"Focal Adhesion Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
| Descriptor ID |
D051417
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.500 D12.776.744.493
|
| Concept/Terms |
Focal Adhesion Kinase 1- Focal Adhesion Kinase 1
- Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
- Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
- p125FAK Protein
- Protein Tyrosine Kinase 2
- Endogenous Substrate pp120
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 1".
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This graph shows the total number of publications written about "Focal Adhesion Kinase 1" by people in this website by year, and whether "Focal Adhesion Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Focal Adhesion Kinase 1" by people in Profiles.
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Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- ?C- terminal fragments. PLoS One. 2020; 15(4):e0231739.
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Focal Adhesion Kinase in Ovarian Cancer: A Potential Therapeutic Target for Platinum and Taxane-Resistant Tumors. Curr Cancer Drug Targets. 2019; 19(3):179-188.
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Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells. Mol Ther. 2004 Apr; 9(4):510-8.
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Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin. FEBS Lett. 1999 Jul 09; 454(3):252-6.
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Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery. 1996 Aug; 120(2):427-31; discussion 432.