Nucleic Acid Heteroduplexes
"Nucleic Acid Heteroduplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.
| Descriptor ID |
D009692
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| MeSH Number(s) |
D13.444.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Heteroduplexes".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Heteroduplexes".
This graph shows the total number of publications written about "Nucleic Acid Heteroduplexes" by people in this website by year, and whether "Nucleic Acid Heteroduplexes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nucleic Acid Heteroduplexes" by people in Profiles.
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3' terminal nucleotides determine thermodynamic stabilities of mismatches at the ends of RNA helices. Biochemistry. 2008 Dec 16; 47(50):13418-27.
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Influence of minor groove substituents on the structure of DNA Holliday junctions. Biochemistry. 2004 Aug 03; 43(30):9813-22.
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Thermodynamic stability and structural features of the J4/5 loop in a Pneumocystis carinii group I intron. Biochemistry. 2003 Dec 09; 42(48):14184-96.
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Sheared Aanti.Aanti base pairs in a destabilizing 2 x 2 internal loop: the NMR structure of 5'(rGGCAAGCCU)2. Biochemistry. 2002 Dec 17; 41(50):14969-77.
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Nucleotides and heteroduplex DNA preserve the active conformation of Pseudomonas aeruginosa MutS by preventing protein oligomerization. Biochem J. 2002 Jan 01; 361(Pt 1):87-95.
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Factors affecting the thermodynamic stability of small asymmetric internal loops in RNA. Biochemistry. 2000 Aug 08; 39(31):9257-74.
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Use of duplex rigidity for stability and specificity in RNA tertiary structure. Biochemistry. 2000 May 23; 39(20):6183-9.
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Characterization of a local folding event of the Tetrahymena group I ribozyme: effects of oligonucleotide substrate length, pH, and temperature on the two substrate binding steps. Biochemistry. 1999 Oct 26; 38(43):14192-204.
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Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs. Biochemistry. 1998 Oct 20; 37(42):14719-35.