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Lorin E Olson

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research
Addressn/a
825 N.E. 13th Street
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01AR080896     (OLSON, LORIN E)Feb 8, 2023 - Jan 31, 2028
    NIH
    PDGFRB Signaling in Progressive Skin Disease
    Role: Principal Investigator
    R01AR073828     (OLSON, LORIN E)Aug 12, 2019 - Apr 30, 2024
    NIH
    PDGF-regulated stem cells and bone disease
    Role: Principal Investigator
    R01AR070235     (OLSON, LORIN E)Sep 1, 2016 - Aug 31, 2021
    NIH
    PDGF-regulated cell fate and dermal fibrosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang J, Zhu L, Pan H, Ueharu H, Toda M, Yang Q, Hallett SA, Olson LE, Mishina Y. A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11; 134(8). PMID: 38466355; PMCID: PMC11014657.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Yao L, Jeong S, Kwon HR, Olson LE. Regulation of adipocyte dedifferentiation at the skin wound edge. bioRxiv. 2023 Nov 22. PMID: 38045303; PMCID: PMC10690246.
      Citations:    
    3. Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, L?pez-Andr?s N, Bischoff J, Yutzey KE, Srinivasan RS. PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves. Circ Res. 2023 09; 133(6):463-480. PMID: 37555328; PMCID: PMC10487359.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Iwayama T, Iwashita M, Miyashita K, Sakashita H, Matsumoto S, Tomita K, Bhongsatiern P, Kitayama T, Ikegami K, Shimbo T, Tamai K, Murayama MA, Ogawa S, Iwakura Y, Yamada S, Olson LE, Takedachi M, Murakami S. Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament. Development. 2022 Oct 01; 149(19). PMID: 36245218.
      Citations: 5     Fields:    Translation:AnimalsCells
    5. Yao L, Rathnakar BH, Kwon HR, Sakashita H, Kim JH, Rackley A, Tomasek JJ, Berry WL, Olson LE. Temporal control of PDGFRa regulates the fibroblast-to-myofibroblast transition in wound healing. Cell Rep. 2022 08 16; 40(7):111192. PMID: 35977484; PMCID: PMC9423027.
      Citations: 18     Fields:    Translation:AnimalsCells
    6. Kwon HR, Kim JH, Woods JP, Olson LE. Skeletal stem cell fate defects caused by Pdgfrb activating mutation. Development. 2021 12 01; 148(23). PMID: 34738614.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Woods JP, Srinivasan RS, Olson LE. Sweet Dre-ams about intersectional genetics. Cell Stem Cell. 2021 06 03; 28(6):989-990. PMID: 34087159.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors. Matrix Biol. 2021 03; 97:40-57. PMID: 33454424; PMCID: PMC8039968.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Sun C, Sakashita H, Kim J, Tang Z, Upchurch GM, Yao L, Berry WL, Griffin TM, Olson LE. Mosaic Mutant Analysis Identifies PDGFRa/PDGFRß as Negative Regulators of Adipogenesis. Cell Stem Cell. 2020 05 07; 26(5):707-721.e5. PMID: 32229310.
      Citations: 27     Fields:    Translation:AnimalsCells
    10. Medley SC, Rathnakar BH, Georgescu C, Wren JD, Olson LE. Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair. Wound Repair Regen. 2020 07; 28(4):448-459. PMID: 32175700.
      Citations: 10     Fields:    Translation:AnimalsCells
    11. Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Dysregulated mesenchymal PDGFR-ß drives kidney fibrosis. EMBO Mol Med. 2020 03 06; 12(3):e11021. PMID: 31943786.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    12. Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/ß-Catenin Signaling. Cell Rep. 2018 10 16; 25(3):571-584.e5. PMID: 30332639.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    13. He C, Medley SC, Kim J, Sun C, Kwon HR, Sakashita H, Pincu Y, Yao L, Eppard D, Dai B, Berry WL, Griffin TM, Olson LE. STAT1 modulates tissue wasting or overgrowth downstream from PDGFRß. Genes Dev. 2017 08 15; 31(16):1666-1678. PMID: 28924035.
