"X-linked Nuclear Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
| Descriptor ID |
D000075924
|
| MeSH Number(s) |
D08.811.399.340.375
|
| Concept/Terms |
X-linked Nuclear Protein- X-linked Nuclear Protein
- Nuclear Protein, X-linked
- X linked Nuclear Protein
- RAD54 Homolog Protein
- Homolog Protein, RAD54
- ATRX Protein
|
Below are MeSH descriptors whose meaning is more general than "X-linked Nuclear Protein".
Below are MeSH descriptors whose meaning is more specific than "X-linked Nuclear Protein".
This graph shows the total number of publications written about "X-linked Nuclear Protein" by people in this website by year, and whether "X-linked Nuclear Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "X-linked Nuclear Protein" by people in Profiles.
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Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. Oncotarget. 2014 Sep 30; 5(18):8083-92.
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Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012 Jul; 25(7):1033-9.
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Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011 Jul 22; 333(6041):425.
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011 Mar 04; 331(6021):1199-203.