"GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
|GRB2 Adaptor Protein
- GRB2 Adaptor Protein
- Abundant Src Homology Protein
- Growth Factor Receptor-Bound Protein-2
- Growth Factor Receptor Bound Protein 2
Below are MeSH descriptors whose meaning is more general than "GRB2 Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "GRB2 Adaptor Protein".
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Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles.
Conformation-Dependent Human p52Shc Phosphorylation by Human c-Src. Biochemistry. 2015 Jun 09; 54(22):3469-82.
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem. 2009 Dec 25; 284(52):36202-36212.
Convergence of signaling pathways on the activation of ERK in B cells. J Biol Chem. 2002 Jun 28; 277(26):23420-6.
The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells. J Biol Chem. 2000 Jul 07; 275(27):20480-7.
Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J Biol Chem. 1999 Jun 25; 274(26):18769-76.
Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells. Mol Immunol. 1998 Dec; 35(17):1135-46.
Inhibitory signaling by B cell Fc gamma RIIb. Curr Opin Immunol. 1998 Jun; 10(3):306-12.
Activation-induced bi-dentate interaction of SHIP and Shc in B lymphocytes. J Cell Biochem. 1997 Oct 01; 67(1):32-42.
Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997 Jun 06; 272(23):14562-70.
Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions. J Immunol. 1997 Feb 01; 158(3):1125-32.