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Courtney Wayne Houchen

TitleProf,Regents
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Gastroenterology
AddressAAT 7400
800 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01DK119495     (HOUCHEN, COURTNEY WAYNE)Aug 20, 2019 - May 31, 2024
    NIH
    Mechanisms of tuft cell mediated regulation of the intestinal stem cell niche following injury
    Role: Principal Investigator
    I01CX001686     (HOUCHEN, COURTNEY WAYNE)Oct 1, 2018 - Sep 30, 2022
    NIH
    Circulating Biomarkers for the Detection of Human Liver Diseases
    Role: Principal Investigator
    I01BX004131     (HOUCHEN, COURTNEY WAYNE)Oct 1, 2017 - Sep 30, 2026
    NIH
    Molecular targeting of DCLK1 signaling in hepatocellular carcinoma
    Role: Principal Investigator
    R25MD011564     (STAVRAKIS, STAVROS)Sep 24, 2017 - May 31, 2022
    NIH
    Addressing Health Disparities among Oklahoma Minority and Rural Communities through Clinical Research Education and Career Development
    Role: Co-Principal Investigator
    R01CA214017     (HOUCHEN, COURTNEY WAYNE)Jun 15, 2017 - May 31, 2022
    NIH
    The role of Dclk1 in the initiation of colorectal cancer
    Role: Principal Investigator
    R01CA182869     (HOUCHEN, COURTNEY WAYNE)Apr 1, 2015 - Mar 31, 2021
    NIH
    The role of DCLK1 in the initiation of pancreatic ductal adenocarcinoma
    Role: Principal Investigator
    R21CA186175     (HOUCHEN, COURTNEY WAYNE)Dec 1, 2014 - Aug 31, 2017
    NIH
    Targeting DCLK1 kinase activity in pancreatic cancer
    Role: Principal Investigator
    I01BX001952     (HOUCHEN, COURTNEY WAYNE)Oct 1, 2013 - Sep 30, 2017
    NIH
    The Gastrointestinal Stem Cell Response to Injury
    Role: Principal Investigator
    I01BX002188     (HOUCHEN, COURTNEY WAYNE)Apr 1, 2013 - Mar 31, 2023
    NIH
    Central Mechanisms Modulating Visceral Sensitivity
    Role: Principal Investigator
    R21CA137482     (HOUCHEN, COURTNEY WAYNE)Apr 1, 2010 - Mar 31, 2012
    NIH
    Pancreatic Stem Cells and Cancer
    Role: Principal Investigator
    U01DK085508     (HOUCHEN, COURTNEY WAYNE)Sep 30, 2009 - Aug 31, 2015
    NIH
    Isolation and Characterization of Intestinal Stem Cells Using Novel Markers (RP)
    Role: Principal Investigator
    R03DK065887     (HOUCHEN, COURTNEY WAYNE)Feb 1, 2004 - Nov 30, 2008
    NIH
    PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Role: Principal Investigator
    K08DK002822     (HOUCHEN, COURTNEY WAYNE)Sep 15, 2000 - Jun 30, 2006
    NIH
    PROSTAGLANDIN E2 RECEPTORS IN GASTROINTESTINAL INJURY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou Z, Cai Y, Yuan H, Chen Q, Zhao SW, Yang J, Liu M, Arreola AX, Ren Y, Xu C, McNally LR, Bronze MS, Houchen CW, Jiang K, Chen WR, Zhang Y, Li M. Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy. Cancer Res Commun. 2025 Aug 01; 5(8):1288-1297. PMID: 40693608; PMCID: PMC12326525.
      Citations:    Fields:    Translation:Humans
    2. Dogra S, Elayapillai SP, Qu D, Pitts K, Filatenkov A, Houchen CW, Berry WL, Moxley K, Hannafon BN. Corrigendum to "Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer" [Cancer Lett. 2023 Dec 1;578:216437]. Cancer Lett. 2025 Oct 10; 630:217889. PMID: 40610305.
      Citations:    Fields:    
    3. Moore LL, Jaboin J, Brown ML, Houchen CW. Balancing Regeneration and Resistance: Targeting DCLK1 to Mitigate Gastrointestinal Radiation Injury and Oncogenesis. Cancers (Basel). 2025 Jun 19; 17(12). PMID: 40563698; PMCID: PMC12190577.
      Citations:    
    4. Yuan H, Chen Q, Jiang K, Houchen CW, Zhang Y, Li M. Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy. Clin Cancer Res. 2025 May 15; 31(10):1821-1823. PMID: 40036010.
      Citations:    Fields:    Translation:Humans
    5. Mohammed S, Jiang C, Pennington T, Bhaskaran S, Ohene-Marfo P, Georgescu C, Pitts K, Tran A, Peng Z, Singh A, Yang Z, Li T, Hannafon B, Houchen C, Wren JD, Galvan V, Ahsan N, Kinter M, Lewis TL, Deepa SS. A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver. bioRxiv. 2025 May 03. PMID: 40654837; PMCID: PMC12247894.
