"Frameshifting, Ribosomal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.
| Descriptor ID |
D018965
|
| MeSH Number(s) |
G02.111.660.871.200 G03.734.871.200 G05.308.215
|
| Concept/Terms |
Frameshifting, Ribosomal- Frameshifting, Ribosomal
- Ribosomal Frame Shift
- Frame Shift, Ribosomal
- Frame Shifts, Ribosomal
- Ribosomal Frame Shifts
- Frameshifting, Translational
- Translational Frameshifting
- Ribosomal Frameshifting
- Ribosomal Frameshift
- Frameshift, Ribosomal
- Frameshifts, Ribosomal
- Ribosomal Frameshifts
- Ribosomal Frame Shifting
- Frame Shifting, Ribosomal
|
Below are MeSH descriptors whose meaning is more general than "Frameshifting, Ribosomal".
Below are MeSH descriptors whose meaning is more specific than "Frameshifting, Ribosomal".
This graph shows the total number of publications written about "Frameshifting, Ribosomal" by people in this website by year, and whether "Frameshifting, Ribosomal" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "Frameshifting, Ribosomal" by people in Profiles.
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The case for the involvement of the Upf3p in programmed -1 ribosomal frameshifting. RNA. 2000 Dec; 6(12):1685-6.
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The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8721-6.
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Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents. Trends Biotechnol. 1998 Apr; 16(4):190-6.
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Peptidyl-transferase inhibitors have antiviral properties by altering programmed -1 ribosomal frameshifting efficiencies: development of model systems. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6606-11.