3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
| Descriptor ID |
D001498
|
| MeSH Number(s) |
D03.383.725.203.600 D03.383.725.547.900
|
| Concept/Terms |
Bay-R-5417- Bay-R-5417
- Bay R 5417
- BayR5417
- Bay R5417
- R5417, Bay
Bay-K-8644- Bay-K-8644
- Bay K 8644
- BayK8644
- Bay-K8644
- Bay K8644
- BK-8644
- BK 8644
- BK8644
|
Below are MeSH descriptors whose meaning is more general than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
Below are MeSH descriptors whose meaning is more specific than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
This graph shows the total number of publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in this website by year, and whether "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in Profiles.
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Turtle Flexion Reflex Motor Patterns Show Windup, Mediated Partly by L-type Calcium Channels. Front Neural Circuits. 2017; 11:83.
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Serotonin reuptake inhibitor fluoxetine decreases arteriolar myogenic tone by reducing smooth muscle [Ca2+]i. J Cardiovasc Pharmacol. 2000 Jun; 35(6):849-54.
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Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C. Cardiovasc Res. 1999 Sep; 43(4):1018-28.
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Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca(2+) channel opener. Stroke. 1999 Sep; 30(9):1949-54.
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Ovariectomy and estrogen-induced alterations in myocardial contractility in female rabbits: role of the L-type calcium channel. J Pharmacol Exp Ther. 1998 Feb; 284(2):586-91.
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Effect of 17-beta estradiol in the rabbit: endothelium-dependent and -independent mechanisms of vascular relaxation. J Cardiovasc Pharmacol. 1997 Jul; 30(1):130-5.
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Early afterdepolarizations produced by d,l-sotalol and clofilium. J Cardiovasc Electrophysiol. 1997 Jun; 8(6):667-78.
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Patch-clamp evidence for calcium channels in apical membranes of rabbit kidney connecting tubules. J Clin Invest. 1993 Dec; 92(6):2731-6.