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William Edmund Sonntag

TitleProf,George L Cross Rsrch
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBMSB 860
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
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    P20GM125528     (SONNTAG, WILLIAM EDMUND)Feb 1, 2019 - Dec 31, 2024
    NIH
    CELLULAR AND MOLECULAR GEROSCIENCE CoBRE
    Role: Principal Investigator
    R01AG057424     (RICHARDSON, ARLAN G.)Sep 15, 2017 - May 31, 2022
    NIH
    TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
    Role: Co-Principal Investigator
    T32AG052363     (SONNTAG, WILLIAM EDMUND)May 1, 2017 - Apr 30, 2027
    NIH
    GEROSCIENCE TRAINING PROGRAM IN OKLAHOMA
    Role: Principal Investigator
    P30AG050911     (GALVAN, VERONICA)Jul 15, 2015 - May 31, 2025
    NIH
    Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
    Role: Principal Investigator
    R13AG041622     (HAROOTYAN, LINDA KROGH)Sep 30, 2011 - Mar 31, 2014
    NIH
    Biology of Aging Sessions at Meetings of The Gerontological Society of America
    Role: Co-Principal Investigator
    R01AG038747     (SONNTAG, WILLIAM EDMUND)Mar 1, 2011 - Feb 28, 2017
    NIH
    NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
    Role: Principal Investigator
    R01AG026607     (SONNTAG, WILLIAM EDMUND)Mar 1, 2007 - Jan 31, 2014
    NIH
    Cognitive Decline &Protein Expression Profiles in Aging
    Role: Principal Investigator
    R01NS056218     (SONNTAG, WILLIAM EDMUND)Jul 1, 2006 - Mar 31, 2019
    NIH
    Effects of Radiation on Brain Microvasculature and Cognition
    Role: Principal Investigator
    R01AG019392     (SONNTAG, WILLIAM EDMUND)May 1, 2001 - Apr 30, 2004
    NIH
    Growth Hormone, IGF-1 and Age-related Pathogenesis
    Role: Principal Investigator
    R01AG014768     (SONNTAG, WILLIAM EDMUND)May 1, 1998 - Apr 30, 2002
    NIH
    TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
    Role: Principal Investigator
    R01AA008536     (SONNTAG, WILLIAM EDMUND)Apr 1, 1990 - Mar 31, 1995
    NIH
    CHRONIC ETHANOL AND INSULIN-LIKE GROWTH FACTORS
    Role: Principal Investigator
    R01AG007752     (SONNTAG, WILLIAM EDMUND)Apr 1, 1988 - Mar 31, 1998
    NIH
    GROWTH HORMONE (GH) AND GH-DEPENDENT BIOMARKERS OF AGING
    Role: Principal Investigator
    R01AG005637     (SONNTAG, WILLIAM EDMUND)Sep 30, 1985 - Jun 30, 1989
    NIH
    REGULATION OF GROWTH HORMONE SECRETION IN AGING RATS
    Role: Principal Investigator
    R23AA006833     (SONNTAG, WILLIAM EDMUND)Sep 27, 1985 - Aug 31, 1988
    NIH
    CHRONIC ETHANOL, GROWTH HORMONE AND PROTEIN SYNTHESIS
    Role: Principal Investigator
    P01AG011370     (SONNTAG, WILLIAM EDMUND)Mar 31, 2013
    NIH
    Growth Hormone &IGF-1 in CNS and Cerebrovascular Aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mukli P, Pinto CB, Owens CD, Csipo T, Lipecz A, Szarvas Z, Peterfi A, Langley ACDCP, Hoffmeister J, Racz FS, Perry JW, Tarantini S, Ny?l-T?th ?, Sorond FA, Yang Y, James JA, Kirkpatrick AC, Prodan CI, Toth P, Galindo J, Gardner AW, Sonntag WE, Csiszar A, Ungvari Z, Yabluchanskiy A. Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction. Adv Sci (Weinh). 2023 Dec 28; e2303516. PMID: 38155460.
      Citations: 4     Fields:    Translation:Humans
    2. Williamson J, James SA, Mukli P, Yabluchanskiy A, Wu DH, Sonntag W, Alzheimer?s Disease Neuroimaging Initiative Consortium, Yang Y. Sex difference in brain functional connectivity of hippocampus in Alzheimer's disease. Geroscience. 2023 Sep 25. PMID: 37743414.
      Citations: 5     Fields:    Translation:Humans
    3. Gulej R, Ny?l-T?th ?, Ahire C, DelFavero J, Balasubramanian P, Kiss T, Tarantini S, Benyo Z, Pacher P, Csik B, Yabluchanskiy A, Mukli P, Kuan-Celarier A, Krizbai IA, Campisi J, Sonntag WE, Csiszar A, Ungvari Z. Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain. Geroscience. 2023 Aug 29. PMID: 37642933.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    4. Cassidy BR, Logan S, Farley JA, Owen DB, Sonntag WE, Drevets DA. Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection. Front Immunol. 2023; 14:1146690. PMID: 37143648; PMCID: PMC10151798.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Logan S, Baier MP, Owen DB, Peasari J, Jones KL, Ranjit R, Yarbrough HP, Masingale AM, Bhandari S, Rice HC, Kinter MT, Sonntag WE. Cognitive heterogeneity reveals molecular signatures of age-related impairment. PNAS Nexus. 2023 Apr; 2(4):pgad101. PMID: 37091543; PMCID: PMC10118303.
      Citations: 2     
    6. Li B, Yabluchanskiy A, Tarantini S, Allu SR, Sencan-Egilmez I, Leng J, Alfadhel MAH, Porter JE, Fu B, Ran C, Erdener SE, Boas DA, Vinogradov SA, Sonntag WE, Csiszar A, Ungvari Z, Sakad?ic S. Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter. Geroscience. 2023 Feb 16. PMID: 36792820.
      Citations: 6     Fields:    Translation:Animals
    7. Fazekas-Pongor V, P?terfi A, Major D, Szarvas Z, Fekete M, Tabak AG, Csiszar A, Sonntag WE, Austad SN, Ungvari ZI. Decreased lifespan in female "Munchkin" actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity. Geroscience. 2022 10; 44(5):2527-2539. PMID: 36334178; PMCID: PMC9768075.
      Citations: 3     Fields:    Translation:Humans
    8. Williamson J, Yabluchanskiy A, Mukli P, Wu DH, Sonntag W, Ciro C, Yang Y. Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment. Front Aging Neurosci. 2022; 14:959394. PMID: 36034134; PMCID: PMC9399646.
