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Lijun Xia

TitleProf, Adjunct
InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research
Address825 N.E. 13th Street
Oklahoma City OK 73104
Phone405/271-7892
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    Collapse Research 
    Collapse research activities and funding
    P01HL085607     (MCEVER, RODGER PAUL)Jul 1, 2006 - May 31, 2017
    NIH
    Protein-glycan interactions in the vascular system
    Role: Co-Principal Investigator

    R01DK085691     (XIA, LIJUN)Aug 1, 2010 - Apr 30, 2021
    NIH
    Role of Mucin-type O-glycans in Intestinal Inflammation
    Role: Principal Investigator

    R01HD083418     (XIA, LIJUN)Aug 7, 2015 - Apr 30, 2021
    NIH
    Podoplanin-mediated platelet activation and vascular integrity in the developing brain
    Role: Principal Investigator

    R01HL128390     (XIA, LIJUN)Apr 1, 2016 - Mar 31, 2020
    NIH
    Platelet CLEC-2 regulation of vascular integrity during inflammation
    Role: Principal Investigator

    R01HL149860     (XIA, LIJUN)Jul 1, 2020 - Jun 30, 2024
    NIH
    Platelet CLEC-2 in Arterial Thrombosis
    Role: Principal Investigator

    R01HL153728     (XIA, LIJUN)Aug 1, 2020 - May 31, 2024
    NIH
    Site-1 protease-mediated lipid metabolism in lymphatic vascular development
    Role: Principal Investigator

