Protein Synthesis Inhibitors
"Protein Synthesis Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
| Descriptor ID |
D011500
|
| MeSH Number(s) |
D27.505.519.389.760
|
| Concept/Terms |
Protein Synthesis Inhibitors- Protein Synthesis Inhibitors
- Inhibitors, Protein Synthesis
- Protein Synthesis Antagonists
- Antagonists, Protein Synthesis
|
Below are MeSH descriptors whose meaning is more general than "Protein Synthesis Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Protein Synthesis Inhibitors".
This graph shows the total number of publications written about "Protein Synthesis Inhibitors" by people in this website by year, and whether "Protein Synthesis Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
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Below are the most recent publications written about "Protein Synthesis Inhibitors" by people in Profiles.
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Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol. 2008 Jun 06; 379(3):505-19.
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Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I. Gene Expr. 2008; 14(3):131-47.
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Part X. Tetracycline and glycylcycline antimicrobials. J Okla State Med Assoc. 2007 Jun; 100(6):241-7.
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Chromosome condensation in the absence of the non-SMC subunits of MukBEF. J Bacteriol. 2006 Jun; 188(12):4431-41.
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Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem. 2003 Jun 06; 278(23):20593-602.
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Rrn3 becomes inactivated in the process of ribosomal DNA transcription. J Biol Chem. 2003 May 23; 278(21):18953-9.
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Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. J Biol Chem. 2002 Jul 26; 277(30):27423-32.
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Reorganization of the actin cytoskeleton in the protruding lamellae of human fibroblasts. Cell Motil Cytoskeleton. 2001 Sep; 50(1):13-32.
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Separation of integrin-dependent adhesion from morphological changes based on differential PLC specificities. J Leukoc Biol. 1999 Jan; 65(1):127-36.
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Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate. Eur J Biochem. 1998 Aug 01; 255(3):552-62.