      Citations: 10     
    9. Cassidy BR, Sonntag WE, Leenen PJM, Drevets DA. Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155. Immun Ageing. 2022 May 25; 19(1):25. PMID: 35614490.
      Citations: 2     
    10. Miller LR, Tarantini S, Nyúl-Tóth Á, Johnston MP, Martin T, Bullen EC, Bickel MA, Sonntag WE, Yabluchanskiy A, Csiszar A, Ungvari ZI, Elliott MH, Conley SM. Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging. Front Aging Neurosci. 2022; 14:788296. PMID: 35356301.
      Citations: 18     
    11. Csipo T, Lipecz A, Owens C, Mukli P, Perry JW, Tarantini S, Balasubramanian P, Nyúl-Tóth Á, Yabluchanska V, Sorond FA, Kellawan JM, Purebl G, Sonntag WE, Csiszar A, Ungvari Z, Yabluchanskiy A. Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses. Sci Rep. 2021 10 25; 11(1):20994. PMID: 34697326.
      Citations: 12     Fields:    Translation:HumansCells
    12. Van Remmen H, Freeman WM, Miller BF, Kinter M, Wren JD, Chiao A, Towner RA, Snider TA, Sonntag WE, Richardson A. Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function. Geroscience. 2021 10; 43(5):2183-2203. PMID: 34606039.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Grieco F, Bernstein BJ, Biemans B, Bikovski L, Burnett CJ, Cushman JD, van Dam EA, Fry SA, Richmond-Hacham B, Homberg JR, Kas MJH, Kessels HW, Koopmans B, Krashes MJ, Krishnan V, Logan S, Loos M, McCann KE, Parduzi Q, Pick CG, Prevot TD, Riedel G, Robinson L, Sadighi M, Smit AB, Sonntag W, Roelofs RF, Tegelenbosch RAJ, Noldus LPJJ. Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives. Front Behav Neurosci. 2021; 15:735387. PMID: 34630052.
      Citations: 29     
    14. Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Mukli P, Balasubramanian P, Ungvari A, Toth P, Benyo Z, Sonntag WE, Ungvari Z, Csiszar A. Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype. Geroscience. 2021 10; 43(5):2387-2394. PMID: 34383203.
      Citations: 33     Fields:    Translation:AnimalsCells
    15. Mukli P, Csipo T, Lipecz A, Stylianou O, Racz FS, Owens CD, Perry JW, Tarantini S, Sorond FA, Kellawan JM, Purebl G, Yang Y, Sonntag WE, Csiszar A, Ungvari ZI, Yabluchanskiy A. Sleep deprivation alters task-related changes in functional connectivity of the frontal cortex: A near-infrared spectroscopy study. Brain Behav. 2021 08; 11(8):e02135. PMID: 34156165.
      Citations: 12     Fields:    Translation:Humans
    16. Tarantini S, Balasubramanian P, Yabluchanskiy A, Ashpole NM, Logan S, Kiss T, Ungvari A, Nyúl-Tóth Á, Schwartzman ML, Benyo Z, Sonntag WE, Csiszar A, Ungvari Z. IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging. Geroscience. 2021 04; 43(2):901-911. PMID: 33674953.
      Citations: 31     Fields:    Translation:AnimalsCells
    17. Cassidy BR, Zhang M, Sonntag WE, Drevets DA. Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion. J Neuroinflammation. 2020 Sep 02; 17(1):259. PMID: 32878636.
      Citations: 7     Fields:    Translation:AnimalsCells
    18. Parks EE, Logan S, Yeganeh A, Farley JA, Owen DB, Sonntag WE. Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. J Lipid Res. 2020 10; 61(10):1308-1319. PMID: 32669383.
      Citations: 9     Fields:    Translation:Animals
    19. Yabluchanskiy A, Tarantini S, Balasubramanian P, Kiss T, Csipo T, Fülöp GA, Lipecz A, Ahire C, DelFavero J, Nyul-Toth A, Sonntag WE, Schwartzman ML, Campisi J, Csiszar A, Ungvari Z. Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice. Geroscience. 2020 04; 42(2):409-428. PMID: 31960269.
      Citations: 56     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Logan S, Royce GH, Owen D, Farley J, Ranjo-Bishop M, Sonntag WE, Deepa SS. Accelerated decline in cognition in a mouse model of increased oxidative stress. Geroscience. 2019 10; 41(5):591-607. PMID: 31641924.
      Citations: 26     Fields:    Translation:Animals
    21. Farias Quipildor GE, Mao K, Hu Z, Novaj A, Cui MH, Gulinello M, Branch CA, Gubbi S, Patel K, Moellering DR, Tarantini S, Kiss T, Yabluchanskiy A, Ungvari Z, Sonntag WE, Huffman DM. Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice. Geroscience. 2019 04; 41(2):185-208. PMID: 31076997.
      Citations: 50     Fields:    Translation:AnimalsCells
    22. Csiszar A, Balasubramanian P, Tarantini S, Yabluchanskiy A, Zhang XA, Springo Z, Benbrook D, Sonntag WE, Ungvari Z. Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience. 2019 04; 41(2):209-227. PMID: 31037472.
      Citations: 10     Fields:    Translation:HumansAnimals
    23. Csipo T, Lipecz A, Fulop GA, Hand RA, Ngo BN, Dzialendzik M, Tarantini S, Balasubramanian P, Kiss T, Yabluchanska V, Silva-Palacios F, Courtney DL, Dasari TW, Sorond F, Sonntag WE, Csiszar A, Ungvari Z, Yabluchanskiy A. Age-related decline in peripheral vascular health predicts cognitive impairment. Geroscience. 2019 04; 41(2):125-136. PMID: 31030329.
      Citations: 49     Fields:    Translation:Humans
    24. Reagan AM, Gu X, Paudel S, Ashpole NM, Zalles M, Sonntag WE, Ungvari Z, Csiszar A, Otalora L, Freeman WM, Stout MB, Elliott MH. Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiol Aging. 2018 11; 71:1-12. PMID: 30059797.
      Citations: 8     Fields:    Translation:Animals
    25. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 06 14; 73(7):853-863. PMID: 29905772.
      Citations: 80     Fields:    Translation:Animals
    26. Logan S, Owen D, Chen S, Chen WJ, Ungvari Z, Farley J, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag WE. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. Geroscience. 2018 04; 40(2):123-137. PMID: 29687240.