      Citations:    
    6. Zhang L, Yang J, Zhou Z, Ren Y, Chen B, Tang A, Zhang K, Li C, Zhou H, Fung KM, Xu C, Kang C, Battiste JD, Bronze MS, Houchen CW, Liu Z, Dunn IF, Cavenee WK, Li M. A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity. Proc Natl Acad Sci U S A. 2025 May 06; 122(18):e2427073122. PMID: 40305049; PMCID: PMC12067291.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Retraction Note: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2025 Apr 19; 24(1):120. PMID: 40253332; PMCID: PMC12008944.
      Citations:    Fields:    
    8. Moore LL, Houchen CW. Evolving insights into pancreatic tumor initiation and progression through DCLK1-expressing tuft cells. Dev Cell. 2025 Mar 24; 60(6):817-818. PMID: 40132546.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Moore LL, Qu D, Chandrekesan P, Pitts K, May R, Anderson BE, Brown M, Houchen CW. A Novel D-peptide modulates DCLK1 Gelsolin interactions, reducing PDAC tumor growth. Res Sq. 2025 Mar 11. PMID: 40162222; PMCID: PMC11952641.
      Citations:    
    10. Houchen CW, Li M. Glutaminase 2-Mediated Yes Associated Protein 1 Glutamylation Facilitates Immune Evasion in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2025 Mar 06. PMID: 40057131.
      Citations:    Fields:    
    11. Panneerselvam J, Madka V, Rai R, Morris KT, Houchen CW, Chandrakesan P, Rao CV. Correction: Panneerselvam et al. Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism. Cancers 2021, 13, 5159. Cancers (Basel). 2025 Jan 22; 17(3). PMID: 39895342; PMCID: PMC11788541.
      Citations:    
    12. Moore LL, Qu D, Sureban S, Mitchell S, Pitts K, Cooper N, Fazili J, Harty R, Oseini A, Ding K, Bronze M, Houchen CW. From Inflammation to Oncogenesis: Tracing Serum DCLK1 and miRNA Signatures in Chronic Liver Diseases. Int J Mol Sci. 2024 Jun 12; 25(12). PMID: 38928187; PMCID: PMC11203803.
      Citations: 1     Fields:    Translation:Humans
    13. Ajayi T, Moon G, Chen S, Pan S, Oseini A, Houchen C. Surging Liver Transplantation for Nonalcoholic Steatohepatitis from 2000-2022: A National Database Study. South Med J. 2024 Jun; 117(6):302-310. PMID: 38830583; PMCID: PMC11160975.
      Citations:    Fields:    Translation:Humans
    14. Liu M, Ren Y, Zhou Z, Yang J, Shi X, Cai Y, Arreola AX, Luo W, Fung KM, Xu C, Nipp RD, Bronze MS, Zheng L, Li YP, Houchen CW, Zhang Y, Li M. The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia. Cancer Cell. 2024 Mar 29. PMID: 38608702.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    15. Moore LL, Houchen CW. Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells. Int J Mol Sci. 2023 Nov 16; 24(22). PMID: 38003596; PMCID: PMC10671580.
      Citations:    Fields:    Translation:HumansCells
    16. Undi RB, Ahsan N, Larabee JL, Darlene-Reuter N, Papin J, Dogra S, Hannafon BN, Bronze MS, Houchen CW, Huycke MM, Ali N. Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network. J Virol. 2023 Oct 20; e0119423. PMID: 37861336.
      Citations: 1     Fields:    Translation:HumansCells
    17. Dogra S, Elayapillai SP, Qu D, Pitts K, Filatenkov A, Houchen CW, Berry WL, Moxley K, Hannafon BN. Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer. Cancer Lett. 2023 Oct 12; 216437. PMID: 37838282.
      Citations: 6     Fields:    Translation:HumansCells
    18. Zhou Z, Bonds MM, Edil BH, Houchen CW, Liu Z, Li M. Lysosomes Promote Cancer Metastasis via Exosome in PTEN-Deficient Tumors. Gastroenterology. 2023 03; 164(3):329-331. PMID: 36608713.
      Citations: 4     Fields:    Translation:HumansCells
    19. Zhou Z, Saluja AK, Houchen CW, Li M. Replication stress identifies novel molecular classification associated with treatment outcomes in pancreatic cancer. Pancreatology. 2022 Nov 21. PMID: 36435734.
      Citations:    Fields:    Translation:Humans
    20. Subramaniam D, May R, Sureban SM, Lee KB, George R, Kuppusamy P, Ramanujam RP, Hideg K, Dieckgraefe BK, Houchen CW, Anant S. Editor's Note: Diphenyl Difluoroketone: A Curcumin Derivative with Potent In Vivo Anticancer Activity. Cancer Res. 2022 Aug 16; 82(16):2951. PMID: 35971679.
      Citations: 1     Fields:    
    21. Undi RB, Larabee JL, Filiberti A, Ulahannan S, Aravindan S, Stroberg E, Barton LM, Duval EJ, Mukhopadhyay S, Henthorn JC, Akins D, Houchen CW, Huycke MM, Ali N. Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19. J Virol. 2022 09 14; 96(17):e0096722. PMID: 35943255; PMCID: PMC9472619.
