Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity.
Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J Exp Med. 2010 Aug 02; 207(8):1599-608.
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Animals
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Animals
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Brain
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Brain
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CD4-Positive T-Lymphocytes
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CD4-Positive T-Lymphocytes
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Cell Proliferation
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Cell Proliferation
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Encephalomyelitis, Autoimmune, Experimental
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Encephalomyelitis, Autoimmune, Experimental
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Female
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Female
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Gene Expression
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Gene Expression
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Glycoproteins
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Glycoproteins
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Homeodomain Proteins
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Homeodomain Proteins
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Humans
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Humans
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Interferon-gamma
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Interferon-gamma
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Interleukin-12
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Interleukin-12
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Interleukin-17
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Interleukin-17
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Leukocytes, Mononuclear
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Leukocytes, Mononuclear
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Lipopolysaccharides
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Lipopolysaccharides
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Lymphocyte Activation
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Lymphocyte Activation
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Macrophages, Peritoneal
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Macrophages, Peritoneal
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Male
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Male
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Mice
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Mice
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Knockout
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Myelin-Oligodendrocyte Glycoprotein
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Myelin-Oligodendrocyte Glycoprotein
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Myeloid Cells
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Myeloid Cells
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Nuclear Receptor Subfamily 1, Group F, Member 3
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Nuclear Receptor Subfamily 1, Group F, Member 3
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Peptide Fragments
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Peptide Fragments
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PPAR delta
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PPAR delta
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Spinal Cord
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Spinal Cord
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T-Box Domain Proteins
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T-Box Domain Proteins
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Th1 Cells
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Th1 Cells
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Thiazoles
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Thiazoles
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T-Lymphocytes, Helper-Inducer
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T-Lymphocytes, Helper-Inducer
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Tumor Necrosis Factor-alpha
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Tumor Necrosis Factor-alpha