Interferon Regulatory Factors
"Interferon Regulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
| Descriptor ID |
D050835
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| MeSH Number(s) |
D12.644.360.024.302 D12.776.157.057.050 D12.776.260.504 D12.776.476.024.385 D12.776.930.332
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factors".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factors".
This graph shows the total number of publications written about "Interferon Regulatory Factors" by people in this website by year, and whether "Interferon Regulatory Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 3 | 0 | 3 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interferon Regulatory Factors" by people in Profiles.
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Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms. Am J Hum Genet. 2021 09 02; 108(9):1631-1646.
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Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Front Immunol. 2020; 11:577718.
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Non-random distribution of deleterious mutations in the DNA and protein-binding domains of IRF6 are associated with Van Der Woude syndrome. Mol Genet Genomic Med. 2020 08; 8(8):e1355.
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Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease. Kidney360. 2020 Mar; 1(3):179-190.
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Weight Loss Results in Increased Expression of Anti-Inflammatory Protein CRISPLD2 in Mouse Adipose Tissue. Obesity (Silver Spring). 2019 12; 27(12):2025-2036.
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IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 07; 12(4):1025-1037.
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Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Res. 2018 11; 28(11):1621-1635.
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Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat Immunol. 2017 06; 18(6):683-693.
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Genetics in Sjögren Syndrome. Rheum Dis Clin North Am. 2016 08; 42(3):435-47.
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Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol. 2016 Apr; 68(4):932-43.