Genetic Heterogeneity

"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)

Descriptor ID	D018740
MeSH Number(s)	G05.365.331
Concept/Terms	Genetic Heterogeneity Genetic Heterogeneity Heterogeneity, Genetic Genetic Heterogeneities Heterogeneities, Genetic

Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Genetic Heterogeneity [G05.365.331]

Below are MeSH descriptors whose meaning is related to "Genetic Heterogeneity".

Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Heterogeneity" by people in this website by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publications.

Bar chart showing 22 publications over 15 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	1	1
1999	0	1	1
2000	0	1	1
2002	0	2	2
2003	0	1	1
2004	0	1	1
2007	0	1	1
2010	0	1	1
2011	0	2	2
2012	1	0	1
2013	0	1	1
2015	0	1	1
2016	1	2	3
2020	1	3	4

Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.

Jeong C, Wang K, Wilkin S, Taylor WTT, Miller BK, Bemmann JH, Stahl R, Chiovelli C, Knolle F, Ulziibayar S, Khatanbaatar D, Erdenebaatar D, Erdenebat U, Ochir A, Ankhsanaa G, Vanchigdash C, Ochir B, Munkhbayar C, Tumen D, Kovalev A, Kradin N, Bazarov BA, Miyagashev DA, Konovalov PB, Zhambaltarova E, Miller AV, Haak W, Schiffels S, Krause J, Boivin N, Erdene M, Hendy J, Warinner C. A Dynamic 6,000-Year Genetic History of Eurasia's Eastern Steppe. Cell. 2020 11 12; 183(4):890-904.e29.

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Edil BH, Luo W, Li M. Genomic and single cell sequencing facilitate the dissection of heterogeneity of pancreatic tumors. BMC Med. 2020 07 08; 18(1):177.

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Yan J, Yu S, Jia C, Li M, Chen J. Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges. Biochim Biophys Acta Rev Cancer. 2020 08; 1874(1):188367.

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Losic B, Craig AJ, Villacorta-Martin C, Martins-Filho SN, Akers N, Chen X, Ahsen ME, von Felden J, Labgaa I, D'Avola D, Allette K, Lira SA, Furtado GC, Garcia-Lezana T, Restrepo P, Stueck A, Ward SC, Fiel MI, Hiotis SP, Gunasekaran G, Sia D, Schadt EE, Sebra R, Schwartz M, Llovet JM, Thung S, Stolovitzky G, Villanueva A. Intratumoral heterogeneity and clonal evolution in liver cancer. Nat Commun. 2020 01 15; 11(1):291.

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Sharma A, Cao EY, Kumar V, Zhang X, Leong HS, Wong AML, Ramakrishnan N, Hakimullah M, Teo HMV, Chong FT, Chia S, Thangavelu MT, Kwang XL, Gupta R, Clark JR, Periyasamy G, Iyer NG, DasGupta R. Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy. Nat Commun. 2018 11 22; 9(1):4931.

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Zhou H, Neelakantan D, Ford HL. Clonal cooperativity in heterogenous cancers. Semin Cell Dev Biol. 2017 04; 64:79-89.

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Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D. Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016 07 25; 10 Suppl 2:18.

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Kim K, Bang SY, Ikari K, Yoo DH, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Kang YM, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Kim SK, Choe JY, Momohara S, Taniguchi A, Yamanaka H, Nath SK, Lee HS, Bae SC. Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis. Sci Rep. 2016 06 08; 6:27563.

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Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WC. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177.

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Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M, Looger LL, Nath SK. Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet. 2014 Mar 15; 23(6):1656-68.

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