"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
| Descriptor ID |
D016203
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
|
| Concept/Terms |
CDC2 Protein Kinase- CDC2 Protein Kinase
- Protein Kinase, CDC2
- Cdk1 Protein Kinase
- Protein Kinase, Cdk1
- cdk1 Kinase
- cdc2+ Protein
- Cyclin-Dependent Kinase 1
- Cyclin Dependent Kinase 1
p34cdc2 Protein- p34cdc2 Protein
- Protein p34cdc2
- p34cdc2, Protein
- Histone Kinase p34(cdc2)
|
Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".
This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.
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Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science. 2023 04 21; 380(6642):eabn7625.
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The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res. 2021 10 11; 49(18):10507-10523.
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CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019 04 01; 218(4):1164-1181.
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Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res. 2018 12 15; 24(24):6459-6470.
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Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol. 2013 Jan; 15(1):40-9.
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Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell. 2011 Apr 15; 22(8):1191-206.
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Podophyllum hexandrum fraction (REC-2006) shows higher radioprotective efficacy in the p53-carrying hepatoma cell line: a role of cell cycle regulatory proteins. Integr Cancer Ther. 2009 Sep; 8(3):261-72.
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Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit. Mol Biol Cell. 2009 Mar; 20(6):1737-48.
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Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1025-32.
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Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. Int J Radiat Oncol Biol Phys. 2006 Nov 01; 66(3):852-9.