      Citations: 20     Fields:    Translation:AnimalsCells
    14. Sun C, Berry WL, Olson LE. PDGFRa controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017 01 01; 144(1):83-94. PMID: 28049691.
      Citations: 46     Fields:    Translation:AnimalsCells
    15. He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 03; 91(3):642-657. PMID: 27914705.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    16. Dozmorov MG, Adrianto I, Giles CB, Glass E, Glenn SB, Montgomery C, Sivils KL, Olson LE, Iwayama T, Freeman WM, Lessard CJ, Wren JD. Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data. BMC Bioinformatics. 2015; 16 Suppl 13:S10. PMID: 26423047.
      Citations: 14     Fields:    Translation:Humans
    17. He C, Medley SC, Hu T, Hinsdale ME, Lupu F, Virmani R, Olson LE. PDGFRß signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun. 2015 Jul 17; 6:7770. PMID: 26183159.
      Citations: 78     Fields:    Translation:AnimalsCells
    18. Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE. PDGFRa signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 2015 Jun 01; 29(11):1106-19. PMID: 26019175.
      Citations: 88     Fields:    Translation:AnimalsCells
    19. Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH. Double minute amplification of mutant PDGF receptor a in a mouse glioma model. Sci Rep. 2015 Feb 16; 5:8468. PMID: 25683249.
      Citations: 9     Fields:    Translation:AnimalsCells
    20. Iwayama T, Olson LE. Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities. Curr Rheumatol Rep. 2013 Feb; 15(2):304. PMID: 23307576.
      Citations: 33     Fields:    Translation:HumansAnimals
    21. Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial construction of an arterial wall. Dev Cell. 2012 Sep 11; 23(3):482-93. PMID: 22975322; PMCID: PMC3500096.
      Citations: 51     Fields:    Translation:AnimalsCells
    22. Sun Y, Teng I, Huo R, Rosenfeld MG, Olson LE, Li X, Li X. Asymmetric requirement of surface epithelial ß-catenin during the upper and lower jaw development. Dev Dyn. 2012 Apr; 241(4):663-74. PMID: 22354888.
      Citations: 10     Fields:    Translation:AnimalsCells
    23. Olson LE, Soriano P. PDGFRß signaling regulates mural cell plasticity and inhibits fat development. Dev Cell. 2011 Jun 14; 20(6):815-26. PMID: 21664579.
      Citations: 112     Fields:    Translation:AnimalsCells
    24. Olson LE, Soriano P. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell. 2009 Feb; 16(2):303-13. PMID: 19217431.
      Citations: 136     Fields:    Translation:AnimalsCells
    25. Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG. Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell. 2006 May 05; 125(3):593-605. PMID: 16678101.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    26. Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3708-13. PMID: 15728386; PMCID: PMC553323.
      Citations: 25     Fields:    Translation:Animals
    27. Toyo-oka K, Hirotsune S, Gambello MJ, Zhou ZQ, Olson L, Rosenfeld MG, Eisenman R, Hurlin P, Wynshaw-Boris A. Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004 May 15; 13(10):1057-67. PMID: 15028671.
      Citations: 26     Fields:    Translation:Animals
    28. Olson LE, Dasen JS, Ju BG, Tollkuhn J, Rosenfeld MG. Paired-like repression/activation in pituitary development. Recent Prog Horm Res. 2003; 58:249-61. PMID: 12795422.
      Citations: 3     Fields:    Translation:HumansAnimals
    29. Olson LE, Rosenfeld MG. Perspective: genetic and genomic approaches in elucidating mechanisms of pituitary development. Endocrinology. 2002 Jun; 143(6):2007-11. PMID: 12021162.
      Citations: 2     Fields:    Translation:HumansAnimals
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