Amyloid beta-Protein Precursor

"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Descriptor ID	D016564
MeSH Number(s)	D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
Concept/Terms	Amyloid beta-Protein Precursor Amyloid beta-Protein Precursor Amyloid beta Protein Precursor beta-Protein Precursor, Amyloid Amyloid beta Precursor Protein Protease Nexin II Nexin II, Protease beta-Amyloid Protein Precursor beta Amyloid Protein Precursor Protease Nexin 2 Nexin 2, Protease Amyloid A4 Protein Precursor Amyloid Protein Precursor

Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Amyloid beta-Protein Precursor [D12.776.049.407.249]
Membrane Proteins [D12.776.543]
Amyloid beta-Protein Precursor [D12.776.543.039]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Protease Nexins [D12.776.645.468]
Amyloid beta-Protein Precursor [D12.776.645.468.500]
Protein Precursors [D12.776.811]
Amyloid beta-Protein Precursor [D12.776.811.050]

Below are MeSH descriptors whose meaning is related to "Amyloid beta-Protein Precursor".

Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".

Amyloid beta-Protein Precursor
Amyloid beta-Peptides

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	0	1
2006	2	0	2
2007	0	1	1
2008	0	1	1
2009	1	0	1
2011	1	0	1
2013	2	1	3
2014	0	1	1
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.

Nyul-Toth A, DelFavero J, Mukli P, Tarantini A, Ungvari A, Yabluchanskiy A, Csiszar A, Ungvari Z, Tarantini S. Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease. Geroscience. 2021 08; 43(4):1947-1957.

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Van Skike CE, Hussong SA, Hernandez SF, Banh AQ, DeRosa N, Galvan V. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. J Neurosci. 2021 05 12; 41(19):4305-4320.

View in: PubMed
Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-ß plaque pathology in an APP knock-in mouse model. Mol Neurodegener. 2020 01 08; 15(1):3.

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Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J. Secreted amyloid-ß precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. Science. 2019 01 11; 363(6423).

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Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36.

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Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617.

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Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8.

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Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1120-30.

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Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab. 2013 Sep; 33(9):1412-21.

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Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77.

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