After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-11896.

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subject areas

Amino Acid Sequence
Amino Acid Sequence
Apoptosis
Apoptosis
bcl-2-Associated X Protein
bcl-2-Associated X Protein
bcl-X Protein
bcl-X Protein
Binding Sites
Binding Sites
Dimerization
Dimerization
Mitochondria
Mitochondria
Models, Molecular
Models, Molecular
Molecular Sequence Data
Molecular Sequence Data
Permeability
Permeability
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-bcl-2

authors with profiles

Blaine H Mooers
Jialing Lin