852.300.350 D13.570.230.430.432 D13.570.685.852.300.350
|
| Concept/Terms |
Floxuridine- Floxuridine
- 5-FUdR
- FUdR
- Fluorodeoxyuridine
- 5-Fluorodeoxyuridine
- 5 Fluorodeoxyuridine
|
Below are MeSH descriptors whose meaning is more general than "Floxuridine".
Below are MeSH descriptors whose meaning is more specific than "Floxuridine".
This graph shows the total number of publications written about "Floxuridine" by people in this website by year, and whether "Floxuridine" was a major or minor topic of these publications.
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Below are the most recent publications written about "Floxuridine" by people in Profiles.
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Regional heterogeneity and pharmacodynamics in human solid tumor histoculture. Cancer Chemother Pharmacol. 1999; 44(4):335-42.
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Absorption of 5'-deoxy-5-fluorouridine from colon. Pharm Res. 1989 Apr; 6(4):323-7.
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Biologic activity of 5'-deoxy-5-fluorouridine by rectal administration. Pharm Res. 1989 Apr; 6(4):318-22.
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Extraction of intracellular nucleosides and nucleotides with acetonitrile. Clin Chem. 1989 Jan; 35(1):48-51.
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Effect of uridine coadministration on 5'-deoxy-5-fluorouridine disposition in rats. Cancer Chemother Pharmacol. 1988; 22(1):5-10.
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Inhibition of intestinal pyrimidine nucleoside phosphorylases. Pharm Res. 1987 Oct; 4(5):425-8.
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Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats. J Pharm Sci. 1987 Sep; 76(9):699-702.
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Role of administration route in the therapeutic efficacy of doxifluridine. J Natl Cancer Inst. 1987 Mar; 78(3):527-32.
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Biological activities of 5-fluorouracil and its prodrug 5'-deoxy-5-fluorouridine in rats. Cancer Drug Deliv. 1987; 4(3):137-44.
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Pharmacokinetic studies of 5-fluorouracil and 5'-deoxy-5-fluorouridine in rats. J Pharmacol Exp Ther. 1983 Oct; 227(1):174-80.