      Citations: 23     Fields:    Translation:Animals
    27. Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z. Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice. Aging Cell. 2018 04; 17(2). PMID: 29405550.
      Citations: 97     Fields:    Translation:AnimalsCells
    28. Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes. Mol Metab. 2018 03; 9:141-155. PMID: 29398615.
      Citations: 77     Fields:    Translation:AnimalsCells
    29. Cho HJ, Lee WH, Hwang OMH, Sonntag WE, Lee YW. Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain. Int J Radiat Biol. 2017 11; 93(11):1257-1266. PMID: 28880721.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Gardner AW, Montgomery PS, Zhao YD, Ungvari Z, Csiszar A, Sonntag WE. Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease. Angiology. 2018 May; 69(5):416-423. PMID: 28835113.
      Citations: 5     Fields:    Translation:HumansCells
    31. Mangold CA, Wronowski B, Du M, Masser DR, Hadad N, Bixler GV, Brucklacher RM, Ford MM, Sonntag WE, Freeman WM. Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging. J Neuroinflammation. 2017 07 21; 14(1):141. PMID: 28732515.
      Citations: 93     Fields:    Translation:AnimalsCells
    32. Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE. IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience. 2017 04; 39(2):129-145. PMID: 28409331.
      Citations: 85     Fields:    Translation:Animals
    33. Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z. Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. 2017 06; 16(3):469-479. PMID: 28295976.
      Citations: 69     Fields:    Translation:AnimalsCells
    34. Gardner AW, Montgomery PS, Zhao YD, Silva-Palacios F, Ungvari Z, Csiszar A, Sonntag WE. Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease. J Vasc Surg. 2017 06; 65(6):1762-1768. PMID: 28259579.
      Citations: 12     Fields:    Translation:HumansCells
    35. Podlutsky A, Valcarcel-Ares MN, Yancey K, Podlutskaya V, Nagykaldi E, Gautam T, Miller RA, Sonntag WE, Csiszar A, Ungvari Z. The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer. Geroscience. 2017 04; 39(2):147-160. PMID: 28233247.
      Citations: 50     Fields:    Translation:AnimalsCells
    36. Hopiavuori BR, Agbaga MP, Brush RS, Sullivan MT, Sonntag WE, Anderson RE. Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint. J Lipid Res. 2017 04; 58(4):668-680. PMID: 28202633.
      Citations: 22     Fields:    Translation:Animals
    37. Sonntag WE, Ungvari Z. GeroScience: understanding the interaction of processes of aging and chronic diseases. Age (Dordr). 2016 12; 38(5-6):377-378. PMID: 27924421.
      Citations: 4     Fields:    Translation:Humans
    38. Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016 Nov 11; 291(46):23895-23905. PMID: 27655914.
      Citations: 15     Fields:    Translation:AnimalsCells
    39. Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016 Aug; 38(4):273-289. PMID: 27613724.
      Citations: 60     Fields:    Translation:HumansAnimals
    40. Tarantini S, Giles CB, Wren JD, Ashpole NM, Valcarcel-Ares MN, Wei JY, Sonntag WE, Ungvari Z, Csiszar A. IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr). 2016 Aug; 38(4):239-258. PMID: 27566308.
      Citations: 27     Fields:    Translation:AnimalsCells
    41. Luo TD, Alton TB, Apel PJ, Cai J, Barnwell JC, Sonntag WE, Smith TL, Li Z. Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury. Muscle Nerve. 2016 10; 54(4):769-75. PMID: 26970089.
      Citations: 3     Fields:    Translation:Animals
    42. Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016; 9:30. PMID: 27413395.
      Citations: 32     Fields:    
    43. Masser DR, Stanford DR, Hadad N, Giles CB, Wren JD, Sonntag WE, Richardson A, Freeman WM. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr). 2016 Jun; 38(3):49. PMID: 27091453.
      Citations: 8     Fields:    Translation:AnimalsCells
    44. Ashpole NM, Herron JC, Estep PN, Logan S, Hodges EL, Yabluchanskiy A, Humphrey MB, Sonntag WE. Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice. Age (Dordr). 2016 Apr; 38(2):38. PMID: 26968399.
      Citations: 14     Fields:    Translation:Animals
    45. Mangold CA, Masser DR, Stanford DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. J Gerontol A Biol Sci Med Sci. 2017 01; 72(1):16-29. PMID: 26786204.
      Citations: 40     Fields:    Translation:AnimalsCells
    46. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Zhang SX, Wang JJ, Sonntag WE. INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. J Clin Transl Endocrinol. 2015 Dec 01; 2(4):137-143. PMID: 26835254.
      Citations: 5     
    47. Deak F, Freeman WM, Ungvari Z, Csiszar A, Sonntag WE. Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment. J Gerontol A Biol Sci Med Sci. 2016 Jan; 71(1):13-20. PMID: 26590911.
      Citations: 21     Fields:    Translation:Humans
    48. Toth P, Tarantini S, Davila A, Valcarcel-Ares MN, Tucsek Z, Varamini B, Ballabh P, Sonntag WE, Baur JA, Csiszar A, Ungvari Z. Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex. Am J Physiol Heart Circ Physiol. 2015 Dec 01; 309(11):H1837-45. PMID: 26453330.
      Citations: 54     Fields:    Translation:AnimalsCells
    49. Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE. IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. J Bone Miner Res. 2016 Feb; 31(2):443-54. PMID: 26260312.
      Citations: 26     Fields:    Translation:AnimalsCells
    50. Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. J Cereb Blood Flow Metab. 2015 Nov; 35(11):1871-81. PMID: 26174328.
      Citations: 90     Fields:    Translation:Animals
    51. Toth P, Tarantini S, Ashpole NM, Tucsek Z, Milne GL, Valcarcel-Ares NM, Menyhart A, Farkas E, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell. 2015 Dec; 14(6):1034-44. PMID: 26172407.
      Citations: 99     Fields:    Translation:Animals
    52. Springo Z, Toth P, Tarantini S, Ashpole NM, Tucsek Z, Sonntag WE, Csiszar A, Koller A, Ungvari ZI. Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries. J Cereb Blood Flow Metab. 2015 Mar 31; 35(4):527-30. PMID: 25605292.
      Citations: 40     Fields:    Translation:Animals
    53. Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 2015 Jun; 14(3):400-8. PMID: 25677910.
      Citations: 94     Fields:    Translation:AnimalsCells
    54. Springo Z, Tarantini S, Toth P, Tucsek Z, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1355-9. PMID: 25631392.
