"Desipramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Descriptor ID |
D003891
|
MeSH Number(s) |
D03.633.300.240.281
|
Concept/Terms |
Desipramine- Desipramine
- Desmethylimipramine
- Demethylimipramine
|
Below are MeSH descriptors whose meaning is more general than "Desipramine".
Below are MeSH descriptors whose meaning is more specific than "Desipramine".
This graph shows the total number of publications written about "Desipramine" by people in this website by year, and whether "Desipramine" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Desipramine" by people in Profiles.
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Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes. Int J Mol Sci. 2020 May 28; 21(11).
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Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex. Int J Neuropsychopharmacol. 2011 Oct; 14(9):1219-32.
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Coadministration of nefazodone and desipramine: a pharmacokinetic interaction study. J Pak Med Assoc. 2007 May; 57(5):230-5.
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Plasma-soluble marker for intraorgan regional flows. Am J Physiol. 1983 Oct; 245(4):H707-12.