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Mark L Lang

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBMSB 1021
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    U19AI174994     (LANG, MARK L)Jul 25, 2023 - Jun 30, 2028
    Advancing a second generation C. difficile vaccine
    Role: Principal Investigator

    R01AI134719     (LANG, MARK L)Nov 6, 2017 - Oct 31, 2023
    Activation of semi-invariant and diverse NKT cells with an adjuvant combination
    Role: Principal Investigator

    R21AI125708     (LANG, MARK L)Jul 1, 2016 - Jun 30, 2019
    Re-directing B cell responses to carbohydrate antigens
    Role: Principal Investigator

    R01AI078993     (LANG, MARK L)Feb 15, 2009 - Aug 3, 2014
    Regulation of humoral immunity by NKT cells
    Role: Principal Investigator

    R56AI078993     (LANG, MARK L)Jul 1, 2008 - Jul 31, 2016
    Regulation of humoral immunity by NKT cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ray AL, Saunders AS, Nofchissey RA, Reidy MA, Kamal M, Lerner MR, Fung KM, Lang ML, Hanson JA, Guo S, Urdaneta-Perez MG, Lewis SE, Cloyde M, Morris KT. Granulocyte colony stimulating factor is a novel mediator of T cell suppression and an immunotherapeutic target for women with colon cancer. Clin Cancer Res. 2023 Mar 23. PMID: 36951682.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gunay G, Hamsici S, Lang GA, Lang ML, Kovats S, Acar H. Peptide Aggregation Induced Immunogenic Rupture (PAIIR). Adv Sci (Weinh). 2022 07; 9(21):e2105868. PMID: 35599386.
      Citations: 3     Fields:    Translation:HumansAnimals
    3. Ofman G, Lang ML. Reply To Chang and Liaw. J Infect Dis. 2022 04 19; 225(8):1494-1495. PMID: 34929040.
      Citations:    Fields:    
    4. Larcade R, DeShea L, Lang GA, Caballero MT, Ferretti A, Beasley WH, Tipple TE, Vain N, Prudent L, Lang ML, Polack FP, Ofman G. Maternal-Fetal Immunologic Response to SARS-CoV-2 Infection in a Symptomatic Vulnerable Population: A Prospective Cohort. J Infect Dis. 2022 03 02; 225(5):800-809. PMID: 34865064.
      Citations: 3     Fields:    Translation:HumansCells
    5. Song CJ, Li Z, Ahmed UKB, Bland SJ, Yashchenko A, Liu S, Aloria EJ, Lever JM, Gonzalez NM, Bickel MA, Giles CB, Georgescu C, Wren JD, Lang ML, Benveniste EN, Harrington LE, Tsiokas L, George JF, Jones KL, Crossman DK, Agarwal A, Mrug M, Yoder BK, Hopp K, Zimmerman KA. A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice. J Am Soc Nephrol. 2022 04; 33(4):747-768. PMID: 35110364.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Lang GA, Norman K, Amadou Amani S, Shadid TM, Ballard JD, Lang ML. Use of a Clostridioides difficile Murine Immunization and Challenge Model to Evaluate Single and Combination Vaccine Adjuvants Consisting of Alum and NKT Cell-Activating Ligands. Front Immunol. 2021; 12:818734. PMID: 35095921.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    7. Liu K, Hoover AR, Krawic JR, DeVette CI, Sun XH, Hildebrand WH, Lang ML, Axtell RC, Chen WR. Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival. Theranostics. 2022; 12(2):639-656. PMID: 34976205.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Lang GA, Shrestha B, Amadou Amani S, Shadid TM, Ballard JD, Lang ML. a-Galactosylceramide-Reactive NKT Cells Increase IgG1 Class Switch against a Clostridioides difficile Polysaccharide Antigen and Enhance Immunity against a Live Pathogen Challenge. Infect Immun. 2021 10 15; 89(11):e0043821. PMID: 34424751.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    9. Amadou Amani S, Lang GA, Ballard JD, Lang ML. The Murine Neonatal Fc Receptor Is Required for Transport of Immunization-Induced C. difficile-Specific IgG to the Gut and Protection against Disease but Does Not Affect Disease Susceptibility. Infect Immun. 2021 09 16; 89(10):e0027421. PMID: 34097471.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Amadou Amani S, Lang ML. Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses. Front Immunol. 2020; 11:565648. PMID: 33042146.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Shah HB, Smith K, Scott EJ, Larabee JL, James JA, Ballard JD, Lang ML. Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies. JCI Insight. 2020 08 20; 5(16). PMID: 32663199.