      Citations: 4     Fields:    Translation:HumansCells
    22. Zhang Y, Houchen CW, Li M. Patient-Derived Organoid Pharmacotyping Guides Precision Medicine for Pancreatic Cancer. Clin Cancer Res. 2022 08 02; 28(15):3176-3178. PMID: 35617521.
      Citations: 5     Fields:    Translation:Humans
    23. Zhou Z, Ren Y, Yang J, Liu M, Shi X, Luo W, Fung KM, Xu C, Bronze MS, Zhang Y, Houchen CW, Li M. Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. Gastroenterology. 2022 11; 163(5):1281-1293.e1. PMID: 35777482.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    24. MacCuaig WM, Samykutty A, Foote J, Luo W, Filatenkov A, Li M, Houchen C, Grizzle WE, McNally LR. Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery. Pharmaceutics. 2022 Apr 30; 14(5). PMID: 35631554.
      Citations: 8     
    25. Bishnupuri KS, Sainathan SK, Ciorba MA, Houchen CW, Dieckgraefe BK. Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells. Mol Cancer Res. 2022 Mar 01; 20(3):387-399. PMID: 34753802.
      Citations: 10     Fields:    Translation:HumansCells
    26. Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M. Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-ß Signaling Axis in Pancreatic Cancer. Gastroenterology. 2022 06; 162(7):2004-2017.e2. PMID: 35176309.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    27. Zhang Y, Houchen CW, Li M. A Novel Translational Activation of HIF1a Promotes Pancreatic Cancer Growth Through Glycolytic Reprogramming. Gastroenterology. 2022 04; 162(4):1040-1042. PMID: 35120914.
      Citations: 1     Fields:    Translation:HumansCells
    28. Zhang Y, Houchen CW, Li M. Attenuating DNA damage response and immunosuppression radiosensitizes pancreatic cancer. EBioMedicine. 2022 Feb; 76:103822. PMID: 35065419.
      Citations: 5     Fields:    Translation:HumansCells
    29. Panneerselvam J, Madka V, Rai R, Morris KT, Houchen CW, Chandrakesan P, Rao CV. Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism. Cancers (Basel). 2021 Oct 14; 13(20). PMID: 34680308.
      Citations: 8     
    30. Zhang Y, Yang J, Bronze MS, Houchen CW, Li M. Interplay of Tumor Microenvironment Factors and Cancer Stem Cell Enrichment in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2021 12; 161(6):1800-1802. PMID: 34536452.
      Citations:    Fields:    Translation:HumansCells
    31. Zhou Z, Zhang J, Xu C, Yang J, Zhang Y, Liu M, Shi X, Li X, Zhan H, Chen W, McNally LR, Fung KM, Luo W, Houchen CW, He Y, Zhang C, Li M. An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer. EBioMedicine. 2021 Mar; 65:103271. PMID: 33714027.
      Citations: 31     Fields:    Translation:Humans
    32. Liu M, Zhang Y, Yang J, Zhan H, Zhou Z, Jiang Y, Shi X, Fan X, Zhang J, Luo W, Fung KA, Xu C, Bronze MS, Houchen CW, Li M. Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer. Gastroenterology. 2021 04; 160(5):1771-1783.e1. PMID: 33421513.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    33. Yarla NS, Pathuri G, Gali H, Terzyan S, Panneerselvam J, Chandrakesan P, Scotti MT, Houchen C, Madka V, Rao CV. Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. J Inflamm Res. 2020; 13:1261-1278. PMID: 33408499.
      Citations: 6     
    34. Cao Z, Weygant N, Chandrakesan P, Houchen CW, Peng J, Qu D. Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment. Cancers (Basel). 2020 Dec 17; 12(12). PMID: 33348546.
      Citations: 25     
    35. Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 2020 10 23; 370(6515):467-472. PMID: 33093110.
      Citations: 107     Fields:    Translation:AnimalsCells
    36. Moore LL, Zhou Z, Li M, Houchen CW. Tuft Cells Play Critical Roles in the Heterogeneity and Epithelial Plasticity in Pancreatic Cancer Initiation and Progression. Gastroenterology. 2020 11; 159(5):1657-1659. PMID: 32918911.
      Citations: 2     Fields:    Translation:Animals
    37. Houchen CW, Li M. A subset of epithelial cells mimics regulatory T cells and contributes to immune evasion during development of pancreatic adenocarcinoma. BMC Med. 2020 06 29; 18(1):155. PMID: 32594906.
      Citations: 1     Fields:    Translation:HumansCells
    38. Ali N, Nguyen CB, Chandrakesan P, Wolf RF, Qu D, May R, Goretsky T, Fazili J, Barrett TA, Li M, Huycke MM, Bronze MS, Houchen CW. Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical ß-catenin-dependent mechanism. Sci Rep. 2020 06 29; 10(1):10578. PMID: 32601309.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    39. Panneerselvam J, Mohandoss P, Patel R, Gillan H, Li M, Kumar K, Nguyen D, Weygant N, Qu D, Pitts K, Lightfoot S, Rao C, Houchen C, Bronze M, Chandrakesan P. DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4. Mol Ther Oncolytics. 2020 Sep 25; 18:24-36. PMID: 32637578.
