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David Patrick Sparling

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Pediatrics
AddressOUCPB 4500
1200 Children's Ave
Oklahoma City OK 73104
Phone405/271-8001 ext 43093
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    K08DK115797     (SPARLING, DAVID)Sep 7, 2017 - Aug 31, 2021
    The role of adipocyte gamma-secretase in regulation of inflammatory signaling
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Noor N, Ebekozien O, Levin L, Stone S, Sparling DP, Rapaport R, Maahs DM. Diabetes Technology Use for Management of Type 1 Diabetes Is Associated With Fewer Adverse COVID-19 Outcomes: Findings From the T1D Exchange COVID-19 Surveillance Registry. Diabetes Care. 2021 08; 44(8):e160-e162. PMID: 34385347.
      Citations: 8     Fields:    Translation:HumansCells
    2. Sparling DP, McCullough N, Pajvani U, Humphrey MB. Inhibition of ?-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation. Adipocyte. 2020 12; 9(1):325-334. PMID: 32603641.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Jackson RM, Griesel BA, Short KR, Sparling D, Freeman WM, Olson AL. Weight Loss Results in Increased Expression of Anti-Inflammatory Protein CRISPLD2 in Mouse Adipose Tissue. Obesity (Silver Spring). 2019 12; 27(12):2025-2036. PMID: 31746554.
      Citations: 5     Fields:    Translation:Animals
    4. Tryggestad JB, Teague AM, Sparling DP, Jiang S, Chernausek SD. Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma. Obesity (Silver Spring). 2019 11; 27(11):1856-1864. PMID: 31531958.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    5. Sparling DP, Fabian K, Harik L, Jobanputra V, Anyane-Yeboa K, Oberfield SE, Fennoy I. Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase. J Pediatr Endocrinol Metab. 2016 May 01; 29(5):627-31. PMID: 26894573.
      Citations: 1     Fields:    Translation:Humans
    6. Kim K, Qiang L, Hayden MS, Sparling DP, Purcell NH, Pajvani UB. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nat Commun. 2016 Jan 08; 7:10255. PMID: 26743335.
      Citations: 37     Fields:    Translation:AnimalsCells
    7. Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, Pajvani UB. Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. Mol Metab. 2016 Feb; 5(2):113-121. PMID: 26909319.
      Citations: 12     Fields:    
    8. Sparling DP, Griesel BA, Weems J, Olson AL. GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes. J Biol Chem. 2008 Mar 21; 283(12):7429-37. PMID: 18216015.
      Citations: 21     Fields:    Translation:AnimalsCells
    9. Sparling DP, Griesel BA, Olson AL. Hyperphosphorylation of MEF2A in primary adipocytes correlates with downregulation of human GLUT4 gene promoter activity. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1149-56. PMID: 17164432.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. McGee SL, Sparling D, Olson AL, Hargreaves M. Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle. FASEB J. 2006 Feb; 20(2):348-9. PMID: 16368714.
      Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
    11. Holmes BF, Sparling DP, Olson AL, Winder WW, Dohm GL. Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1071-6. PMID: 16105857.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    12. Janiak-Spens F, Sparling DP, West AH. Novel role for an HPt domain in stabilizing the phosphorylated state of a response regulator domain. J Bacteriol. 2000 Dec; 182(23):6673-8. PMID: 11073911.
      Citations: 29     Fields:    Translation:AnimalsCells
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