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Lauren A Zenewicz

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBMSB 1034
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-2133 ext 46618
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    R01AI173108     (ZENEWICZ, LAUREN A)Aug 1, 2023 - Jul 31, 2028
    Understanding and leveraging immunometabolism to combat Clostridioides difficile infection
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sah P, Knighten BA, Reidy MA, Zenewicz LA. Polyamines and hypusination are important for Clostridioides difficile toxin B (TcdB)-mediated activation of group 3 innate lymphocytes (ILC3s). Infect Immun. 2023 Oct 20; e0023623. PMID: 37861311.
      Citations:    Fields:    Translation:HumansCells
    2. Sah P, Zenewicz LA. Modulation of innate lymphoid cells by enteric bacterial pathogens. Front Immunol. 2023; 14:1219072. PMID: 37483638; PMCID: PMC10358831.
      Citations:    Fields:    Translation:HumansCells
    3. Yashchenko A, Bland SJ, Song CJ, Ahmed UKB, Sharp R, Darby IG, Cordova AM, Smith ME, Lever JM, Li Z, Aloria EJ, Khan S, Maryam B, Liu S, Crowley MR, Jones KL, Zenewicz LA, George JF, Mrug M, Crossman DK, Hopp K, Stavrakis S, Humphrey MB, Ginhoux F, Zimmerman KA. Cx3cr1 controls kidney resident macrophage heterogeneity. Front Immunol. 2023; 14:1082078. PMID: 37256130; PMCID: PMC10225589.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Sah P, Zenewicz LA. The Polyamine Putrescine Is a Positive Regulator of Group 3 Innate Lymphocyte Activation. Immunohorizons. 2023 01 01; 7(1):41-48. PMID: 36637514.
      Citations: 2     Fields:    Translation:Animals
    5. Pope RL, Chitrakar A, Sah P, Shadid T, Ballard JD, Zenewicz LA. Clostridioides difficile Toxin B Activates Group 3 Innate Lymphocytes. Infect Immun. 2022 04 21; 90(4):e0007322. PMID: 35377172.
      Citations: 2     Fields:    Translation:HumansCells
    6. Sah P, Derouen JT, Alexander JL, Zenewicz LA. Group 3 innate lymphocytes (ILC3s) upregulate IL-22 in response to elevated intracellular cAMP levels. Cytokine. 2022 05; 153:155862. PMID: 35306427.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Zenewicz LA. IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology. Front Immunol. 2021; 12:766586. PMID: 34868019.
      Citations: 9     Fields:    Translation:Humans
    8. Chitrakar A, Budda SA, Henderson JG, Axtell RC, Zenewicz LA. E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation. J Immunol. 2020 08 15; 205(4):1009-1023. PMID: 32690659.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Seshadri S, Pope RL, Zenewicz LA. Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production. J Immunol. 2018 08 15; 201(4):1267-1274. PMID: 29980608.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    10. Zenewicz LA. IL-22: There Is a Gap in Our Knowledge. Immunohorizons. 2018 07 05; 2(6):198-207. PMID: 31022687.
      Citations: 46     Fields:    Translation:HumansAnimals
    11. Budda SA, Zenewicz LA. IL-22 deficiency increases CD4 T cell responses to mucosal immunization. Vaccine. 2018 06 14; 36(25):3694-3700. PMID: 29739717.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA. Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. PLoS Pathog. 2017 Oct; 13(10):e1006690. PMID: 29059238.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Zenewicz LA. Oxygen Levels and Immunological Studies. Front Immunol. 2017; 8:324. PMID: 28377771.
      Citations: 18     Fields:    
    14. Budda SA, Bhattarai K, Alexander JL, Zenewicz LA. Hypoxic modulation of hepatocyte responses to the cytokine interleukin-22. Immunol Cell Biol. 2017 04; 95(4):380-387. PMID: 27796296.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Budda SA, Girton A, Henderson JG, Zenewicz LA. Transcription Factor HIF-1a Controls Expression of the Cytokine IL-22 in CD4 T Cells. J Immunol. 2016 10 01; 197(7):2646-52. PMID: 27534553.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 07; 151(1):152-164.e11. PMID: 27059389.
      Citations: 66     Fields:    Translation:AnimalsCells
    17. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2016 Feb 25; 530(7591):504. PMID: 26605525.
      Citations: 5     Fields:    
    18. Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, Flavell RA. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J Immunol. 2013 May 15; 190(10):5306-12. PMID: 23585682.
      Citations: 145     Fields:    Translation:AnimalsCells
    19. Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA. Excessive Th1 responses due to the absence of TGF-ß signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6961-6. PMID: 23569233.
      Citations: 47     Fields:    Translation:AnimalsCells
    20. Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 08; 491(7423):259-63. PMID: 23075849.
      Citations: 340     Fields:    Translation:AnimalsCells
    21. Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One. 2012; 7(8):e44153. PMID: 22952908.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    22. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25; 484(7395):510-3. PMID: 22538615.