      Citations: 22     
    40. Chandrakesan P, Panneerselvam J, May R, Weygant N, Qu D, Berry WR, Pitts K, Stanger BZ, Rao CV, Bronze MS, Houchen CW. DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization. Mol Cancer Ther. 2020 07; 19(7):1539-1549. PMID: 32371580.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    41. Wu X, Qu D, Weygant N, Peng J, Houchen CW. Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments. Cancers (Basel). 2020 Jan 22; 12(2). PMID: 31979136.
      Citations: 45     
    42. Sureban SM, Berahovich R, Zhou H, Xu S, Wu L, Ding K, May R, Qu D, Bannerman-Menson E, Golubovskaya V, Houchen CW. DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers. Cancers (Basel). 2019 Dec 23; 12(1). PMID: 31878090.
      Citations: 33     
    43. Liu M, Zhang Y, Yang J, Cui X, Zhou Z, Zhan H, Ding K, Tian X, Yang Z, Fung KA, Edil BH, Postier RG, Bronze MS, Fernandez-Zapico ME, Stemmler MP, Brabletz T, Li YP, Houchen CW, Li M. ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin a3ß1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells. Gastroenterology. 2020 02; 158(3):679-692.e1. PMID: 31711924.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    44. Qu D, Weygant N, Yao J, Chandrakesan P, Berry WL, May R, Pitts K, Husain S, Lightfoot S, Li M, Wang TC, An G, Clendenin C, Stanger BZ, Houchen CW. Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer. J Oncol. 2019; 2019:6402925. PMID: 31467540.
      Citations: 23     
    45. Christman EM, Chandrakesan P, Weygant N, Maple JT, Tierney WM, Vega KJ, Houchen CW. Elevated doublecortin-like kinase 1 serum levels revert to baseline after therapy in early stage esophageal adenocarcinoma. Biomark Res. 2019; 7:5. PMID: 30899515.
      Citations: 1     
    46. Yi J, Bergstrom K, Fu J, Shan X, McDaniel JM, McGee S, Qu D, Houchen CW, Liu X, Xia L. Dclk1 in tuft cells promotes inflammation-driven epithelial restitution and mitigates chronic colitis. Cell Death Differ. 2019 09; 26(9):1656-1669. PMID: 30478383.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    47. Yang J, Zhang Z, Zhang Y, Ni X, Zhang G, Cui X, Liu M, Xu C, Zhang Q, Zhu H, Yan J, Zhu VF, Luo Y, Hagan JP, Li Z, Fang J, Jatoi A, Fernandez-Zapico ME, Zheng L, Edil BH, Bronze MS, Houchen CW, Li YP, Li M. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. Gastroenterology. 2019 02; 156(3):722-734.e6. PMID: 30342032.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    48. Ge Y, Weygant N, Qu D, May R, Berry WL, Yao J, Chandrakesan P, Zheng W, Zhao L, Zhao KL, Drake M, Vega KJ, Bronze MS, Tomasek JJ, An G, Houchen CW. Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer. Int J Cancer. 2018 09 01; 143(5):1162-1175. PMID: 29577277.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    49. Liu M, Yang J, Zhang Y, Zhou Z, Cui X, Zhang L, Fung KM, Zheng W, Allard FD, Yee EU, Ding K, Wu H, Liang Z, Zheng L, Fernandez-Zapico ME, Li YP, Bronze MS, Morris KT, Postier RG, Houchen CW, Yang J, Li M. ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism. Clin Cancer Res. 2018 07 01; 24(13):3186-3196. PMID: 29615456.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    50. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. PMID: 28686870.
      Citations: 202     Fields:    Translation:AnimalsCells
    51. Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2017 02 01; 16(1):30. PMID: 28148261.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    52. Chandrakesan P, May R, Weygant N, Qu D, Berry WL, Sureban SM, Ali N, Rao C, Huycke M, Bronze MS, Houchen CW. Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep. 2016 11 23; 6:37667. PMID: 27876863.
      Citations: 26     Fields:    Translation:AnimalsCellsPHPublic Health
    53. Nguyen CB, Houchen CW, Ali N. APSA Awardee Submission: Tumor/cancer stem cell marker doublecortin-like kinase 1 in liver diseases. Exp Biol Med (Maywood). 2017 02; 242(3):242-249. PMID: 27694285.
      Citations: 3     Fields:    Translation:HumansCells
    54. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 08 15; 76(16):4887-96. PMID: 27287718.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    55. Weygant N, Ge Y, Qu D, Kaddis JS, Berry WL, May R, Chandrakesan P, Bannerman-Menson E, Vega KJ, Tomasek JJ, Bronze MS, An G, Houchen CW. Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase. Cancer Res. 2016 07 15; 76(14):4090-9. PMID: 27287716.