      Citations: 45     Fields:    Translation:AnimalsCells
    55. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease. Angiology. 2015 Oct; 66(9):867-74. PMID: 25603804.
      Citations: 13     Fields:    Translation:HumansCells
    56. Ungvari Z, Sonntag WE. Brain and cerebrovascular aging--new mechanisms and insights. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1307-10. PMID: 25301834.
      Citations: 8     Fields:    Translation:HumansAnimals
    57. Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol. 2015 Aug; 68:76-81. PMID: 25300732.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    58. Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, Koller A, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. J Cereb Blood Flow Metab. 2014 Dec; 34(12):1887-97. PMID: 25248835.
      Citations: 81     Fields:    Translation:AnimalsCells
    59. Banki E, Sosnowska D, Tucsek Z, Gautam T, Toth P, Tarantini S, Tamas A, Helyes Z, Reglodi D, Sonntag WE, Csiszar A, Ungvari Z. Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):665-74. PMID: 25136000.
      Citations: 30     Fields:    Translation:AnimalsCells
    60. Yan H, Mitschelen M, Toth P, Ashpole NM, Farley JA, Hodges EL, Warrington JP, Han S, Fung KM, Csiszar A, Ungvari Z, Sonntag WE. Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1353-62. PMID: 25098324.
      Citations: 11     Fields:    Translation:AnimalsCells
    61. Ashpole NM, Warrington JP, Mitschelen MC, Yan H, Sosnowska D, Gautam T, Farley JA, Csiszar A, Ungvari Z, Sonntag WE. Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2014 Sep 15; 307(6):H858-68. PMID: 25038144.
      Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    62. Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage. 2014 Sep; 22(9):1301-9. PMID: 25008209.
      Citations: 17     Fields:    Translation:Animals
    63. Masser DR, Bixler GV, Brucklacher RM, Yan H, Giles CB, Wren JD, Sonntag WE, Freeman WM. Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1311-24. PMID: 24994846.
      Citations: 31     Fields:    Translation:AnimalsCells
    64. Csiszar A, Gautam T, Sosnowska D, Tarantini S, Banki E, Tucsek Z, Toth P, Losonczy G, Koller A, Reglodi D, Giles CB, Wren JD, Sonntag WE, Ungvari Z. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. Am J Physiol Heart Circ Physiol. 2014 Aug 01; 307(3):H292-306. PMID: 24906921.
      Citations: 91     Fields:    Translation:AnimalsCells
    65. Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1339-52. PMID: 24895269.
      Citations: 114     Fields:    Translation:AnimalsCells
    66. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease. Int J Vasc Med. 2014; 2014:160534. PMID: 24963409.
      Citations: 18     
    67. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. J Vasc Surg. 2015 May; 61(5):1249-57. PMID: 24703977.
      Citations: 32     Fields:    Translation:Humans
    68. Csiszár A, Csiszar A, Pinto JT, Gautam T, Kleusch C, Hoffmann B, Tucsek Z, Toth P, Sonntag WE, Ungvari Z. Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats. J Gerontol A Biol Sci Med Sci. 2015 Mar; 70(3):303-13. PMID: 24642904.
      Citations: 35     Fields:    Translation:AnimalsCells
    69. Sosnowska D, Richardson C, Sonntag WE, Csiszar A, Ungvari Z, Ridgway I. A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal. J Gerontol A Biol Sci Med Sci. 2014 Dec; 69(12):1448-61. PMID: 24347613.
      Citations: 10     Fields:    Translation:AnimalsCells
    70. Toth P, Tarantini S, Tucsek Z, Ashpole NM, Sosnowska D, Gautam T, Ballabh P, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H299-308. PMID: 24322615.
      Citations: 118     Fields:    Translation:Animals
    71. Tucsek Z, Toth P, Sosnowska D, Gautam T, Mitschelen M, Koller A, Szalai G, Sonntag WE, Ungvari Z, Csiszar A. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1212-26. PMID: 24269929.
      Citations: 165     Fields:    Translation:Animals
    72. Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Schwartzman ML, Sonntag WE, Ungvari Z. Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1698-708. PMID: 24097425.
      Citations: 61     Fields:    Translation:AnimalsCells
    73. Warrington JP, Ashpole N, Csiszar A, Lee YW, Ungvari Z, Sonntag WE. Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. J Vasc Res. 2013; 50(6):445-57. PMID: 24107797.
      Citations: 42     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    74. Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Esponda OL, Ungvari Z, Csiszar A, Sonntag WE. Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease. Angiology. 2014 Sep; 65(8):683-90. PMID: 24006146.
      Citations: 30     Fields:    Translation:Humans
    75. Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in ß-amyloid generation and Alzheimer's disease. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1120-30. PMID: 23955715.
      Citations: 37     Fields:    Translation:Animals
    76. Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deak F, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. J Cereb Blood Flow Metab. 2013 Nov; 33(11):1732-42. PMID: 23942363.
      Citations: 133     Fields:    Translation:AnimalsCells
    77. Sonntag WE, Deak F, Ashpole N, Toth P, Csiszar A, Freeman W, Ungvari Z. Insulin-like growth factor-1 in CNS and cerebrovascular aging. Front Aging Neurosci. 2013; 5:27. PMID: 23847531.
      Citations: 74     
    78. Ungvari Z, Podlutsky A, Sosnowska D, Tucsek Z, Toth P, Deak F, Gautam T, Csiszar A, Sonntag WE. Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity. J Gerontol A Biol Sci Med Sci. 2013 Dec; 68(12):1443-57. PMID: 23689827.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    79. Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A. Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. Br J Pharmacol. 2013 Apr; 168(8):1878-88. PMID: 23194285.
      Citations: 25     Fields:    Translation:AnimalsCells
    80. VanGuilder Starkey HD, Bixler GV, Sonntag WE, Freeman WM. Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cell Mol Neurobiol. 2013 May; 33(4):483-8. PMID: 23525710.
      Citations: 12     Fields:    Translation:Animals
    81. VanGuilder Starkey HD, Sonntag WE, Freeman WM. Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. Eur J Neurosci. 2013 May; 37(10):1643-58. PMID: 23438185.
      Citations: 16     Translation:AnimalsCells
    82. Ungvari Z, Tucsek Z, Sosnowska D, Toth P, Gautam T, Podlutsky A, Csiszar A, Losonczy G, Valcarcel-Ares MN, Sonntag WE, Csiszar A. Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci. 2013 Aug; 68(8):877-91. PMID: 23239824.
      Citations: 75     Fields:    Translation:AnimalsCells
    83. Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):780-92. PMID: 23213032.
