Protein Isoforms

"Protein Isoforms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

Descriptor ID	D020033
MeSH Number(s)	D12.776.800
Concept/Terms	Protein Isoforms Protein Isoforms Isoforms, Protein Isoforms Splice Variants, Protein Splice Variants, Protein Variants, Protein Splice Protein Splice Variants

Below are MeSH descriptors whose meaning is more general than "Protein Isoforms".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Protein Isoforms [D12.776.800]

Below are MeSH descriptors whose meaning is related to "Protein Isoforms".

Below are MeSH descriptors whose meaning is more specific than "Protein Isoforms".

Protein Isoforms
Isoenzymes

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Isoforms" by people in this website by year, and whether "Protein Isoforms" was a major or minor topic of these publications.

Bar chart showing 90 publications over 24 distinct years, with a maximum of 8 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
1999	0	1	1
2000	0	2	2
2001	0	4	4
2002	1	6	7
2003	0	6	6
2004	1	3	4
2005	0	3	3
2006	0	1	1
2007	0	4	4
2008	0	7	7
2009	1	4	5
2010	0	8	8
2011	0	3	3
2012	1	3	4
2013	0	2	2
2014	0	5	5
2015	0	4	4
2016	1	1	2
2017	1	2	3
2018	0	5	5
2019	0	5	5
2020	0	2	2
2021	0	1	1

Below are the most recent publications written about "Protein Isoforms" by people in Profiles.

Rodden LN, Gilliam KM, Lam C, Rojsajjakul T, Mesaros C, Dionisi C, Pook M, Pandolfo M, Lynch DR, Blair IA, Bidichandani SI. DNA methylation in Friedreich ataxia silences expression of frataxin isoform E. Sci Rep. 2022 03 23; 12(1):5031.

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Melani RD, Gerbasi VR, Anderson LC, Sikora JW, Toby TK, Hutton JE, Butcher DS, Negrão F, Seckler HS, Srzentic K, Fornelli L, Camarillo JM, LeDuc RD, Cesnik AJ, Lundberg E, Greer JB, Fellers RT, Robey MT, DeHart CJ, Forte E, Hendrickson CL, Abbatiello SE, Thomas PM, Kokaji AI, Levitsky J, Kelleher NL. The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells. Science. 2022 01 28; 375(6579):411-418.

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Bishop CE, Shadid TM, Lavey NP, Kempher ML, Ballard JD, Duerfeldt AS. Identification of ClpP Dual Isoform Disruption as an Antisporulation Strategy for Clostridioides difficile. J Bacteriol. 2022 02 15; 204(2):e0041121.

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Drumond-Bock AL, Bieniasz M. The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis. Mol Cancer. 2021 11 10; 20(1):145.

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Burnham AJ, Miller JR, Singh I, Billings EA, Rush MA, Air GM, Bour S. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 10 15; 304:198545.

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Mishra SJ, Khandelwal A, Banerjee M, Balch M, Peng S, Davis RE, Merfeld T, Munthali V, Deng J, Matts RL, Blagg BSJ. Selective Inhibition of the Hsp90a Isoform. Angew Chem Int Ed Engl. 2021 05 03; 60(19):10547-10551.

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Chandrakesan P, Panneerselvam J, May R, Weygant N, Qu D, Berry WR, Pitts K, Stanger BZ, Rao CV, Bronze MS, Houchen CW. DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization. Mol Cancer Ther. 2020 07; 19(7):1539-1549.

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Doubleday PF, Fornelli L, Kelleher NL. Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. J Proteome Res. 2020 02 07; 19(2):938-948.

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Huguet R, Mullen C, Srzentic K, Greer JB, Fellers RT, Zabrouskov V, Syka JEP, Kelleher NL, Fornelli L. Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms. Anal Chem. 2019 12 17; 91(24):15732-15739.

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Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC. Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7.

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