"Dystrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
| Descriptor ID |
D016189
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| MeSH Number(s) |
D12.776.210.500.250 D12.776.220.250 D12.776.543.250
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dystrophin".
Below are MeSH descriptors whose meaning is more specific than "Dystrophin".
This graph shows the total number of publications written about "Dystrophin" by people in this website by year, and whether "Dystrophin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dystrophin" by people in Profiles.
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Executive Skills and Academic Achievement in the Dystrophinopathies. J Int Neuropsychol Soc. 2018 10; 24(9):928-938.
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Mutation in dystrophin-encoding gene affects energy metabolism in mouse myoblasts. Biochem Biophys Res Commun. 2009 Aug 28; 386(3):463-6.
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Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins. Mol Biol Cell. 2003 Nov; 14(11):4499-511.