      Citations: 19     Fields:    Translation:HumansCells
    56. Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC. Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis. Cell Stem Cell. 2016 Apr 07; 18(4):441-55. PMID: 27058937.
      Citations: 127     Fields:    Translation:Animals
    57. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 07; 151(1):152-164.e11. PMID: 27059389.
      Citations: 83     Fields:    Translation:AnimalsCells
    58. Chandrakesan P, Panneerselvam J, Qu D, Weygant N, May R, Bronze MS, Houchen CW. Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells. J Carcinog Mutagen. 2016 Apr; 7(2). PMID: 27335684.
      Citations: 33     
    59. Liu L, Xu HX, Wang WQ, Wu CT, Xiang JF, Liu C, Long J, Xu J, Fu de L, Ni QX, Houchen CW, Postier RG, Li M, Yu XJ. Serum CA125 is a novel predictive marker for pancreatic cancer metastasis and correlates with the metastasis-associated burden. Oncotarget. 2016 Feb 02; 7(5):5943-56. PMID: 26745601.
      Citations: 55     Fields:    Translation:Humans
    60. Sureban SM, Madhoun MF, May R, Qu D, Ali N, Fazili J, Weygant N, Chandrakesan P, Ding K, Lightfoot SA, Houchen CW. Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism. Oncotarget. 2015 Nov 10; 6(35):37200-15. PMID: 26468984.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    61. Chandrakesan P, May R, Qu D, Weygant N, Taylor VE, Li JD, Ali N, Sureban SM, Qante M, Wang TC, Bronze MS, Houchen CW. Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal. Oncotarget. 2015 Oct 13; 6(31):30876-86. PMID: 26362399.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    62. Zhang Q, Sun X, Yang J, Ding H, LeBrun D, Ding K, Houchen CW, Postier RG, Ambrose CG, Li Z, Bi X, Li M. ZIP4 silencing improves bone loss in pancreatic cancer. Oncotarget. 2015 Sep 22; 6(28):26041-51. PMID: 26305676.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    63. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    64. Qu D, Weygant N, May R, Chandrakesan P, Madhoun M, Ali N, Sureban SM, An G, Schlosser MJ, Houchen CW. Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PLoS One. 2015; 10(8):e0134212. PMID: 26285154.
      Citations: 33     Fields:    Translation:AnimalsCells
    65. Kantara C, Moya SM, Houchen CW, Umar S, Ullrich RL, Singh P, Carney DH. Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Lab Invest. 2015 Nov; 95(11):1222-33. PMID: 26280221.
      Citations: 19     Fields:    Translation:AnimalsCells
    66. Sureban SM, May R, Qu D, Chandrakesan P, Weygant N, Ali N, Lightfoot SA, Ding K, Umar S, Schlosser MJ, Houchen CW. Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury. PLoS One. 2015; 10(8):e0135561. PMID: 26270561.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    67. Sureban SM, Qu D, Houchen CW. Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. Curr Pharmacol Rep. 2015 Aug 01; 1(4):217-222. PMID: 26366338.
      Citations: 8     
    68. Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV. Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget. 2015 Jun 20; 6(17):15524-39. PMID: 25906749.
      Citations: 26     Fields:    Translation:AnimalsCells
    69. Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW. Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells. PLoS One. 2015; 10(2):e0118933. PMID: 25723399.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    70. Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. Oncotarget. 2015 Feb 10; 6(4):2193-205. PMID: 25605241.
      Citations: 56     Fields:    Translation:HumansCells
    71. Dimas K, Tsimplouli C, Houchen C, Pantazis P, Sakellaridis N, Tsangaris GT, Anastasiadou E, Ramanujam RP. An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells. Altern Ther Health Med. 2015; 21 Suppl 2:46-54. PMID: 26308760.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    72. Chandrakesan P, Weygant N, May R, Qu D, Chinthalapally HR, Sureban SM, Ali N, Lightfoot SA, Umar S, Houchen CW. DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition. Oncotarget. 2014 Oct 15; 5(19):9269-80. PMID: 25211188.
      Citations: 57     Fields:    Translation:AnimalsCells
    73. Whorton J, Sureban SM, May R, Qu D, Lightfoot SA, Madhoun M, Johnson M, Tierney WM, Maple JT, Vega KJ, Houchen CW. DCLK1 is detectable in plasma of patients with Barrett's esophagus and esophageal adenocarcinoma. Dig Dis Sci. 2015 Feb; 60(2):509-13. PMID: 25283374.
      Citations: 20     Fields:    Translation:HumansCells
    74. Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X. Translational research on Barrett's esophagus. Ann N Y Acad Sci. 2014 Sep; 1325:170-86. PMID: 25266024.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    75. Le V, Syed S, Vega KJ, Sharma T, Madhoun MF, Srinivasan N, Houchen CW. Patient prompting of their physician resulted in increased colon cancer screening referrals. World J Gastrointest Oncol. 2014 Jul 15; 6(7):257-62. PMID: 25024817.
