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Bourne, Christina
One or more keywords matched the following items that are connected to Bourne, Christina
Item TypeName
Concept Tetrahydrofolate Dehydrogenase
Academic Article Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Academic Article Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis.
Academic Article The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking.
Academic Article Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.
Academic Article Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.
Academic Article Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.
Academic Article Identification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductase.
Academic Article Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis.
Academic Article Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase.
Academic Article Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase.
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  • Oxidoreductases