"Antibody Diversity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
| Descriptor ID |
D000916
|
| MeSH Number(s) |
G05.365.036 G12.500.199
|
| Concept/Terms |
Antibody Diversity- Antibody Diversity
- Antibody Diversities
- Diversities, Antibody
- Diversity, Antibody
Germ Line Theory- Germ Line Theory
- Germ Line Theories
- Theories, Germ Line
- Theory, Germ Line
|
Below are MeSH descriptors whose meaning is more general than "Antibody Diversity".
Below are MeSH descriptors whose meaning is more specific than "Antibody Diversity".
This graph shows the total number of publications written about "Antibody Diversity" by people in this website by year, and whether "Antibody Diversity" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Antibody Diversity" by people in Profiles.
-
Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR. J Autoimmun. 2011 Sep; 37(2):104-12.
-
Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens. J Immunol. 2010 Jan 15; 184(2):1085-91.
-
Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol. 2008 Feb 15; 180(4):2019-23.