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Amadou Amani S, Shadid T, Ballard JD, Lang ML. Clostridioides difficile Infection Induces an Inferior IgG Response to That Induced by Immunization and Is Associated with a Lack of T Follicular Helper Cell and Memory B Cell Expansion. Infect Immun. 2020 02 20; 88(3). PMID: 31871095.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    13. Bland SJ, Larabee JL, Shadid TM, Lang ML, Ballard JD. Deletion of a 19-Amino-Acid Region in Clostridioides difficile TcdB2 Results in Spontaneous Autoprocessing and Reduced Cell Binding and Provides a Nontoxic Immunogen for Vaccination. Infect Immun. 2019 08; 87(8). PMID: 31138612.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Lang GA, Amadou Amani S, Quinn JL, Axtell RC, Lang ML. Immunization-Expanded NKT Follicular Helper Cells Drive IgG1 Isotype Switch against an Exogenous T-Independent Polysaccharide but Do Not Promote Recall Responses. Immunohorizons. 2019 03; 3(3):88-93. PMID: 31342012.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML. Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. Front Immunol. 2018; 9:3064. PMID: 30697210.
      Citations: 8     Fields:    Translation:HumansCells
    16. Zhou F, Yang J, Zhang Y, Liu M, Lang ML, Li M, Chen WR. Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine. Clin Cancer Res. 2018 11 01; 24(21):5335-5346. PMID: 30068705.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    17. Lang ML. The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens. Front Immunol. 2018; 9:305. PMID: 29520280.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    18. Lang ML, Shrestha B. Adaptive immune constraints on C. difficile vaccination. Expert Rev Vaccines. 2017 11; 16(11):1053-1055. PMID: 28899198.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    19. Lang ML. CD1d-dependent CLL progression? Blood. 2017 06 29; 129(26):3398-3399. PMID: 28663222.
      Citations:    Fields:    Translation:Humans
    20. Janakiram NB, Mohammed A, Bryant T, Ritchie R, Stratton N, Jackson L, Lightfoot S, Benbrook DM, Asch AS, Lang ML, Rao CV. Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. Immunology. 2017 09; 152(1):36-51. PMID: 28419443.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    21. Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. 2017 02; 101(2):567-576. PMID: 27566831.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Richer MJ, Lang ML, Butler NS. T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. J Immunol. 2016 08 15; 197(4):1009-15. PMID: 27496973.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    23. Devera TS, Lang GA, Lanis JM, Rampuria P, Gilmore CL, James JA, Ballard JD, Lang ML. Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. Infect Immun. 2016 01; 84(1):194-204. PMID: 26502913.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    24. Devera TS, Prusator DK, Joshi SK, Ballard JD, Lang ML. Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge. Toxins (Basel). 2015 Jun 25; 7(7):2371-84. PMID: 26120785.
      Citations: 1     Fields:    Translation:AnimalsCells
    25. Rampuria P, Lang ML. CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation. Int Immunol. 2015 May; 27(5):253-63. PMID: 25710490.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Lang ML. The importance of B cell CD1d expression for humoral immunity. Expert Rev Vaccines. 2014 Nov; 13(11):1275-8. PMID: 24946838.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    27. Janakiram NB, Mohammed A, Bryant T, Brewer M, Biddick L, Lightfoot S, Lang ML, Rao CV. Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein. Mol Carcinog. 2015 Oct; 54(10):986-98. PMID: 24797894.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. Shah HB, Joshi SK, Rampuria P, Devera TS, Lang GA, Stohl W, Lang ML. BAFF- and APRIL-dependent maintenance of antibody titers after immunization with T-dependent antigen and CD1d-binding ligand. J Immunol. 2013 Aug 01; 191(3):1154-63. PMID: 23797666.
      Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Joshi SK, Lang ML. Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function. Int Immunopharmacol. 2013 Oct; 17(2):260-6. PMID: 23800654.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    30. Shah HB, Devera TS, Rampuria P, Lang GA, Lang ML. Type II NKT cells facilitate Alum-sensing and humoral immunity. J Leukoc Biol. 2012 Oct; 92(4):883-93. PMID: 22798686.
