MDS1 and EVI1 Complex Locus Protein
"MDS1 and EVI1 Complex Locus Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA binding protein, transcriptional regulator, and proto-oncogene protein that contains 10 CYS2-HIS2 ZINC FINGERS. It functions as a positive or negative regulator of expression for target genes involved in organism development.
| Descriptor ID |
D000074008
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| MeSH Number(s) |
D12.776.260.534 D12.776.624.664.700.129 D12.776.930.419
|
| Concept/Terms |
MDS1 and EVI1 Complex Locus Protein- MDS1 and EVI1 Complex Locus Protein
- Ecotropic Virus Integration Site 1 Protein Homolog
- Zinc Finger Protein Evi1
- MECOM Protein
- Myelodysplasia Syndrome-Associated Protein 1
- Myelodysplasia Syndrome Associated Protein 1
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Below are MeSH descriptors whose meaning is more general than "MDS1 and EVI1 Complex Locus Protein".
Below are MeSH descriptors whose meaning is more specific than "MDS1 and EVI1 Complex Locus Protein".
This graph shows the total number of publications written about "MDS1 and EVI1 Complex Locus Protein" by people in this website by year, and whether "MDS1 and EVI1 Complex Locus Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "MDS1 and EVI1 Complex Locus Protein" by people in Profiles.
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Physical and functional interaction of the proto-oncogene EVI1 and tumor suppressor gene HIC1 deregulates Bcl-xL mediated block in apoptosis. Int J Biochem Cell Biol. 2014 Aug; 53:320-8.
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EVI1 targets platelet endothelial cell adhesion molecule and up-regulates its expression in chronic myeloid leukemia. Leuk Lymphoma. 2014 Apr; 55(4):954-6.
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SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic trioxide. Biochim Biophys Acta. 2013 Oct; 1833(10):2357-68.
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EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1. Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):269-75.