Brain-Derived Neurotrophic Factor

"Brain-Derived Neurotrophic Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

Descriptor ID	D019208
MeSH Number(s)	D12.644.276.860.100 D12.776.467.860.100 D12.776.631.600.100 D23.529.850.100
Concept/Terms	Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor Brain Derived Neurotrophic Factor Factor, Brain-Derived Neurotrophic Neurotrophic Factor, Brain-Derived BDNF

Below are MeSH descriptors whose meaning is more general than "Brain-Derived Neurotrophic Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Nerve Growth Factors [D12.644.276.860]
Brain-Derived Neurotrophic Factor [D12.644.276.860.100]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Nerve Growth Factors [D12.776.467.860]
Brain-Derived Neurotrophic Factor [D12.776.467.860.100]
Nerve Tissue Proteins [D12.776.631]
Nerve Growth Factors [D12.776.631.600]
Brain-Derived Neurotrophic Factor [D12.776.631.600.100]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Nerve Growth Factors [D23.529.850]
Brain-Derived Neurotrophic Factor [D23.529.850.100]

Below are MeSH descriptors whose meaning is related to "Brain-Derived Neurotrophic Factor".

Below are MeSH descriptors whose meaning is more specific than "Brain-Derived Neurotrophic Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Brain-Derived Neurotrophic Factor" by people in this website by year, and whether "Brain-Derived Neurotrophic Factor" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2014 and 2015 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2006	1	0	1
2010	0	1	1
2011	0	1	1
2012	1	0	1
2014	1	1	2
2015	1	1	2
2018	1	0	1
2019	2	0	2

Below are the most recent publications written about "Brain-Derived Neurotrophic Factor" by people in Profiles.

Yang X, Brobst D, Chan WS, Tse MCL, Herlea-Pana O, Ahuja P, Bi X, Zaw AM, Kwong ZSW, Jia WH, Zhang ZG, Zhang N, Chow SKH, Cheung WH, Louie JCY, Griffin TM, Nong W, Hui JHL, Du GH, Noh HL, Saengnipanthkul S, Chow BKC, Kim JK, Lee CW, Chan CB. Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility. Sci Signal. 2019 08 13; 12(594).

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Lee YI, Kim YG, Pyeon HJ, Ahn JC, Logan S, Orock A, Joo KM, Lorincz A, Deák F. Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain. Geroscience. 2019 04; 41(2):109-123.

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Wood J, Tse MCL, Yang X, Brobst D, Liu Z, Pang BPS, Chan WS, Zaw AM, Chow BKC, Ye K, Lee CW, Chan CB. BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle. Metabolism. 2018 10; 87:113-122.

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Walsh JJ, Scribbans TD, Bentley RF, Kellawan JM, Gurd B, Tschakovsky ME. Neurotrophic growth factor responses to lower body resistance training in older adults. Appl Physiol Nutr Metab. 2016 Mar; 41(3):315-23.

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Rao G, Xie J, Hedrick A, Awasthi V. Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model. Neuropharmacology. 2015 Dec; 99:318-27.

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Hartnett ME, Morrison MA, Smith S, Yanovitch TL, Young TL, Colaizy T, Momany A, Dagle J, Carlo WA, Clark EA, Page G, Murray J, DeAngelis MM, Cotten CM. Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. Invest Ophthalmol Vis Sci. 2014 Aug 12; 55(10):6194-203.

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Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology. 2015 Jan; 40(2):463-71.

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Gyekis JP, Yu W, Dong S, Wang H, Qian J, Kota P, Yang J. No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis. . 2013 Jan; 162B(1):61-70.

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Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med. 2011 Dec 18; 18(1):153-8.

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Kong L, Zhou X, Li F, Yodoi J, McGinnis J, Cao W. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiol Dis. 2010 Jun; 38(3):446-55.

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