      Citations: 4     
    76. Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW. XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. Cancer Lett. 2014 Aug 28; 351(1):151-61. PMID: 24880079.
      Citations: 77     Fields:    Translation:AnimalsCells
    77. Ramachandran I, Ganapathy V, Gillies E, Fonseca I, Sureban SM, Houchen CW, Reis A, Queimado L. Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis. 2014 May 22; 5:e1246. PMID: 24853424.
      Citations: 36     Fields:    Translation:HumansCells
    78. Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103. PMID: 24885928.
      Citations: 65     Fields:    Translation:HumansCells
    79. Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest. 2014 Mar; 124(3):1283-95. PMID: 24487592.
      Citations: 247     Fields:    Translation:AnimalsCells
    80. May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Li L, Sureban SM, Houchen CW. Brief report: Dclk1 deletion in tuft cells results in impaired epithelial repair after radiation injury. Stem Cells. 2014 Mar; 32(3):822-7. PMID: 24123696.
      Citations: 55     Fields:    Translation:AnimalsCellsPHPublic Health
    81. Ong BA, Vega KJ, Houchen CW. Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol. 2014 Feb 28; 20(8):1898-909. PMID: 24587669.
      Citations: 23     Fields:    Translation:HumansCells
    82. Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 01; 306(5):G404-11. PMID: 24368703.
      Citations: 23     Fields:    Translation:AnimalsCells
    83. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365.
      Citations: 23     Fields:    Translation:HumansCells
    84. Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK. Reg4-induced mitogenesis involves Akt-GSK3ß-ß-Catenin-TCF-4 signaling in human colorectal cancer. Mol Carcinog. 2014 Feb; 53 Suppl 1:E169-80. PMID: 24151146.
      Citations: 18     Fields:    Translation:HumansCells
    85. Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG, Houchen CW. DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. PLoS One. 2013; 8(9):e73940. PMID: 24040120.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    86. Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH. A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G542-51. PMID: 23928185.
      Citations: 18     Fields:    Translation:AnimalsCells
    87. Chandrakesan P, Roy B, Jakkula LU, Ahmed I, Ramamoorthy P, Tawfik O, Papineni R, Houchen C, Anant S, Umar S. Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis. Oncogene. 2014 May 15; 33(20):2639-54. PMID: 23752178.
      Citations: 46     Fields:    Translation:AnimalsCells
    88. Qu D, Sureban SM, Houchen CW. Epigenetic variants and biomarkers for colon cancer. Am J Pathol. 2012 Jun; 180(6):2205-7. PMID: 22542494.
      Citations:    Fields:    Translation:Humans
    89. Vega KJ, May R, Sureban SM, Lightfoot SA, Qu D, Reed A, Weygant N, Ramanujam R, Souza R, Madhoun M, Whorton J, Anant S, Meltzer SJ, Houchen CW. Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol Hepatol. 2012 Apr; 27(4):773-80. PMID: 21916995.
      Citations: 39     Fields:    Translation:HumansCells
    90. Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1359-63. PMID: 22461030.
      Citations: 133     Fields:    Translation:HumansCells
    91. Pantazis P, Dimas K, Wyche JH, Anant S, Houchen CW, Panyam J, Ramanujam RP. Preparation of siRNA-encapsulated PLGA nanoparticles for sustained release of siRNA and evaluation of encapsulation efficiency. Methods Mol Biol. 2012; 906:311-9. PMID: 22791444.
      Citations: 14     Fields:    
    92. Sainathan SK, Bishnupuri KS, Aden K, Luo Q, Houchen CW, Anant S, Dieckgraefe BK. Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis. Inflamm Bowel Dis. 2012 May; 18(5):955-67. PMID: 21953855.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    93. Ali N, Allam H, May R, Sureban SM, Bronze MS, Bader T, Umar S, Anant S, Houchen CW. Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. J Virol. 2011 Dec; 85(23):12292-303. PMID: 21937640.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    94. Sureban SM, May R, Mondalek FG, Qu D, Ponnurangam S, Pantazis P, Anant S, Ramanujam RP, Houchen CW. Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology. 2011 Sep 19; 9:40. PMID: 21929751.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    95. Subramaniam D, Ramalingam S, Linehan DC, Dieckgraefe BK, Postier RG, Houchen CW, Jensen RA, Anant S. RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells. PLoS One. 2011 Feb 11; 6(2):e16958. PMID: 21347286.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    96. Sureban SM, May R, Lightfoot SA, Hoskins AB, Lerner M, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res. 2011 Mar 15; 71(6):2328-38. PMID: 21285251.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    97. Ponnurangam S, Mondalek FG, Govind J, Subramaniam D, Houchen CW, Anant S, Pantazis P, Ramanujam RP. Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay. In Vivo. 2010 Nov-Dec; 24(6):861-4. PMID: 21164045.
      Citations: 4     Fields:    Translation:HumansCells
    98. Mondalek FG, Ponnurangam S, Govind J, Houchen C, Anant S, Pantazis P, Ramanujam RP. Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP. J Nanobiotechnology. 2010 Jul 15; 8:17. PMID: 20633276.
