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Lin, Jialing
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Lin, Jialing
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Concept
Dimerization
Academic Article
Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax.
Academic Article
After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
Academic Article
BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.
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Dimerization