"Hemicholinium 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
| Descriptor ID |
D006426
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| MeSH Number(s) |
D02.092.877.435 D02.675.276.435
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemicholinium 3".
Below are MeSH descriptors whose meaning is more specific than "Hemicholinium 3".
This graph shows the total number of publications written about "Hemicholinium 3" by people in this website by year, and whether "Hemicholinium 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hemicholinium 3" by people in Profiles.
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Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain Res. 2007 Mar 02; 1135(1):12-21.
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Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. J Biol Chem. 2004 Jul 02; 279(27):28266-75.