      Citations: 75     Fields:    Translation:AnimalsCells
    84. Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Salomao R, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J Gerontol A Biol Sci Med Sci. 2013 Jun; 68(6):652-60. PMID: 23183901.
      Citations: 25     Fields:    Translation:HumansAnimals
    85. Ungvari Z, Sosnowska D, Mason JB, Gruber H, Lee SW, Schwartz TS, Brown MK, Storm NJ, Fortney K, Sowa J, Byrne AB, Kurz T, Levy E, Sonntag WE, Austad SN, Csiszar A, Ridgway I. Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype? J Gerontol A Biol Sci Med Sci. 2013 May; 68(5):521-9. PMID: 23051979.
      Citations: 11     Fields:    Translation:Animals
    86. Ungvari Z, Csiszar A, Sosnowska D, Philipp EE, Campbell CM, McQuary PR, Chow TT, Coelho M, Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sonntag WE, Whitby PW, Austad SN, Ridgway I. Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). J Gerontol A Biol Sci Med Sci. 2013 Apr; 68(4):359-67. PMID: 22904097.
      Citations: 15     Fields:    Translation:AnimalsCells
    87. Csiszar A, Sosnowska D, Tucsek Z, Gautam T, Toth P, Losonczy G, Colman RJ, Weindruch R, Anderson RM, Sonntag WE, Ungvari Z. Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci. 2013 Mar; 68(3):235-49. PMID: 22904098.
      Citations: 40     Fields:    Translation:AnimalsCells
    88. Lee YW, Cho HJ, Lee WH, Sonntag WE. Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets. Biomol Ther (Seoul). 2012 Jul; 20(4):357-70. PMID: 24009822.
      Citations: 37     
    89. Tanaka M, Jaruga P, Küpfer PA, Leumann CJ, Dizdaroglu M, Sonntag WE, Boon Chock P. RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria. Free Radic Biol Med. 2012 Aug 15; 53(4):854-62. PMID: 22683603.
      Citations: 6     Fields:    Translation:AnimalsCells
    90. VanGuilder Starkey HD, Van Kirk CA, Bixler GV, Imperio CG, Kale VP, Serfass JM, Farley JA, Yan H, Warrington JP, Han S, Mitschelen M, Sonntag WE, Freeman WM. Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. J Mol Neurosci. 2012 Sep; 48(1):111-26. PMID: 22562814.
      Citations: 41     Fields:    Translation:AnimalsCells
    91. Sonntag WE, Csiszar A, deCabo R, Ferrucci L, Ungvari Z. Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):587-98. PMID: 22522510.
      Citations: 46     Fields:    Translation:HumansAnimals
    92. Deak F, Sonntag WE. Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):611-25. PMID: 22503992.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    93. Lee WH, Warrington JP, Sonntag WE, Lee YW. Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. Int J Radiat Oncol Biol Phys. 2012 Apr 01; 82(5):1559-66. PMID: 22429332.
      Citations: 36     Fields:    Translation:AnimalsCellsPHPublic Health
    94. Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM. Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. J Neurochem. 2012 Apr; 121(1):77-98. PMID: 22269040.
      Citations: 23     Fields:    Translation:Animals
    95. Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE. Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia. PLoS One. 2012; 7(1):e30444. PMID: 22279591.
      Citations: 40     Fields:    Translation:AnimalsPHPublic Health
    96. Csiszar A, Podlutsky A, Podlutskaya N, Sonntag WE, Merlin SZ, Philipp EE, Doyle K, Davila A, Recchia FA, Ballabh P, Pinto JT, Ungvari Z. Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci. 2012 Aug; 67(8):841-52. PMID: 22219516.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    97. Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. J Gerontol A Biol Sci Med Sci. 2012 Aug; 67(8):811-20. PMID: 22219513.
      Citations: 93     Fields:    Translation:AnimalsCells
    98. Valcarcel-Ares MN, Gautam T, Warrington JP, Bailey-Downs L, Sosnowska D, de Cabo R, Losonczy G, Sonntag WE, Ungvari Z, Csiszar A. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci. 2012 Aug; 67(8):821-9. PMID: 22219515.
      Citations: 89     Fields:    Translation:HumansCells
    99. Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z. Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):553-64. PMID: 22080499.
      Citations: 51     Fields:    Translation:Animals
    100. Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behav Brain Res. 2012 Feb 01; 227(1):258-64. PMID: 22085876.
      Citations: 14     Fields:    Translation:AnimalsCells
    101. Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):313-29. PMID: 22021391.
      Citations: 104     Fields:    Translation:Animals
    102. Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012 Sep; 33(9):1938-49. PMID: 22015312.
      Citations: 17     Fields:    Translation:AnimalsCells
    103. VanGuilder HD, Bixler GV, Brucklacher RM, Farley JA, Yan H, Warrington JP, Sonntag WE, Freeman WM. Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. J Neuroinflammation. 2011 Oct 11; 8:138. PMID: 21989322.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    104. Lee WH, Cho HJ, Sonntag WE, Lee YW. Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain. Radiat Res. 2011 Dec; 176(6):753-60. PMID: 21962003.
      Citations: 16     Fields:    Translation:AnimalsCells
    105. Yan H, Mitschelen M, Bixler GV, Brucklacher RM, Farley JA, Han S, Freeman WM, Sonntag WE. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. J Endocrinol. 2011 Oct; 211(1):27-37. PMID: 21750148.
      Citations: 31     Fields:    Translation:Animals
    106. Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A. Mitochondrial protection by resveratrol. Exerc Sport Sci Rev. 2011 Jul; 39(3):128-32. PMID: 21383627.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    107. Tanaka M, Han S, Küpfer PA, Leumann CJ, Sonntag WE. Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe. Anal Biochem. 2011 Oct 01; 417(1):142-8. PMID: 21693097.
      Citations: 7     Fields:    Translation:HumansCells
    108. Ungvari Z, Bailey-Downs L, Gautam T, Sosnowska D, Wang M, Monticone RE, Telljohann R, Pinto JT, de Cabo R, Sonntag WE, Lakatta EG, Csiszar A. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci. 2011 Aug; 66(8):866-75. PMID: 21622983.
      Citations: 125     Fields:    Translation:AnimalsCells
    109. Ungvari Z, Bailey-Downs L, Sosnowska D, Gautam T, Koncz P, Losonczy G, Ballabh P, de Cabo R, Sonntag WE, Csiszar A. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol. 2011 Aug; 301(2):H363-72. PMID: 21602469.