    P20GM139763     (XIA, LIJUN)Feb 5, 2021 - Jan 31, 2026
    NIH
    Center for Cellular Metabolism Research in Oklahoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hoover C, Kondo Y, Shao B, McDaniel MJ, Lee R, McGee S, Whiteheart S, Bergmeier W, McEver RP, Xia L. Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood. 2021 May 20; 137(20):2756-2769. PMID: 33619517.
      Citations:    Fields:    
    2. Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 2020 10 23; 370(6515):467-472. PMID: 33093110.
      Citations: 6     Fields:    Translation:AnimalsCells
    3. Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018 07 26; 3(14). PMID: 30046013.
      Citations: 8     Fields:    Translation:HumansCells
    4. Ghafoory S, Varshney R, Robison T, Kouzbari K, Woolington S, Murphy B, Xia L, Ahamed J. Platelet TGF-ß1 deficiency decreases liver fibrosis in a mouse model of liver injury. Blood Adv. 2018 03 13; 2(5):470-480. PMID: 29490978.
      Citations: 16     Fields:    Translation:AnimalsCells
    5. Xia L. Platelet CLEC-2: a molecule with 2 faces. Blood. 2017 11 16; 130(20):2158-2160. PMID: 29146820.
      Citations: 1     Fields:    Translation:HumansCells
    6. Song K, Fu J, Song J, Herzog BH, Bergstrom K, Kondo Y, McDaniel JM, McGee S, Silasi-Mansat R, Lupu F, Chen H, Bagavant H, Xia L. Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. J Biol Chem. 2017 10 06; 292(40):16491-16497. PMID: 28842487.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D'souza P, Xia L, Zhu C, McEver RP. L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 05 12; 8:15196. PMID: 28497779.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2017 02 01; 16(1):30. PMID: 28148261.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS. Mechanotransduction activates canonical Wnt/ß-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 06 15; 30(12):1454-69. PMID: 27313318.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    10. Gao N, Bergstrom K, Fu J, Xie B, Chen W, Xia L. Loss of intestinal O-glycans promotes spontaneous duodenal tumors. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G74-83. PMID: 27229122.
      Citations: 9     Fields:    Translation:AnimalsCells
    11. Bergstrom K, Fu J, Johansson ME, Liu X, Gao N, Wu Q, Song J, McDaniel JM, McGee S, Chen W, Braun J, Hansson GC, Xia L. Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol. 2017 01; 10(1):91-103. PMID: 27143302.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    12. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 07; 151(1):152-164.e11. PMID: 27059389.
      Citations: 39     Fields:    Translation:AnimalsCells
    13. Fu J, Xia L. CLEC-2 and podoplanin, partners again. Blood. 2016 Mar 31; 127(13):1629-30. PMID: 27034419.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MKM, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 01; 409(1):218-233. PMID: 26542011.
      Citations: 24     Fields:    Translation:AnimalsCells
    15. Shao B, Yago T, Setiadi H, Wang Y, Mehta-D'souza P, Fu J, Crocker PR, Rodgers W, Xia L, McEver RP. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8661-6. PMID: 26124096.
      Citations: 21     Fields:    Translation:AnimalsCells
    16. Song K, Herzog BH, Fu J, Sheng M, Bergstrom K, McDaniel JM, Kondo Y, McGee S, Cai X, Li P, Chen H, Xia L. Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice. J Biol Chem. 2015 Aug 14; 290(33):20159-66. PMID: 26124270.
      Citations: 11     Fields:    Translation:AnimalsCells
    17. Chang B, Tessneer KL, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy ML, Rahman R, Ma JX, Xia L, Chen H. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015 Mar 16; 6:6380. PMID: 25871009.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Pan Y, Yago T, Fu J, Herzog B, McDaniel JM, Mehta-D'Souza P, Cai X, Ruan C, McEver RP, West C, Dai K, Chen H, Xia L. Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood. 2014 Dec 04; 124(24):3656-65. PMID: 25336627.
      Citations: 20     Fields:    Translation:AnimalsCells
    19. Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 2014 Oct 14; 7(347):ra97. PMID: 25314967.
      Citations: 19     Fields:    Translation:AnimalsCells
    20. Herzog BH, Fu J, Xia L. Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology. 2014 Dec; 24(12):1237-41. PMID: 24946788.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Chen H, Griffin C, Xia L, Srinivasan RS. Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res. 2014 Nov; 96:16-22. PMID: 24928499.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol. 2014 Feb; 34(2):331-337. PMID: 24311377.
      Citations: 25     Fields:    Translation:AnimalsCells
    23. Song K, Herzog BH, Sheng M, Fu J, McDaniel JM, Chen H, Ruan J, Xia L. Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res. 2013 Dec 15; 73(24):7254-64. PMID: 24158094.
      Citations: 18     Fields:    Translation:HumansAnimals
    24. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. PMID: 23995678.
      Citations: 107     Fields:    Translation:AnimalsCells
    25. Bergstrom KS, Xia L. Mucin-type O-glycans and their roles in intestinal homeostasis. Glycobiology. 2013 Sep; 23(9):1026-37. PMID: 23752712.
      Citations: 70     Fields:    Translation:Humans
    26. Kim YM, Lee JY, Xia L, Mulvihill JJ, Li S. Trisomy 8: a common finding in mouse embryonic stem (ES) cell lines. Mol Cytogenet. 2013 Jan 16; 6(1):3. PMID: 23320952.
      Citations:    
    27. Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38. PMID: 23187125.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    28. Wang S, Zhang C, Zhang M, Liang B, Zhu H, Lee J, Viollet B, Xia L, Zhang Y, Zou MH. Activation of AMP-activated protein kinase a2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med. 2012 Jun; 18(6):902-10. PMID: 22561688.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    29. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. PMID: 21860019.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    30. Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest. 2011 Apr; 121(4):1657-66. PMID: 21383503.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    31. Miner JJ, Shao B, Wang Y, Chichili GR, Liu Z, Klopocki AG, Yago T, McDaniel JM, Rodgers W, Xia L, McEver RP. Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem. 2011 Mar 18; 286(11):9577-86. PMID: 21220419.
      Citations: 7     Fields:    Translation:AnimalsCells
    32. Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, McEver RP. Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med. 2010 Dec 20; 207(13):2975-87. PMID: 21149548.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    33. Yago T, Fu J, McDaniel JM, Miner JJ, McEver RP, Xia L. Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9204-9. PMID: 20439727.
      Citations: 35     Fields:    Translation:AnimalsCells
    34. Xia L. Core 3-derived O-glycans are essential for intestinal mucus barrier function. Methods Enzymol. 2010; 479:123-41. PMID: 20816163.
      Citations: 9     Fields:    Translation:Animals
    35. Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov; 118(11):3725-37. PMID: 18924607.
      Citations: 100     Fields:    Translation:AnimalsCells
    36. Miner JJ, Xia L, Yago T, Kappelmayer J, Liu Z, Klopocki AG, Shao B, McDaniel JM, Setiadi H, Schmidtke DW, McEver RP. Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood. 2008 Sep 01; 112(5):2035-45. PMID: 18550846.
      Citations: 52     Fields:    Translation:AnimalsCells
    37. An G, Wang H, Tang R, Yago T, McDaniel JM, McGee S, Huo Y, Xia L. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation. 2008 Jun 24; 117(25):3227-37. PMID: 18519846.
      Citations: 68     Fields:    Translation:AnimalsCells
    38. An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med. 2007 Jun 11; 204(6):1417-29. PMID: 17517967.
      Citations: 133     Fields:    Translation:Animals
    39. Xia L, McEver RP. Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice. Methods Enzymol. 2006; 416:314-31. PMID: 17113876.
      Citations: 13     Fields:    Translation:AnimalsCells
    40. Yao L, Yokota T, Xia L, Kincade PW, McEver RP. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood. 2005 Dec 15; 106(13):4093-101. PMID: 16118327.
      Citations: 37     Fields:    Translation:AnimalsCells
    41. Xia L, McDaniel JM, Yago T, Doeden A, McEver RP. Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood. 2004 Nov 15; 104(10):3091-6. PMID: 15280192.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    42. Xia L, Ju T, Westmuckett A, An G, Ivanciu L, McDaniel JM, Lupu F, Cummings RD, McEver RP. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J Cell Biol. 2004 Feb 02; 164(3):451-9. PMID: 14745002.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    43. Xia L, Ramachandran V, McDaniel JM, Nguyen KN, Cummings RD, McEver RP. N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood. 2003 Jan 15; 101(2):552-9. PMID: 12393631.
      Citations: 28     Fields:    Translation:AnimalsCells
    44. Xia L, Sperandio M, Yago T, McDaniel JM, Cummings RD, Pearson-White S, Ley K, McEver RP. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest. 2002 Apr; 109(7):939-50. PMID: 11927621.
      Citations: 86     Fields:    Translation:AnimalsCells
    45. Yao L, Setiadi H, Xia L, Laszik Z, Taylor FB, McEver RP. Divergent inducible expression of P-selectin and E-selectin in mice and primates. Blood. 1999 Dec 01; 94(11):3820-8. PMID: 10572097.
      Citations: 37     Fields:    Translation:HumansAnimals
    46. Pan J, Xia L, McEver RP. Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells. J Biol Chem. 1998 Apr 17; 273(16):10058-67. PMID: 9545353.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    47. Pan J, Xia L, Yao L, McEver RP. Tumor necrosis factor-alpha- or lipopolysaccharide-induced expression of the murine P-selectin gene in endothelial cells involves novel kappaB sites and a variant activating transcription factor/cAMP response element. J Biol Chem. 1998 Apr 17; 273(16):10068-77. PMID: 9545354.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    48. Xia L, Pan J, Yao L, McEver RP. A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P-selectin in human endothelial cells. Blood. 1998 Mar 01; 91(5):1625-32. PMID: 9473228.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
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