      Citations: 61     Fields:    Translation:AnimalsCells
    23. Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Feb 24; 36(2):276-87. PMID: 22306017.
      Citations: 248     Fields:    Translation:AnimalsCells
    24. Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med. 2011 May 09; 208(5):1027-40. PMID: 21518800.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    25. Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol. 2011 Mar; 23(3):159-63. PMID: 21393631.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    26. O'Connor W, Zenewicz LA, Flavell RA. The dual nature of T(H)17 cells: shifting the focus to function. Nat Immunol. 2010 Jun; 11(6):471-6. PMID: 20485275.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    27. Zenewicz LA, Abraham C, Flavell RA, Cho JH. Unraveling the genetics of autoimmunity. Cell. 2010 Mar 19; 140(6):791-7. PMID: 20303870.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    28. Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis. 2010 Feb 15; 201(4):534-43. PMID: 20064069.
      Citations: 137     Fields:    Translation:AnimalsCells
    29. Priatel JJ, Chen X, Huang YH, Chow MT, Zenewicz LA, Coughlin JJ, Shen H, Stone JC, Tan R, Teh HS. RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells. J Immunol. 2010 Jan 15; 184(2):666-76. PMID: 20007535.
      Citations: 15     Fields:    Translation:AnimalsCells
    30. Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA. Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol. 2009 Aug; 9(4):447-53. PMID: 19481975.
      Citations: 251     Fields:    Translation:HumansAnimals
    31. Zenewicz LA, Antov A, Flavell RA. CD4 T-cell differentiation and inflammatory bowel disease. Trends Mol Med. 2009 May; 15(5):199-207. PMID: 19362058.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    32. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 2008 Dec 19; 29(6):947-57. PMID: 19100701.
      Citations: 395     Fields:    Translation:HumansAnimalsCells
    33. Zenewicz LA, Flavell RA. IL-22 and inflammation: leukin' through a glass onion. Eur J Immunol. 2008 Dec; 38(12):3265-8. PMID: 19016525.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    34. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 2007 Oct; 27(4):647-59. PMID: 17919941.
      Citations: 300     Fields:    Translation:AnimalsCells
    35. Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15; 179(4):2143-52. PMID: 17675473.
      Citations: 20     Fields:    Translation:AnimalsCells
    36. Zenewicz LA, Shen H. Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect. 2007 Aug; 9(10):1208-15. PMID: 17719259.
      Citations: 86     Fields:    Translation:AnimalsCells
    37. Wei Z, Schnupf P, Poussin MA, Zenewicz LA, Shen H, Goldfine H. Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis. Infect Immun. 2005 Oct; 73(10):6639-46. PMID: 16177340.
      Citations: 15     Fields:    Translation:AnimalsCells
    38. Wei Z, Zenewicz LA, Goldfine H. Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12927-31. PMID: 16118276.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Eynon EE, Zenewicz LA, Flavell RA. Sugar-coated regulation of T cells. Cell. 2005 Jul 15; 122(1):2-4. PMID: 16009124.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    40. Zenewicz LA, Wei Z, Goldfine H, Shen H. Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response. J Immunol. 2005 Jun 15; 174(12):8011-6. PMID: 15944308.
      Citations: 11     Fields:    Translation:AnimalsCells
    41. Zenewicz LA, Skinner JA, Goldfine H, Shen H. Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes. Mol Microbiol. 2004 Mar; 51(5):1483-92. PMID: 14982640.
      Citations:    Fields:    Translation:AnimalsCells
    42. Jiang J, Zenewicz LA, San Mateo LR, Lau LL, Shen H. Activation of antigen-specific CD8 T cells results in minimal killing of bystander bacteria. J Immunol. 2003 Dec 01; 171(11):6032-8. PMID: 14634115.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Zenewicz LA, Foulds KE, Jiang J, Fan X, Shen H. Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens. J Immunol. 2002 Nov 15; 169(10):5805-12. PMID: 12421961.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Foulds KE, Zenewicz LA, Shedlock DJ, Jiang J, Troy AE, Shen H. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol. 2002 Feb 15; 168(4):1528-32. PMID: 11823476.
      Citations: 163     Fields:    Translation:AnimalsCells
    45. Weiser JN, Bae D, Epino H, Gordon SB, Kapoor M, Zenewicz LA, Shchepetov M. Changes in availability of oxygen accentuate differences in capsular polysaccharide expression by phenotypic variants and clinical isolates of Streptococcus pneumoniae. Infect Immun. 2001 Sep; 69(9):5430-9. PMID: 11500414.
      Citations: 58     Fields:    Translation:HumansCells
    46. Stermitz FR, Tawara-Matsuda J, Lorenz P, Mueller P, Zenewicz L, Lewis K. 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. J Nat Prod. 2000 Aug; 63(8):1146-9. PMID: 10978214.
      Citations: 21     Fields:    Translation:AnimalsCells
    47. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1433-7. PMID: 10677479.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
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