Amyloid beta-Protein Precursor

"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Descriptor ID	D016564
MeSH Number(s)	D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
Concept/Terms	Amyloid beta-Protein Precursor Amyloid beta-Protein Precursor Amyloid beta Protein Precursor beta-Protein Precursor, Amyloid Amyloid beta Precursor Protein Protease Nexin II Nexin II, Protease beta-Amyloid Protein Precursor beta Amyloid Protein Precursor Protease Nexin 2 Nexin 2, Protease Amyloid A4 Protein Precursor Amyloid Protein Precursor

Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Amyloid beta-Protein Precursor [D12.776.049.407.249]
Membrane Proteins [D12.776.543]
Amyloid beta-Protein Precursor [D12.776.543.039]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Protease Nexins [D12.776.645.468]
Amyloid beta-Protein Precursor [D12.776.645.468.500]
Protein Precursors [D12.776.811]
Amyloid beta-Protein Precursor [D12.776.811.050]

Below are MeSH descriptors whose meaning is related to "Amyloid beta-Protein Precursor".

Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".

Amyloid beta-Protein Precursor
Amyloid beta-Peptides

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 3 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	0	1
2006	2	0	2
2007	0	1	1
2008	0	1	1
2009	1	0	1
2011	1	0	1
2013	2	1	3
2014	0	1	1
2017	0	1	1
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.

Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-ß plaque pathology in an APP knock-in mouse model. Mol Neurodegener. 2020 01 08; 15(1):3.

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Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J. Secreted amyloid-ß precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. Science. 2019 01 11; 363(6423).

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Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9.

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Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36.

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Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease. . 2013 Oct 15; 305(8):H1120-30.

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Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77.

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Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochim Biophys Acta. 2013 Jun; 1833(6):1562-71.

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Prodan CI, Ross ED, Stoner JA, Cowan LD, Vincent AS, Dale GL. Coated-platelet levels and progression from mild cognitive impairment to Alzheimer disease. Neurology. 2011 Jan 18; 76(3):247-52.

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Tuli A, Sharma M, Wang X, Simone LC, Capek HL, Cate S, Hildebrand WH, Naslavsky N, Caplan S, Solheim JC. Amyloid precursor-like protein 2 association with HLA class I molecules. Cancer Immunol Immunother. 2009 Sep; 58(9):1419-31.

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Prodan CI, Ross ED, Vincent AS, Dale GL. Rate of progression in Alzheimer's disease correlates with coated-platelet levels--a longitudinal study. Transl Res. 2008 Sep; 152(3):99-102.

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