Item Type | Name |
Concept
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Insulin-Like Growth Factor I
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Concept
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Transcription Factor AP-1
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Concept
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Insulin-Like Growth Factor Binding Proteins
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Concept
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Receptors, Tumor Necrosis Factor
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Concept
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Apoptosis Inducing Factor
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Concept
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NF-E2-Related Factor 2
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Concept
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Tumor Necrosis Factor-alpha
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Concept
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Connective Tissue Growth Factor
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Concept
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Transforming Growth Factor beta
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Concept
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Receptors, Vascular Endothelial Growth Factor
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Concept
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Vascular Endothelial Growth Factor Receptor-2
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Concept
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Vascular Endothelial Growth Factor A
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Concept
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Vascular Endothelial Growth Factor B
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Concept
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Transforming Growth Factor beta1
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Concept
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Thyroid Nuclear Factor 1
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Academic Article
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Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.
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Academic Article
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression.
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Academic Article
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Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response.
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Academic Article
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Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.
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Academic Article
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
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Academic Article
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.
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Academic Article
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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.
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Academic Article
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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
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Academic Article
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Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases.
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Academic Article
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Can simvastatin promote tumor growth by inducing angiogenesis similar to VEGF?
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Academic Article
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Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase.
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Academic Article
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Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
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Academic Article
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Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injury.
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Academic Article
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
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Academic Article
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Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy.
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Academic Article
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Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition.
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Academic Article
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Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.
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Academic Article
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Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.
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Academic Article
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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.
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Academic Article
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.
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Academic Article
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Connective tissue growth factor (CTGF) in age-related vascular pathologies.
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Academic Article
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Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging.
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Academic Article
|
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
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Academic Article
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Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
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Academic Article
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Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain.
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Academic Article
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The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.
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Academic Article
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Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.
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Academic Article
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Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.
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Academic Article
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
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Academic Article
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
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Academic Article
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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
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Academic Article
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IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.
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Academic Article
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Single Mild Traumatic Brain Injury Induces Persistent Disruption of the Blood-Brain Barrier, Neuroinflammation and Cognitive Decline in Hypertensive Rats.
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Academic Article
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Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.
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Academic Article
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Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease.
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Academic Article
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Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.
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Academic Article
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Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts.
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Academic Article
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Paucity of pericytes in germinal matrix vasculature of premature infants.
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Academic Article
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Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signaling.
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Academic Article
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Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus.
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Academic Article
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Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.
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Academic Article
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats.
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Academic Article
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.
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Academic Article
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Insulin-like growth factor-1 in CNS and cerebrovascular aging.
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Academic Article
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.
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Academic Article
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Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
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Academic Article
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.
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Academic Article
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Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.
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Academic Article
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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Academic Article
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Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype.
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Academic Article
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Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?
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Academic Article
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Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition.
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Academic Article
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Angiogenic inhibition reduces germinal matrix hemorrhage.
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Academic Article
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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.
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Academic Article
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Mitochondrial protection by resveratrol.
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Academic Article
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Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.
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Academic Article
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
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Academic Article
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.
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Academic Article
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.
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Academic Article
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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.
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Academic Article
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Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment.
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Academic Article
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Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
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Academic Article
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice.
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Grant
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Cerebral microhemorrhages and gait dysfunction in aging
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Grant
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Role of SIRT1 in vasoprotection
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Grant
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Cerebromicrovascular rejuvenation by heterochronic blood exchange
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Academic Article
|
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
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Academic Article
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Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging.
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