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Susan Kovats

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
Addressn/a
825 N.E. 13th Street
Oklahoma City OK 73104
Phone405/271-8583
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    Collapse Research 
    Collapse research activities and funding
    R01EB025596     (KOVATS, SUSAN)Sep 20, 2018 - Jun 30, 2022
    NIH
    A 3D human tissue-engineered lung model to study immune responses to Respiratory Syncytial Virus
    Role: Principal Investigator

    R01HL119501     (KOVATS, SUSAN)Sep 1, 2014 - Jul 31, 2019
    NIH
    IRF4-Mediated Regulation of Lung Dendritic Cells During Viral Infection
    Role: Principal Investigator

    R21AI092511     (KOVATS, SUSAN)Dec 1, 2010 - Nov 30, 2013
    NIH
    Regulation of dendritic cells by estrogen receptors during influenza infection
    Role: Principal Investigator

    R56AI083715     (KOVATS, SUSAN)Aug 24, 2010 - Jul 31, 2012
    NIH
    Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Role: Principal Investigator

    R21AI079616     (KOVATS, SUSAN)Aug 15, 2008 - Jul 31, 2011
    NIH
    Do estrogen receptors in B cells and DC mediate sex bias in murine lupus?
    Role: Principal Investigator

    R21AI063078     (KOVATS, SUSAN)Jul 1, 2005 - Jun 30, 2008
    NIH
    Estrogen Receptor Modulators and Dendritic Cell Function
    Role: Principal Investigator

    R01AI044922     (KOVATS, SUSAN)May 1, 1999 - Apr 30, 2005
    NIH
    REGULATION OF SELF ANTIGEN PRESENTATION BY MHC CLASS II
    Role: Principal Investigator

