"Neurofibromin 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane protein homologous to the ERM (Ezrin-Radixin-Moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. Alterations in neurofibromin 2 are the cause of NEUROFIBROMATOSIS 2.
| Descriptor ID |
D025581
|
| MeSH Number(s) |
D12.776.543.685 D12.776.624.776.612
|
| Concept/Terms |
Neurofibromin 2- Neurofibromin 2
- Moesin-Ezrin-Radixin-Like Protein
- Moesin Ezrin Radixin Like Protein
- Schwannomin Protein
- Protein, Schwannomin
- Neurofibromatosis Type 2 Protein
- NF2 Gene Product
- Gene Product, NF2
- Schwannomin
- Merlin
- Neurofibromatosis 2 Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Neurofibromin 2".
Below are MeSH descriptors whose meaning is more specific than "Neurofibromin 2".
This graph shows the total number of publications written about "Neurofibromin 2" by people in this website by year, and whether "Neurofibromin 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neurofibromin 2" by people in Profiles.
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Phase II Study of Defactinib (VS6063) in Patients With Tumors With NF2 Loss: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol U. JCO Precis Oncol. 2024 Dec; 8:e2400327.
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Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling. Cell Commun Signal. 2017 09 18; 15(1):34.
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9.