      Citations: 8     Fields:    
    99. May R, Sureban SM, Lightfoot SA, Hoskins AB, Brackett DJ, Postier RG, Ramanujam R, Rao CV, Wyche JH, Anant S, Houchen CW. Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G303-10. PMID: 20522640.
      Citations: 50     Fields:    Translation:AnimalsCells
    100. Subramaniam D, Ramalingam S, Houchen CW, Anant S. Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem. 2010 May; 10(5):359-71. PMID: 20370703.
      Citations: 41     Fields:    Translation:HumansCells
    101. Anant S, Houchen CW, Pawar V, Ramalingam S. Role of RNA-Binding Proteins in Colorectal Carcinogenesis. Curr Colorectal Cancer Rep. 2010 Mar 02; 6(2):68-73. PMID: 20401169.
      Citations: 8     
    102. Pantazis P, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. Altern Ther Health Med. 2010 Mar-Apr; 16(2):12-4. PMID: 20232614.
      Citations: 5     Fields:    Translation:HumansAnimals
    103. Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, Gross JH, Aden K, May R, Houchen CW, Anant S, Dieckgraefe BK. Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis. Gastroenterology. 2010 Feb; 138(2):616-26, 626.e1-2. PMID: 19900450.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    104. May R, Sureban SM, Hoang N, Riehl TE, Lightfoot SA, Ramanujam R, Wyche JH, Anant S, Houchen CW. Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells. 2009 Oct; 27(10):2571-9. PMID: 19676123.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    105. Han Z, Dimas K, Tian X, Wang Y, Hemmi H, Yamada K, Kato N, Pantazis P, Ramanujam RJ, Anant S, Wyche JH, Houchen CW. 14-3-3sigma-dependent resistance to cisplatin. Anticancer Res. 2009 Jun; 29(6):2009-14. PMID: 19528459.
      Citations: 5     Fields:    Translation:HumansCells
    106. Sureban SM, May R, Ramalingam S, Subramaniam D, Natarajan G, Anant S, Houchen CW. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism. Gastroenterology. 2009 Aug; 137(2):649-59, 659.e1-2. PMID: 19445940.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    107. Anant S, Houchen CW. HuR and TTP: two RNA binding proteins that deliver message from the 3' end. Gastroenterology. 2009 May; 136(5):1495-8. PMID: 19327732.
      Citations: 9     Fields:    Translation:Humans
    108. George RJ, Sturmoski MA, May R, Sureban SM, Dieckgraefe BK, Anant S, Houchen CW. Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G245-54. PMID: 19056768.
      Citations: 12     Fields:    Translation:AnimalsCells
    109. Wang X, Allen TD, May RJ, Lightfoot S, Houchen CW, Huycke MM. Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect. Cancer Res. 2008 Dec 01; 68(23):9909-17. PMID: 19047172.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    110. Subramaniam D, Giridharan P, Murmu N, Shankaranarayanan NP, May R, Houchen CW, Ramanujam RP, Balakrishnan A, Vishwakarma RA, Anant S. Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. Cancer Res. 2008 Oct 15; 68(20):8573-81. PMID: 18922933.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    111. Allen TD, Moore DR, Wang X, Casu V, May R, Lerner MR, Houchen C, Brackett DJ, Huycke MM. Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. J Med Microbiol. 2008 Oct; 57(Pt 10):1193-1204. PMID: 18809545.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    112. Sureban SM, Ramalingam S, Natarajan G, May R, Subramaniam D, Bishnupuri KS, Morrison AR, Dieckgraefe BK, Brackett DJ, Postier RG, Houchen CW, Anant S. Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe. Oncogene. 2008 Jul 31; 27(33):4544-56. PMID: 18427544.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    113. Subramaniam D, May R, Sureban SM, Lee KB, George R, Kuppusamy P, Ramanujam RP, Hideg K, Dieckgraefe BK, Houchen CW, Anant S. Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer Res. 2008 Mar 15; 68(6):1962-9. PMID: 18339878.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    114. Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, Anant S. CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1235-44. PMID: 18325984.
      Citations: 19     Fields:    Translation:HumansCells
    115. Sureban SM, May R, George RJ, Dieckgraefe BK, McLeod HL, Ramalingam S, Bishnupuri KS, Natarajan G, Anant S, Houchen CW. Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo. Gastroenterology. 2008 May; 134(5):1448-58. PMID: 18471519.
      Citations: 97     Fields:    Translation:HumansAnimals
    116. Subramaniam D, Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, Anant S. Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1025-32. PMID: 18292181.
      Citations: 41     Fields:    Translation:HumansCells
    117. Ramalingam S, Natarajan G, Schafer C, Subramaniam D, May R, Ramachandran I, Queimado L, Houchen CW, Anant S. Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G971-81. PMID: 18258790.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    118. Subramaniam D, Ramalingam S, May R, Dieckgraefe BK, Berg DE, Pothoulakis C, Houchen CW, Wang TC, Anant S. Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. Gastroenterology. 2008 Apr; 134(4):1070-82. PMID: 18395088.
