Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins.
Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem. 2012 Jul 13; 287(29):24534-43.
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Cells, Cultured
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Cells, Cultured
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Cholesterol
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Cholesterol
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Electrophoresis, Polyacrylamide Gel
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Electrophoresis, Polyacrylamide Gel
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Fluorescence Resonance Energy Transfer
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Fluorescence Resonance Energy Transfer
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Hemolysis
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Hemolysis
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Humans
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Humans
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Microscopy, Electron
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Microscopy, Electron
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Perforin
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Perforin
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Point Mutation
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Point Mutation
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Protein Structure, Secondary
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Protein Structure, Tertiary