"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
| Descriptor ID |
D051380
|
| MeSH Number(s) |
D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377
|
| Concept/Terms |
GRB2 Adaptor Protein- GRB2 Adaptor Protein
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
|
Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".
This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.
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Conformation-Dependent Human p52Shc Phosphorylation by Human c-Src. Biochemistry. 2015 Jun 09; 54(22):3469-82.
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Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem. 2009 Dec 25; 284(52):36202-36212.
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Convergence of signaling pathways on the activation of ERK in B cells. J Biol Chem. 2002 Jun 28; 277(26):23420-6.
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The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells. J Biol Chem. 2000 Jul 07; 275(27):20480-7.
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Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J Biol Chem. 1999 Jun 25; 274(26):18769-76.
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Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells. Mol Immunol. 1998 Dec; 35(17):1135-46.
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Inhibitory signaling by B cell Fc gamma RIIb. Curr Opin Immunol. 1998 Jun; 10(3):306-12.
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Activation-induced bi-dentate interaction of SHIP and Shc in B lymphocytes. J Cell Biochem. 1997 Oct 01; 67(1):32-42.
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Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997 Jun 06; 272(23):14562-70.
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Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions. J Immunol. 1997 Feb 01; 158(3):1125-32.