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Mark L Lang

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBMSB 1021
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    R56AI078993     (LANG, MARK L)Jul 1, 2008 - Jul 31, 2016
    Regulation of humoral immunity by NKT cells
    Role: Principal Investigator

    R01AI078993     (LANG, MARK L)Feb 15, 2009 - Aug 3, 2014
    Regulation of humoral immunity by NKT cells
    Role: Principal Investigator

    R21AI125708     (LANG, MARK L)Jul 1, 2016 - Jun 30, 2019
    Re-directing B cell responses to carbohydrate antigens
    Role: Principal Investigator

    R01AI134719     (LANG, MARK L)Nov 6, 2017 - Oct 31, 2022
    Activation of semi-invariant and diverse NKT cells with an adjuvant combination
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amadou Amani S, Lang GA, Ballard JD, Lang ML. The murine neonatal Fc receptor is required for transport of immunization-induced C. difficile-specific IgG to the gut and protection against disease but does not affect disease susceptibility. Infect Immun. 2021 Jun 07; IAI0027421. PMID: 34097471.
    2. Amadou Amani S, Lang ML. Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses. Front Immunol. 2020; 11:565648. PMID: 33042146.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Shah HB, Smith K, Scott EJ, Larabee JL, James JA, Ballard JD, Lang ML. Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies. JCI Insight. 2020 08 20; 5(16). PMID: 32663199.
      Citations: 1     Fields:    
    4. Amadou Amani S, Shadid T, Ballard JD, Lang ML. Clostridioides difficile Infection Induces an Inferior IgG Response to That Induced by Immunization and Is Associated with a Lack of T Follicular Helper Cell and Memory B Cell Expansion. Infect Immun. 2020 02 20; 88(3). PMID: 31871095.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    5. Bland SJ, Larabee JL, Shadid TM, Lang ML, Ballard JD. Deletion of a 19-Amino-Acid Region in Clostridioides difficile TcdB2 Results in Spontaneous Autoprocessing and Reduced Cell Binding and Provides a Nontoxic Immunogen for Vaccination. Infect Immun. 2019 08; 87(8). PMID: 31138612.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    6. Lang GA, Amadou Amani S, Quinn JL, Axtell RC, Lang ML. Immunization-Expanded NKT Follicular Helper Cells Drive IgG1 Isotype Switch against an Exogenous T-Independent Polysaccharide but Do Not Promote Recall Responses. Immunohorizons. 2019 03; 3(3):88-93. PMID: 31342012.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    7. Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML. Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. Front Immunol. 2018; 9:3064. PMID: 30697210.
      Citations: 4     Fields:    Translation:HumansCells
    8. Zhou F, Yang J, Zhang Y, Liu M, Lang ML, Li M, Chen WR. Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine. Clin Cancer Res. 2018 11 01; 24(21):5335-5346. PMID: 30068705.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    9. Lang ML. The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens. Front Immunol. 2018; 9:305. PMID: 29520280.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Lang ML, Shrestha B. Adaptive immune constraints on C. difficile vaccination. Expert Rev Vaccines. 2017 11; 16(11):1053-1055. PMID: 28899198.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Lang ML. CD1d-dependent CLL progression? Blood. 2017 06 29; 129(26):3398-3399. PMID: 28663222.
      Citations:    Fields:    Translation:Humans
    12. Janakiram NB, Mohammed A, Bryant T, Ritchie R, Stratton N, Jackson L, Lightfoot S, Benbrook DM, Asch AS, Lang ML, Rao CV. Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. Immunology. 2017 09; 152(1):36-51. PMID: 28419443.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. 2017 02; 101(2):567-576. PMID: 27566831.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Richer MJ, Lang ML, Butler NS. T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. J Immunol. 2016 08 15; 197(4):1009-15. PMID: 27496973.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    15. Devera TS, Lang GA, Lanis JM, Rampuria P, Gilmore CL, James JA, Ballard JD, Lang ML. Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. Infect Immun. 2016 01; 84(1):194-204. PMID: 26502913.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Devera TS, Prusator DK, Joshi SK, Ballard JD, Lang ML. Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge. Toxins (Basel). 2015 Jun 25; 7(7):2371-84. PMID: 26120785.
      Citations: 1     Fields:    Translation:AnimalsCells
    17. Rampuria P, Lang ML. CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation. Int Immunol. 2015 May; 27(5):253-63. PMID: 25710490.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Lang ML. The importance of B cell CD1d expression for humoral immunity. Expert Rev Vaccines. 2014 Nov; 13(11):1275-8. PMID: 24946838.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Janakiram NB, Mohammed A, Bryant T, Brewer M, Biddick L, Lightfoot S, Lang ML, Rao CV. Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein. Mol Carcinog. 2015 Oct; 54(10):986-98. PMID: 24797894.
