"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
| Descriptor ID |
D018740
|
| MeSH Number(s) |
G05.365.331
|
| Concept/Terms |
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
|
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in this website by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 2 | 3 |
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Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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A Dynamic 6,000-Year Genetic History of Eurasia's Eastern Steppe. Cell. 2020 11 12; 183(4):890-904.e29.
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Genomic and single cell sequencing facilitate the dissection of heterogeneity of pancreatic tumors. BMC Med. 2020 07 08; 18(1):177.
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Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges. Biochim Biophys Acta Rev Cancer. 2020 08; 1874(1):188367.
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Intratumoral heterogeneity and clonal evolution in liver cancer. Nat Commun. 2020 01 15; 11(1):291.
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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 09; 25(9):1415-1421.
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Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy. Nat Commun. 2018 11 22; 9(1):4931.
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Clonal cooperativity in heterogenous cancers. Semin Cell Dev Biol. 2017 04; 64:79-89.
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Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016 07 25; 10 Suppl 2:18.
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Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis. Sci Rep. 2016 06 08; 6:27563.
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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177.