      Citations: 144     Fields:    Translation:Animals
    110. Van Kirk CA, VanGuilder HD, Young M, Farley JA, Sonntag WE, Freeman WM. Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol Vis. 2011; 17:1261-74. PMID: 21633715.
      Citations: 17     Fields:    Translation:AnimalsCells
    111. Mitschelen M, Yan H, Farley JA, Warrington JP, Han S, Hereñú CB, Csiszar A, Ungvari Z, Bailey-Downs LC, Bass CE, Sonntag WE. Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression. Neuroscience. 2011 Jun 30; 185:50-60. PMID: 21524689.
      Citations: 44     Fields:    Translation:AnimalsCells
    112. Ungvari Z, Ridgway I, Philipp EE, Campbell CM, McQuary P, Chow T, Coelho M, Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sosnowska D, Sonntag WE, Austad SN, Csiszar A. Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. J Gerontol A Biol Sci Med Sci. 2011 Jul; 66(7):741-50. PMID: 21486920.
      Citations: 46     Fields:    Translation:Animals
    113. VanGuilder HD, Farley JA, Yan H, Van Kirk CA, Mitschelen M, Sonntag WE, Freeman WM. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiol Dis. 2011 Jul; 43(1):201-12. PMID: 21440628.
      Citations: 67     Fields:    Translation:AnimalsCells
    114. Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res. 2011 Apr; 21(2):81-8. PMID: 21371927.
      Citations: 6     Fields:    Translation:HumansAnimals
    115. Ungvari Z, Sosnowska D, Podlutsky A, Koncz P, Sonntag WE, Csiszar A. Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment. J Gerontol A Biol Sci Med Sci. 2011 May; 66(5):501-10. PMID: 21350246.
      Citations: 32     Fields:    Translation:AnimalsCells
    116. Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1133-40. PMID: 21217061.
      Citations: 98     Fields:    Translation:AnimalsCells
    117. Warrington JP, Csiszar A, Johnson DA, Herman TS, Ahmad S, Lee YW, Sonntag WE. Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice. Am J Physiol Heart Circ Physiol. 2011 Mar; 300(3):H736-44. PMID: 21186274.
      Citations: 36     Fields:    Translation:AnimalsCells
    118. Tanaka M, Han S, Song H, Küpfer PA, Leumann CJ, Sonntag WE. An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. Free Radic Res. 2011 Feb; 45(2):237-47. PMID: 21062214.
      Citations: 17     Fields:    Translation:HumansCells
    119. Zuo Z, Lei H, Wang X, Wang Y, Sonntag W, Sun Z. Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordr). 2011 Sep; 33(3):261-74. PMID: 20830528.
      Citations: 25     Fields:    Translation:Animals
    120. Ungvari Z, Sonntag WE, Csiszar A. Mitochondria and aging in the vascular system. J Mol Med (Berl). 2010 Oct; 88(10):1021-7. PMID: 20714704.
      Citations: 40     Fields:    Translation:HumansCells
    121. Ungvari Z, Gautam T, Koncz P, Henthorn JC, Pinto JT, Ballabh P, Yan H, Mitschelen M, Farley J, Sonntag WE, Csiszar A. Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci. 2010 Nov; 65(11):1145-56. PMID: 20713653.
      Citations: 36     Fields:    Translation:Animals
    122. Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci. 2010 Oct; 65(10):1028-41. PMID: 20576649.
      Citations: 243     Fields:    Translation:HumansAnimalsCells
    123. Zhao W, Aboushwareb T, Turner C, Mathis C, Bennett C, Sonntag WE, Andersson KE, Christ G. Impaired bladder function in aging male rats. J Urol. 2010 Jul; 184(1):378-85. PMID: 20488483.
      Citations: 24     Fields:    Translation:Animals
    124. Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H18-24. PMID: 20418481.
      Citations: 253     Fields:    Translation:HumansAnimalsCells
    125. Lee WH, Sonntag WE, Lee YW. Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neurosci Lett. 2010 May 31; 476(2):89-93. PMID: 20385203.
      Citations: 18     Fields:    Translation:Animals
    126. VanGuilder HD, Yan H, Farley JA, Sonntag WE, Freeman WM. Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. J Neurochem. 2010 Jun; 113(6):1577-88. PMID: 20374424.
      Citations: 72     Fields:    Translation:AnimalsCells
    127. Apel PJ, Ma J, Callahan M, Northam CN, Alton TB, Sonntag WE, Li Z. Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats. Muscle Nerve. 2010 Mar; 41(3):335-41. PMID: 19802878.
      Citations: 52     Fields:    Translation:AnimalsCells
    128. Lee WH, Sonntag WE, Mitschelen M, Yan H, Lee YW. Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int J Radiat Biol. 2010 Feb; 86(2):132-44. PMID: 20148699.
      Citations: 78     Fields:    Translation:AnimalsCells
    129. Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J Endocrinol. 2010 Jan; 204(1):31-6. PMID: 19815586.
      Citations: 34     Fields:    Translation:Animals
    130. Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE. Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience. 2009 Dec 15; 164(3):918-28. PMID: 19735701.
      Citations: 15     Fields:    Translation:Animals
    131. Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 2009 Aug 01; 57(10):1062-71. PMID: 19115393.
      Citations: 19     Fields:    Translation:AnimalsCells
    132. Hereñú CB, Sonntag WE, Morel GR, Portiansky EL, Goya RG. The ependymal route for insulin-like growth factor-1 gene therapy in the brain. Neuroscience. 2009 Sep 29; 163(1):442-7. PMID: 19531373.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    133. Adams MM, Elizabeth Forbes M, Constance Linville M, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors. 2009 Jun; 27(3):181-8. PMID: 19343576.
      Citations: 17     Fields:    Translation:Animals
    134. Apel PJ, Alton T, Northam C, Ma J, Callahan M, Sonntag WE, Li Z. How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats. J Orthop Res. 2009 Mar; 27(3):385-93. PMID: 18853430.
      Citations: 21     Fields:    Translation:AnimalsCells
    135. Freeman WM, VanGuilder HD, Bennett C, Sonntag WE. Cognitive performance and age-related changes in the hippocampal proteome. Neuroscience. 2009 Mar 03; 159(1):183-95. PMID: 19135133.
      Citations: 21     Fields:    Translation:AnimalsCells
    136. Carnes BA, Staats DO, Sonntag WE. Does senescence give rise to disease? Mech Ageing Dev. 2008 Dec; 129(12):693-9. PMID: 18977242.