      Citations: 32     Fields:    Translation:HumansCells
    119. Sainathan SK, Hanna EM, Gong Q, Bishnupuri KS, Luo Q, Colonna M, White FV, Croze E, Houchen C, Anant S, Dieckgraefe BK. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis. 2008 Jan; 14(1):88-99. PMID: 17932977.
      Citations: 63     Fields:    Translation:AnimalsCells
    120. May R, Riehl TE, Hunt C, Sureban SM, Anant S, Houchen CW. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells. 2008 Mar; 26(3):630-7. PMID: 18055444.
      Citations: 165     Fields:    Translation:AnimalsCells
    121. Vyas D, Robertson CM, Stromberg PE, Martin JR, Dunne WM, Houchen CW, Barrett TA, Ayala A, Perl M, Buchman TG, Coopersmith CM. Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine. Histol Histopathol. 2007 06; 22(6):623-30. PMID: 17357092.
      Citations: 47     Fields:    Translation:Animals
    122. George RJ, Sturmoski MA, Anant S, Houchen CW. EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat. 2007 Feb; 83(1-2):112-20. PMID: 17259077.
      Citations: 38     Fields:    Translation:HumansCells
    123. Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK. Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. Cancer Biol Ther. 2006 Dec; 5(12):1714-20. PMID: 17106246.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    124. Sureban SM, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe BK, Houchen CW, Anant S. Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation. Gastroenterology. 2007 Mar; 132(3):1055-65. PMID: 17383427.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    125. Riehl TE, George RJ, Sturmoski MA, May R, Dieckgraefe B, Anant S, Houchen CW. Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1062-70. PMID: 17038629.
      Citations: 6     Fields:    Translation:AnimalsCells
    126. Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S, Dieckgraefe BK. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology. 2006 Jan; 130(1):137-49. PMID: 16401477.
      Citations: 54     Fields:    Translation:HumansCells
    127. Sainathan SK, Tu L, Bishnupuri KS, Han M, Li A, Newberry RD, McDonald KG, Crimmins DL, Houchen C, Anant S, Dieckgraefe BK. PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization. Protein Expr Purif. 2005 Dec; 44(2):94-103. PMID: 16213750.
      Citations: 7     Fields:    Translation:AnimalsCells
    128. Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, Young SG, Morrison AR, Stenson WF, Davidson NO. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology. 2004 Oct; 127(4):1139-49. PMID: 15480992.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    129. Murmu N, Jung J, Mukhopadhyay D, Houchen CW, Riehl TE, Stenson WF, Morrison AR, Arumugam T, Dieckgraefe BK, Anant S. Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13873-8. PMID: 15358864.
      Citations: 16     Fields:    Translation:Animals
    130. Mukhopadhyay D, Jung J, Murmu N, Houchen CW, Dieckgraefe BK, Anant S. CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. Ann N Y Acad Sci. 2003 Dec; 1010:504-9. PMID: 15033780.
      Citations: 24     Fields:    Translation:HumansCells
    131. Houchen CW. FGF-20: FGFs--they keep growing and growing and growing! Inflamm Bowel Dis. 2003 Mar; 9(2):133. PMID: 12769450.
      Citations:    Fields:    Translation:AnimalsCells
    132. Mukhopadhyay D, Houchen CW, Kennedy S, Dieckgraefe BK, Anant S. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. Mol Cell. 2003 Jan; 11(1):113-26. PMID: 12535526.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    133. Houchen CW, Sturmoski MA, Anant S, Breyer RM, Stenson WF. Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G490-8. PMID: 12431904.
      Citations: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    134. Dieckgraefe BK, Crimmins DL, Landt V, Houchen C, Anant S, Porche-Sorbet R, Ladenson JH. Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity. J Investig Med. 2002 Nov; 50(6):421-34. PMID: 12425429.
      Citations: 36     Fields:    Translation:HumansCells
    135. Houchen CW. Clinical implications of prostaglandin inhibition in the small bowel. Gastroenterol Clin North Am. 2001 Dec; 30(4):953-69. PMID: 11764537.
      Citations:    Fields:    Translation:HumansAnimals
    136. Houchen CW, Stenson WF, Cohn SM. Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury. Am J Physiol Gastrointest Liver Physiol. 2000 Nov; 279(5):G858-65. PMID: 11052981.
      Citations: 22     Fields:    Translation:AnimalsCellsPHPublic Health
    137. Houchen CW, Stenson WF. Cyclooxygenase expression in intestinal epithelial cells. Curr Opin Gastroenterol. 1999 Mar; 15(2):97-9. PMID: 17023926.
      Citations: 1     Fields:    
    138. Houchen CW, George RJ, Sturmoski MA, Cohn SM. FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury. Am J Physiol. 1999 01; 276(1):G249-58. PMID: 9887002.
      Citations: 51     Fields:    Translation:HumansAnimalsCellsPHPublic Health
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