"Protein C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
| Descriptor ID |
D011486
|
| MeSH Number(s) |
D08.622.705 D12.776.124.650 D12.776.395.635 D23.113.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein C".
Below are MeSH descriptors whose meaning is more specific than "Protein C".
This graph shows the total number of publications written about "Protein C" by people in this website by year, and whether "Protein C" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 2 | 1 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein C" by people in Profiles.
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Should direct oral anticoagulants be used to treat protein C or S deficiency? JAAPA. 2023 Jul 01; 36(7):8-10.
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Prospective evaluation of protein C and factor VIII in prediction of cancer-associated thrombosis. Thromb Res. 2015 Dec; 136(6):1120-5.
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A multicenter evaluation of the safety of drotrecogin alfa (activated) in patients with baseline bleeding precautions. Curr Drug Saf. 2012 Feb; 7(1):3-7.
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Blood coagulation: hemostasis and thrombin regulation. Anesth Analg. 2009 May; 108(5):1433-46.
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Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med. 2009 Jan; 37(1):19-25.
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Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood. 2007 Feb 01; 109(3):1003-9.
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Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement. J Thromb Haemost. 2005 May; 3(5):962-8.
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Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care. 2004 Apr; 8(2):R82-90.
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Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor. Arch Pathol Lab Med. 2002 Nov; 126(11):1337-48.
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Immobilization of human thrombomodulin to expanded polytetrafluoroethylene. J Surg Res. 2002 Jun 15; 105(2):200-8.