      Citations: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol. 2012 May; 91(5):783-90. PMID: 22331103.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Shah HB, Joshi SK, Lang ML. CD40L-null NKT cells provide B cell help for specific antibody responses. Vaccine. 2011 Nov 15; 29(49):9132-6. PMID: 21959330.
      Citations: 10     Fields:    Translation:AnimalsCells
    33. Devera TS, Joshi SK, Aye LM, Lang GA, Ballard JD, Lang ML. Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFN?. PLoS One. 2011; 6(8):e23817. PMID: 21858226.
      Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    34. Lang GA, Johnson AM, Devera TS, Joshi SK, Lang ML. Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory. Int Immunol. 2011 Apr; 23(4):251-60. PMID: 21398691.
      Citations: 10     Fields:    Translation:AnimalsCells
    35. Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010 Aug; 78(8):3484-92. PMID: 20498261.
      Citations: 12     Fields:    Translation:AnimalsCells
    36. Devera TS, Aye LM, Lang GA, Joshi SK, Ballard JD, Lang ML. CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. Infect Immun. 2010 Apr; 78(4):1610-7. PMID: 20123711.
      Citations: 21     Fields:    Translation:AnimalsCells
    37. Joshi SK, Lang GA, Larabee JL, Devera TS, Aye LM, Shah HB, Ballard JD, Lang ML. Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. PLoS Pathog. 2009 Sep; 5(9):e1000588. PMID: 19779559.
      Citations: 23     Fields:    Translation:AnimalsCells
    38. Lang ML. How do natural killer T cells help B cells? Expert Rev Vaccines. 2009 Aug; 8(8):1109-21. PMID: 19627191.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    39. Devera TS, Shah HB, Lang GA, Lang ML. Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers. Eur J Immunol. 2008 Apr; 38(4):1001-11. PMID: 18350547.
      Citations: 34     Fields:    Translation:AnimalsCells
    40. Lang GA, Devera TS, Lang ML. Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production. Blood. 2008 Feb 15; 111(4):2158-62. PMID: 18077787.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    41. Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204. PMID: 17980030.
      Citations: 10     Fields:    Translation:Animals
    42. Bessette K, Lang ML, Fava RA, Grundy M, Heinen J, Horne L, Spolski R, Al-Shami A, Morse HC, Leonard WJ, Kelly JA. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood. 2008 Jan 01; 111(1):344-50. PMID: 17890450.
      Citations: 6     Fields:    Translation:AnimalsCells
    43. Lang GA, Exley MA, Lang ML. The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. Immunology. 2006 Sep; 119(1):116-25. PMID: 16792697.
      Citations: 44     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Pleass RJ, Lang ML, Kerr MA, Woof JM. IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE. Mol Immunol. 2007 Feb; 44(6):1401-8. PMID: 16777227.
      Citations: 13     Fields:    Translation:HumansCells
    45. Lang GA, Lang ML. Protein kinase Balpha is required for vesicle trafficking and class II presentation of IgA Fc receptor (CD89)-targeted antigen. J Immunol. 2006 Apr 01; 176(7):3987-94. PMID: 16547233.
      Citations: 3     Fields:    Translation:Cells
    46. Lang ML, Glatman-Freedman A. Do CD1-restricted T cells contribute to antibody-mediated immunity against Mycobacterium tuberculosis? Infect Immun. 2006 Feb; 74(2):803-9. PMID: 16428722.
      Citations: 8     Fields:    Translation:HumansCells
    47. Lang GA, Illarionov PA, Glatman-Freedman A, Besra GS, Lang ML. BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments. Int Immunol. 2005 Jul; 17(7):899-908. PMID: 15967785.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Chen YW, Lang ML, Wade WF. Protein kinase C-alpha and -delta are required for FcalphaR (CD89) trafficking to MHC class II compartments and FcalphaR-mediated antigen presentation. Traffic. 2004 Aug; 5(8):577-94. PMID: 15260828.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    49. Lang GA, Maltsev SD, Besra GS, Lang ML. Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts. Immunology. 2004 Jul; 112(3):386-96. PMID: 15196206.
      Citations: 26     Fields:    Translation:AnimalsCells
    50. Lang ML, Chen YW, Shen L, Gao H, Lang GA, Wade TK, Wade WF. IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts. Biochem J. 2002 Jun 01; 364(Pt 2):517-25. PMID: 12023895.
      Citations: 17     Fields:    Translation:Cells
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