      Citations: 9     Fields:    Translation:HumansAnimals
    137. Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats. J Gerontol A Biol Sci Med Sci. 2008 Sep; 63(9):911-20. PMID: 18840795.
      Citations: 12     Fields:    Translation:Animals
    138. Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Sonntag WE, Riddle DR, Brunso-Bechtold JK. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol. 2008 May; 211(1):141-9. PMID: 18342310.
      Citations: 71     Fields:    Translation:Animals
    139. Ingraham JP, Forbes ME, Riddle DR, Sonntag WE. Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus. J Gerontol A Biol Sci Med Sci. 2008 Jan; 63(1):12-20. PMID: 18245756.
      Citations: 33     Fields:    Translation:Animals
    140. You T, Sonntag WE, Leng X, Carter CS. Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats. J Gerontol A Biol Sci Med Sci. 2007 Oct; 62(10):1082-7. PMID: 17921419.
      Citations: 13     Fields:    Translation:Animals
    141. Braverman ER, Chen TJ, Prihoda TJ, Sonntag W, Meshkin B, Downs BW, Mengucci JF, Blum SH, Notaro A, Arcuri V, Varshavskiy M, Blum K. Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: evidence supported by structural equation modeling (SEM) parameter estimates. Age (Dordr). 2007 Sep; 29(2-3):55-67. PMID: 19424831.
      Citations: 2     Fields:    
    142. Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis Rheum. 2006 Dec; 54(12):3850-8. PMID: 17133593.
      Citations: 29     Fields:    Translation:Animals
    143. Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R, Brunso-Bechtold JK. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res. 2006 Dec; 166(6):892-9. PMID: 17149974.
      Citations: 78     Fields:    Translation:AnimalsPHPublic Health
    144. Sonntag WE, Bennett C, Ingram R, Donahue A, Ingraham J, Chen H, Moore T, Brunso-Bechtold JK, Riddle D. Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E604-10. PMID: 16912061.
      Citations: 22     Fields:    Translation:Animals
    145. Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. J Neurosci Res. 2006 Feb 01; 83(2):199-210. PMID: 16385581.
      Citations: 23     Fields:    Translation:AnimalsCells
    146. Groban L, Pailes NA, Bennett CD, Carter CS, Chappell MC, Kitzman DW, Sonntag WE. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. J Gerontol A Biol Sci Med Sci. 2006 Jan; 61(1):28-35. PMID: 16456192.
      Citations: 41     Fields:    Translation:Animals
    147. Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag WE. Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mech Ageing Dev. 2006 Jan; 127(1):57-63. PMID: 16243379.
      Citations: 15     Fields:    Translation:AnimalsCells
    148. Grill JD, Sonntag WE, Riddle DR. Dendritic stability in a model of adult-onset IGF-I deficiency. Growth Horm IGF Res. 2005 Oct; 15(5):337-48. PMID: 16143551.
      Citations: 3     Fields:    Translation:AnimalsCells
    149. Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics. 2005 Nov 17; 23(3):311-7. PMID: 16131528.
      Citations: 34     Fields:    Translation:AnimalsCells
    150. Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol. 2005 Jul; 94(1):247-54. PMID: 15985695.
      Citations: 45     Fields:    Translation:AnimalsCells
    151. Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev. 2005 May; 4(2):195-212. PMID: 16024298.
      Citations: 112     Fields:    Translation:HumansAnimals
    152. Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M. Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology. 2005 Jul; 146(7):2920-32. PMID: 15790724.
      Citations: 71     Fields:    Translation:Animals
    153. Shi L, Linville MC, Tucker EW, Sonntag WE, Brunso-Bechtold JK. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cereb Cortex. 2005 May; 15(5):571-7. PMID: 15319312.
      Citations: 40     Fields:    Translation:AnimalsCells
    154. Butler RN, Sprott R, Warner H, Bland J, Feuers R, Forster M, Fillit H, Harman SM, Hewitt M, Hyman M, Johnson K, Kligman E, McClearn G, Nelson J, Richardson A, Sonntag W, Weindruch R, Wolf N. Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci. 2004 Jun; 59(6):B560-7. PMID: 15215265.
      Citations: 68     Fields:    Translation:HumansAnimals
    155. Carter CS, Cesari M, Ambrosius WT, Hu N, Diz D, Oden S, Sonntag WE, Pahor M. Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. J Gerontol A Biol Sci Med Sci. 2004 May; 59(5):416-23. PMID: 15123750.
      Citations: 36     Fields:    Translation:Animals
    156. Ramsey MM, Weiner JL, Moore TP, Carter CS, Sonntag WE. Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience. 2004; 129(1):119-27. PMID: 15489035.
      Citations: 43     Fields:    Translation:Animals
    157. Riddle DR, Sonntag WE, Lichtenwalner RJ. Microvascular plasticity in aging. Ageing Res Rev. 2003 Apr; 2(2):149-68. PMID: 12605958.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    158. Sonntag WE, Ramsey MM. Of worms, flies, dwarfs, and things that go bump in the night. Sci Aging Knowledge Environ. 2002 Oct 30; 2002(43):pe17. PMID: 14603010.
      Citations: 1     Fields:    Translation:Animals
    159. Ramsey MM, Ingram RL, Cashion AB, Ng AH, Cline JM, Parlow AF, Sonntag WE. Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 2002 Oct; 143(10):4139-42. PMID: 12239127.
      Citations: 32     Fields:    Translation:Animals
    160. Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 2002 Jun; 18(6):295-301. PMID: 12044358.
      Citations: 53     Fields:    Translation:Animals
    161. Carter CS, Ramsey MM, Ingram RL, Cashion AB, Cefalu WT, Wang ZQ, Sonntag WE. Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination. J Gerontol A Biol Sci Med Sci. 2002 May; 57(5):B177-88. PMID: 11983714.
      Citations: 24     Fields:    Translation:HumansAnimals
    162. Carter CS, Sonntag WE, Onder G, Pahor M. Physical performance and longevity in aged rats. J Gerontol A Biol Sci Med Sci. 2002 May; 57(5):B193-7. PMID: 11983716.
      Citations: 29     Fields:    Translation:Animals
    163. Khan AS, Sane DC, Wannenburg T, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc Res. 2002 Apr; 54(1):25-35. PMID: 12062358.
      Citations: 63     Fields:    Translation:HumansAnimals
    164. Shi L, Poe BH, Constance Linville M, Sonntag WE, Brunso-Bechtold JK. Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex. Brain Res. 2002 Mar 22; 931(1):32-40. PMID: 11897086.