      Citations: 8     Fields:    Translation:AnimalsCells
    20. Shah HB, Joshi SK, Rampuria P, Devera TS, Lang GA, Stohl W, Lang ML. BAFF- and APRIL-dependent maintenance of antibody titers after immunization with T-dependent antigen and CD1d-binding ligand. J Immunol. 2013 Aug 01; 191(3):1154-63. PMID: 23797666.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Joshi SK, Lang ML. Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function. Int Immunopharmacol. 2013 Oct; 17(2):260-6. PMID: 23800654.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Shah HB, Devera TS, Rampuria P, Lang GA, Lang ML. Type II NKT cells facilitate Alum-sensing and humoral immunity. J Leukoc Biol. 2012 Oct; 92(4):883-93. PMID: 22798686.
      Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol. 2012 May; 91(5):783-90. PMID: 22331103.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    24. Shah HB, Joshi SK, Lang ML. CD40L-null NKT cells provide B cell help for specific antibody responses. Vaccine. 2011 Nov 15; 29(49):9132-6. PMID: 21959330.
      Citations: 7     Fields:    Translation:AnimalsCells
    25. Devera TS, Joshi SK, Aye LM, Lang GA, Ballard JD, Lang ML. Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFN?. PLoS One. 2011; 6(8):e23817. PMID: 21858226.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Lang GA, Johnson AM, Devera TS, Joshi SK, Lang ML. Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory. Int Immunol. 2011 Apr; 23(4):251-60. PMID: 21398691.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010 Aug; 78(8):3484-92. PMID: 20498261.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Devera TS, Aye LM, Lang GA, Joshi SK, Ballard JD, Lang ML. CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. Infect Immun. 2010 Apr; 78(4):1610-7. PMID: 20123711.
      Citations: 19     Fields:    Translation:AnimalsCells
    29. Joshi SK, Lang GA, Larabee JL, Devera TS, Aye LM, Shah HB, Ballard JD, Lang ML. Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. PLoS Pathog. 2009 Sep; 5(9):e1000588. PMID: 19779559.
      Citations: 23     Fields:    Translation:AnimalsCells
    30. Lang ML. How do natural killer T cells help B cells? Expert Rev Vaccines. 2009 Aug; 8(8):1109-21. PMID: 19627191.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    31. Devera TS, Shah HB, Lang GA, Lang ML. Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers. Eur J Immunol. 2008 Apr; 38(4):1001-11. PMID: 18350547.
      Citations: 31     Fields:    Translation:AnimalsCells
    32. Lang GA, Devera TS, Lang ML. Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production. Blood. 2008 Feb 15; 111(4):2158-62. PMID: 18077787.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    33. Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204. PMID: 17980030.
      Citations: 6     Fields:    Translation:Animals
    34. Bessette K, Lang ML, Fava RA, Grundy M, Heinen J, Horne L, Spolski R, Al-Shami A, Morse HC, Leonard WJ, Kelly JA. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood. 2008 Jan 01; 111(1):344-50. PMID: 17890450.
      Citations: 5     Fields:    Translation:AnimalsCells
    35. Lang GA, Exley MA, Lang ML. The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. Immunology. 2006 Sep; 119(1):116-25. PMID: 16792697.
      Citations: 42     Fields:    Translation:AnimalsCellsPHPublic Health
    36. Pleass RJ, Lang ML, Kerr MA, Woof JM. IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE. Mol Immunol. 2007 Feb; 44(6):1401-8. PMID: 16777227.
      Citations: 8     Fields:    Translation:HumansCells
    37. Lang GA, Lang ML. Protein kinase Balpha is required for vesicle trafficking and class II presentation of IgA Fc receptor (CD89)-targeted antigen. J Immunol. 2006 Apr 01; 176(7):3987-94. PMID: 16547233.
      Citations: 2     Fields:    Translation:Cells
    38. Lang ML, Glatman-Freedman A. Do CD1-restricted T cells contribute to antibody-mediated immunity against Mycobacterium tuberculosis? Infect Immun. 2006 Feb; 74(2):803-9. PMID: 16428722.
      Citations: 8     Fields:    Translation:HumansCells
    39. Lang GA, Illarionov PA, Glatman-Freedman A, Besra GS, Lang ML. BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments. Int Immunol. 2005 Jul; 17(7):899-908. PMID: 15967785.
      Citations: 9     Fields:    Translation:AnimalsCells
    40. Chen YW, Lang ML, Wade WF. Protein kinase C-alpha and -delta are required for FcalphaR (CD89) trafficking to MHC class II compartments and FcalphaR-mediated antigen presentation. Traffic. 2004 Aug; 5(8):577-94. PMID: 15260828.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    41. Lang GA, Maltsev SD, Besra GS, Lang ML. Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts. Immunology. 2004 Jul; 112(3):386-96. PMID: 15196206.
      Citations: 25     Fields:    Translation:AnimalsCells
    42. Lang ML, Chen YW, Shen L, Gao H, Lang GA, Wade TK, Wade WF. IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts. Biochem J. 2002 Jun 01; 364(Pt 2):517-25. PMID: 12023895.
      Citations: 17     Fields:    Translation:Cells
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