    F32AI008903     (KOVATS, SUSAN)Mar 29, 1993
    NIH
    COMPARTMENTALIZATION IN PEPTIDE/HLA CLASS II INTERACTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Isola JVV, Oca?as SR, Hubbart CR, Ko S, Mondal SA, Hense JD, Carter HNC, Schneider A, Kovats S, Alberola-Ila J, Freeman WM, Stout MB. A single-cell atlas of the aging mouse ovary. Nat Aging. 2024 Jan; 4(1):145-162. PMID: 38200272; PMCID: PMC10798902.
      Citations: 1     Translation:HumansAnimalsCells
    2. Isola JVV, Oca?as SR, Hubbart CR, Ko S, Mondal SA, Hense JD, Carter HNC, Schneider A, Kovats S, Alberola-Ila J, Freeman WM, Stout MB. A single-cell atlas of the aging murine ovary. bioRxiv. 2023 Sep 06. PMID: 37162983; PMCID: PMC10168416.
      Citations:    
    3. Roe MM, Do T, Turner S, Jevitt AM, Chlebicz M, White K, Oomens AGP, Rankin S, Kovats S, Gappa-Fahlenkamp H. Blood myeloid cells differentiate to lung resident cells and respond to pathogen stimuli in a 3D human tissue-engineered lung model. Front Bioeng Biotechnol. 2023; 11:1212230. PMID: 37485324; PMCID: PMC10361305.
      Citations:    
    4. Schafer CM, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu ML, Johnson CF, Shah AV, Haskard DO, Buxton A, Willis E, Wheeler K, Turner S, Chlebicz M, Scott RP, Kovats S, Cleuren A, Birdsey GM, Randi AM, Griffin CT. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge. Arterioscler Thromb Vasc Biol. 2023 08; 43(8):1412-1428. PMID: 37317853; PMCID: PMC10364964.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Miller RAJ, Williams AP, Kovats S. Sex chromosome complement and sex steroid signaling underlie sex differences in immunity to respiratory virus infection. Front Pharmacol. 2023; 14:1150282. PMID: 37063266; PMCID: PMC10097973.
      Citations: 2     
    6. Zyla-Jackson K, Walton DA, Plafker KS, Kovats S, Georgescu C, Brush RS, Tytanic M, Agbaga MP, Plafker SM. Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis. Front Neurol. 2023; 14:1113954. PMID: 36937529; PMCID: PMC10017782.
      Citations: 1     
    7. Turner S, Raisley B, Roach K, Baja?a S, Munroe ME, James JA, Coggeshall KM, Kovats S. Gram-Positive Bacteria Cell Wall Peptidoglycan Polymers Activate Human Dendritic Cells to Produce IL-23 and IL-1? and Promote TH17 Cell Differentiation. Microorganisms. 2023 Jan 10; 11(1). PMID: 36677464.
      Citations: 4     
    8. Gunay G, Hamsici S, Lang GA, Lang ML, Kovats S, Acar H. Peptide Aggregation Induced Immunogenic Rupture (PAIIR). Adv Sci (Weinh). 2022 07; 9(21):e2105868. PMID: 35599386.
      Citations: 3     Fields:    Translation:HumansAnimals
    9. Wu W, Tian L, Zhang W, Booth JL, Ainsua-Enrich E, Kovats S, Brown BR, Metcalf JP. Long-term cigarette smoke exposure dysregulates pulmonary T cell response and IFN-? protection to influenza virus in mouse. Respir Res. 2021 Apr 20; 22(1):112. PMID: 33879121.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Jørgensen TN, Kovats S, Lotter H. Editorial: Effects of Androgens on Immunity to Self and Foreign. Front Immunol. 2020; 11:630066. PMID: 33408721.
      Citations:    Fields:    Translation:Humans
    11. Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Front Immunol. 2020; 11:577718. PMID: 33391258.
      Citations:    Fields:    Translation:AnimalsCells
    12. Ainsua-Enrich E, Hatipoglu I, Kadel S, Turner S, Paul J, Singh S, Bagavant H, Kovats S. IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection. Mucosal Immunol. 2019 07; 12(4):1025-1037. PMID: 31089186.
      Citations: 19     Fields:    Translation:AnimalsCells
    13. Pan Z, Dumas EK, Lawrence C, Pate L, Longobardi S, Wang X, James JA, Kovats S, Farris AD. Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling. Int J Mol Sci. 2019 Mar 07; 20(5). PMID: 30866434.
      Citations: 4     Fields:    Translation:HumansCells
    14. Kadel S, Kovats S. Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection. Front Immunol. 2018; 9:1653. PMID: 30079065.
      Citations: 89     Fields:    
    15. Kadel S, Ainsua-Enrich E, Hatipoglu I, Turner S, Singh S, Khan S, Kovats S. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. Immunohorizons. 2018 Feb; 2(2):74-86. PMID: 29568816.
      Citations: 40     Fields:    
    16. Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF, Nordmark G, Lessard CJ, Sivils KL. Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun; 13(6):e1006820. PMID: 28640813.
      Citations: 39     Fields:    Translation:HumansCells
    17. Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol. 2017 06; 69(6):1221-1232. PMID: 28141918.
      Citations: 41     Fields:    Translation:AnimalsCells
    18. Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP. Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets. J Immunol. 2017 02 01; 198(3):1183-1201. PMID: 28031342.
      Citations: 31     Fields:    Translation:HumansCells
    19. Shapiro VS, Kovats S, Parent MA, Gaffen SL, Hedrick CC, Jain P, Denzin LK, Raghavan M, Stephens R. Update on Gender Equity in Immunology, 2001 to 2016. J Immunol. 2016 11 15; 197(10):3751-3753. PMID: 27798172.
      Citations: 1     Fields:    Translation:Humans
    20. Kovats S, Turner S, Simmons A, Powe T, Chakravarty E, Alberola-Ila J. West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells. Clin Exp Immunol. 2016 Nov; 186(2):214-226. PMID: 27513522.
      Citations: 12     Fields:    Translation:HumansCells
    21. Bajaña S, Turner S, Paul J, Ainsua-Enrich E, Kovats S. IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells. J Immunol. 2016 Feb 15; 196(4):1666-77. PMID: 26746189.
      Citations: 51     Fields:    Translation:AnimalsCells
    22. Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 2015 Apr; 294(2):63-9. PMID: 25682174.
      Citations: 411     Fields:    Translation:HumansAnimalsCells
