"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
| Descriptor ID |
D016160
|
| MeSH Number(s) |
D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
|
| Concept/Terms |
p105-Rb Protein- p105-Rb Protein
- p105 Rb Protein
- Retinoblastoma Nuclear Phosphoprotein p105-Rb
- Retinoblastoma Nuclear Phosphoprotein p105 Rb
|
Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".
This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2000 | 3 | 0 | 3 |
| 2001 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.
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The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness. Clin Cancer Res. 2014 Nov 01; 20(21):5468-5482.
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A novel translocation t(11;13) (q21;q14.2) in a child with suprasellar primitive neuroectodermal tumor and retinoblastoma. Ophthalmic Genet. 2013 Mar-Jun; 34(1-2):97-100.
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Expression and role of p53 in the retina. Invest Ophthalmol Vis Sci. 2012 Mar 15; 53(3):1362-71.
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miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011 Mar 25; 406(4):518-23.
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Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11501-6.
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A novel subtelomeric translocation t(5;9) and a deletion of the RB1 gene in a patient with acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet. 2008 Feb; 181(1):36-9.
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The role of acetylation in rDNA transcription. Nucleic Acids Res. 2001 Oct 15; 29(20):4114-24.
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Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol Cell. 2000 Nov; 6(5):1059-66.
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Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. 2000 Oct 12; 19(43):4988-99.
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RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest. Oncogene. 2000 Jul 20; 19(31):3487-97.