bcl-2-Associated X Protein
"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
| Descriptor ID |
D051028
|
| MeSH Number(s) |
D12.644.360.075.718.400 D12.776.476.075.718.400
|
| Concept/Terms |
bcl-2-Associated X Protein- bcl-2-Associated X Protein
- Protein, bcl-2-Associated X
- X Protein, bcl-2-Associated
- bcl 2 Associated X Protein
- Bax Apoptosis Regulator Protein
- Bax Protein
- bcl2-Associated X Protein
- bcl2 Associated X Protein
|
Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".
This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in this website by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 1 | 3 |
| 2010 | 2 | 1 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles.
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Cysteine-based crosslinking approach for characterization of oligomeric pore-forming proteins in the mitochondrial membranes. Methods Enzymol. 2021; 649:371-396.
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Proapoptotic Mitochondrial Carrier Homolog Protein PSAP Mediates Death Receptor 6 Induced Apoptosis. J Alzheimers Dis. 2020; 74(4):1097-1106.
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CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFa/CHX-induced Apoptosis. Biomed Res Int. 2019; 2019:9071297.
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Tightening a deadly pore former. Nat Chem Biol. 2019 04; 15(4):316-317.
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Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1?cell line. Chem Biol Interact. 2019 Feb 25; 300:91-100.
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BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes. EMBO J. 2016 Jan 18; 35(2):208-36.
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After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-11896.
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p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice. Neoplasia. 2013 Aug; 15(8):966-74.
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Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. Cancer Prev Res (Phila). 2013 Jul; 6(7):731-43.
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(-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation. J Nutr Biochem. 2013 Jun; 24(6):940-7.