    23. Carreras E, Kovats S. Girl power: estrogen promotes HSC self-renewal. Cell Stem Cell. 2014 Feb 06; 14(2):137-8. PMID: 24506879.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Hu T, Wang H, Simmons A, Bajaña S, Zhao Y, Kovats S, Sun XH, Alberola-Ila J. Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets. J Immunol. 2013 Nov 15; 191(10):5065-73. PMID: 24123679.
      Citations: 20     Fields:    Translation:AnimalsCells
    25. Bajaña S, Roach K, Turner S, Paul J, Kovats S. IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol. 2012 Oct 01; 189(7):3368-77. PMID: 22933627.
      Citations: 88     Fields:    Translation:AnimalsCells
    26. Kovats S. Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity. Horm Behav. 2012 Aug; 62(3):254-62. PMID: 22561458.
      Citations: 63     Fields:    Translation:AnimalsCells
    27. Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol. 2012 May; 91(5):783-90. PMID: 22331103.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Carreras E, Turner S, Frank MB, Knowlton N, Osban J, Centola M, Park CG, Simmons A, Alberola-Ila J, Kovats S. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood. 2010 Jan 14; 115(2):238-46. PMID: 19880499.
      Citations: 44     Fields:    Translation:AnimalsCells
    29. Malhotra S, Kovats S, Zhang W, Coggeshall KM. Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem. 2009 Dec 25; 284(52):36202-36212. PMID: 19858206.
      Citations: 19     Fields:    Translation:AnimalsCells
    30. Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, Neas B, Mathian A, Koss MN, Stohl W, Kovats S, Jacob CO. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol. 2009 Nov 01; 183(9):6021-9. PMID: 19812195.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    31. Malhotra S, Kovats S, Zhang W, Coggeshall KM. B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem. 2009 Sep 04; 284(36):24088-97. PMID: 19586920.
      Citations: 33     Fields:    Translation:AnimalsCells
    32. Sawalha AH, Kovats S. Dehydroepiandrosterone in systemic lupus erythematosus. Curr Rheumatol Rep. 2008 Aug; 10(4):286-91. PMID: 18662508.
      Citations: 17     Fields:    Translation:HumansAnimals
    33. Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton DR, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol. 2008 Jul; 82(14):7078-88. PMID: 18480436.
      Citations: 75     Fields:    Translation:AnimalsCells
    34. Kovats S, Carreras E. Regulation of dendritic cell differentiation and function by estrogen receptor ligands. Cell Immunol. 2008 Mar-Apr; 252(1-2):81-90. PMID: 18279845.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    35. Carreras E, Turner S, Paharkova-Vatchkova V, Mao A, Dascher C, Kovats S. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol. 2008 Jan 15; 180(2):727-38. PMID: 18178810.
      Citations: 55     Fields:    Translation:AnimalsCells
    36. Rinderknecht CH, Belmares MP, Catanzarite TL, Bankovich AJ, Holmes TH, Garcia KC, Nanda NK, Busch R, Kovats S, Mellins ED. Posttranslational regulation of I-Ed by affinity for CLIP. J Immunol. 2007 Nov 01; 179(9):5907-15. PMID: 17947664.
      Citations: 8     Fields:    Translation:AnimalsCells
    37. Tran CN, Davis MJ, Tesmer LA, Endres JL, Motyl CD, Smuda C, Somers EC, Chung KC, Urquhart AG, Lundy SK, Kovats S, Fox DA. Presentation of arthritogenic peptide to antigen-specific T cells by fibroblast-like synoviocytes. Arthritis Rheum. 2007 May; 56(5):1497-506. PMID: 17469112.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    38. Mao A, Paharkova-Vatchkova V, Hardy J, Miller MM, Kovats S. Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells. J Immunol. 2005 Oct 15; 175(8):5146-51. PMID: 16210618.
      Citations: 34     Fields:    Translation:AnimalsCells
    39. Nalbandian G, Paharkova-Vatchkova V, Mao A, Nale S, Kovats S. The selective estrogen receptor modulators, tamoxifen and raloxifene, impair dendritic cell differentiation and activation. J Immunol. 2005 Aug 15; 175(4):2666-75. PMID: 16081843.
      Citations: 39     Fields:    Translation:AnimalsCells
    40. Nalbandian G, Kovats S. Understanding sex biases in immunity: effects of estrogen on the differentiation and function of antigen-presenting cells. Immunol Res. 2005; 31(2):91-106. PMID: 15778508.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    41. Paharkova-Vatchkova V, Maldonado R, Kovats S. Estrogen preferentially promotes the differentiation of CD11c+ CD11b(intermediate) dendritic cells from bone marrow precursors. J Immunol. 2004 Feb 01; 172(3):1426-36. PMID: 14734718.
      Citations: 89     Fields:    Translation:AnimalsCells
    42. Tsark EC, Wang W, Teng YC, Arkfeld D, Dodge GR, Kovats S. Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol. 2002 Dec 01; 169(11):6625-33. PMID: 12444176.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    43. Dongre AR, Kovats S, deRoos P, McCormack AL, Nakagawa T, Paharkova-Vatchkova V, Eng J, Caldwell H, Yates JR, Rudensky AY. In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. Eur J Immunol. 2001 May; 31(5):1485-94. PMID: 11465105.
      Citations: 49     Fields:    Translation:AnimalsCells
    44. Kovats S, Grubin CE, Eastman S, deRoos P, Dongre A, Van Kaer L, Rudensky AY. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med. 1998 Jan 19; 187(2):245-51. PMID: 9432982.
      Citations: 12     Fields:    Translation:AnimalsCells
    45. Ramachandra L, Kovats S, Eastman S, Rudensky AY. Variation in HLA-DM expression influences conversion of MHC class II alpha beta:class II-associated invariant chain peptide complexes to mature peptide-bound class II alpha beta dimers in a normal B cell line. J Immunol. 1996 Mar 15; 156(6):2196 - 2204. PMID: 8690909.
      Citations: 10     Fields:    Translation:HumansCells
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