p300-CBP Transcription Factors
"p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
| Descriptor ID |
D050880
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.575 D12.776.930.680
|
| Concept/Terms |
p300-CBP Transcription Factors- p300-CBP Transcription Factors
- Transcription Factors, p300-CBP
- p300 CBP Transcription Factors
- p300-CBP Coactivator
- Coactivator, p300-CBP
- p300 CBP Coactivator
- p300-CBP Protein
- p300 CBP Protein
|
Below are MeSH descriptors whose meaning is more general than "p300-CBP Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "p300-CBP Transcription Factors".
This graph shows the total number of publications written about "p300-CBP Transcription Factors" by people in this website by year, and whether "p300-CBP Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "p300-CBP Transcription Factors" by people in Profiles.
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Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E145-E151.
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Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. 2017 12; 6(12):1574-1584.
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A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012 Dec; 26(12):5106-14.
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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13787-92.
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Acetylation of the proto-oncogene EVI1 abrogates Bcl-xL promoter binding and induces apoptosis. PLoS One. 2011; 6(9):e25370.
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Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 01; 285(40):30443-52.
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Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009 May 28; 113(22):5568-74.
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Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007 Aug 01; 101(5):1252-65.
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Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 2004 Apr 09; 279(15):14909-16.
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Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res. 2004 Jan 15; 64(2):456-62.