      Citations: 4     Fields:    Translation:AnimalsCells
    165. Poe BH, Linville MC, Sonntag WE, Brunso-Bechtold JK. Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan; 26(1):97-102. PMID: 11853126.
      Citations:    Fields:    Translation:AnimalsCells
    166. Wannenburg T, Khan AS, Sane DC, Willingham MC, Faucette T, Sonntag WE. Growth hormone reverses age-related cardiac myofilament dysfunction in rats. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H915-22. PMID: 11454598.
      Citations: 4     Fields:    Translation:Animals
    167. Khan AS, Lynch CD, Sane DC, Willingham MC, Sonntag WE. Growth hormone increases regional coronary blood flow and capillary density in aged rats. J Gerontol A Biol Sci Med Sci. 2001 Aug; 56(8):B364-71. PMID: 11487595.
      Citations: 17     Fields:    Translation:Animals
    168. Carter CS, Pahor M, Sonntag WE. Assessment of physical function in aging rodents: a strategy for improving preclinical testing. Exp Aging Res. 2001 Jul-Sep; 27(3):271-82. PMID: 11441648.
      Citations:    Fields:    Translation:HumansAnimals
    169. Lynch CD, Lyons D, Khan A, Bennett SA, Sonntag WE. Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology. 2001 Jan; 142(1):506-9. PMID: 11145617.
      Citations: 15     Fields:    Translation:Animals
    170. Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, Riddle DR. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience. 2001; 107(4):603-13. PMID: 11720784.
      Citations: 145     Fields:    Translation:Animals
    171. Poe BH, Linville C, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus. Neuroscience. 2001; 107(2):231-8. PMID: 11731097.
      Citations: 16     Fields:    Translation:AnimalsCells
    172. Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S, Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J Anat. 2000 Nov; 197 Pt 4:575-85. PMID: 11197531.
      Citations: 64     Fields:    Translation:HumansAnimals
    173. Loeser RF, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum. 2000 Sep; 43(9):2110-20. PMID: 11014363.
      Citations: 62     Fields:    Translation:AnimalsCells
    174. Brunso-Bechtold JK, Linville MC, Sonntag WE. Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat. Brain Res. 2000 Jul 28; 872(1-2):125-33. PMID: 10924684.
      Citations: 11     Fields:    Translation:AnimalsCells
    175. Cefalu WT, Wang ZQ, Bell-Farrow AD, Terry JG, Sonntag W, Waite M, Parks J. Chronic caloric restriction alters muscle membrane fatty acid content. Exp Gerontol. 2000 May; 35(3):331-41. PMID: 10832054.
      Citations: 7     Fields:    Translation:HumansAnimals
    176. Sonntag WE, Bennett SA, Khan AS, Thornton PL, Xu X, Ingram RL, Brunso-Bechtold JK. Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats. Brain Res Bull. 2000 Mar 01; 51(4):331-8. PMID: 10704784.
      Citations: 50     Fields:    Translation:Animals
    177. Thornton PL, Ingram RL, Sonntag WE. Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. J Gerontol A Biol Sci Med Sci. 2000 Feb; 55(2):B106-12. PMID: 10737685.
      Citations: 25     Fields:    Translation:Animals
    178. Sonntag WE, Lynch CD, Cefalu WT, Ingram RL, Bennett SA, Thornton PL, Khan AS. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J Gerontol A Biol Sci Med Sci. 1999 Dec; 54(12):B521-38. PMID: 10647962.
      Citations: 63     Fields:    Translation:Animals
    179. Lynch CD, Cooney PT, Bennett SA, Thornton PL, Khan AS, Ingram RL, Sonntag WE. Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiol Aging. 1999 Mar-Apr; 20(2):191-200. PMID: 10537028.
      Citations: 27     Fields:    Translation:Animals
    180. Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T, Brunso-Bechtold JK. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience. 1999 Jan; 88(1):269-79. PMID: 10051206.
      Citations: 38     Fields:    Translation:AnimalsCells
    181. Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 1998 Dec; 87(3):559-69. PMID: 9758223.
      Citations: 83     Fields:    Translation:HumansAnimals
    182. Niblock MM, Brunso-Bechtold JK, Lynch CD, Ingram RL, McShane T, Sonntag WE. Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain. Brain Res. 1998 Aug 31; 804(1):79-86. PMID: 9729292.
      Citations: 15     Fields:    Translation:Animals
    183. Wang ZQ, Bell-Farrow AD, Sonntag W, Cefalu WT. Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats. Exp Gerontol. 1997 Nov-Dec; 32(6):671-84. PMID: 9785093.
      Citations: 18     Fields:    Translation:AnimalsCells
    184. Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 1997 Aug; 138(8):3515-20. PMID: 9231806.
      Citations: 118     Fields:    Translation:Animals
    185. Renganathan M, Sonntag WE, Delbono O. L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):784-9. PMID: 9207239.
      Citations: 11     Fields:    Translation:AnimalsCells
    186. Xu X, Sonntag WE. Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction. Am J Physiol. 1996 Nov; 271(5 Pt 1):E903-9. PMID: 8944679.
      Citations: 7     Fields:    Translation:AnimalsCells
    187. Breese CR, D'Costa A, Rollins YD, Adams C, Booze RM, Sonntag WE, Leonard S. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. J Comp Neurol. 1996 Jun 03; 369(3):388-404. PMID: 8743420.
      Citations: 20     Fields:    Translation:AnimalsCells
    188. Xu X, Sonntag WE. Growth hormone and aging: Regulation, signal transduction and replacement therapy. Trends Endocrinol Metab. 1996 May-Jun; 7(4):145-50. PMID: 18406741.
      Citations: 2     Fields:    
    189. Xu X, Sonntag WE. Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction. J Gerontol A Biol Sci Med Sci. 1996 Mar; 51(2):B167-74. PMID: 8612101.
      Citations: 2     Fields:    Translation:AnimalsCells
    190. Cefalu WT, Bell-Farrow AD, Wang ZQ, Sonntag WE, Fu MX, Baynes JW, Thorpe SR. Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen. J Gerontol A Biol Sci Med Sci. 1995 Nov; 50(6):B337-41. PMID: 7583789.
      Citations: 25     Fields:    Translation:AnimalsCells
    191. Xu X, Bennett SA, Ingram RL, Sonntag WE. Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. Endocrinology. 1995 Oct; 136(10):4551-7. PMID: 7664676.
      Citations: 11     Fields:    Translation:AnimalsCells
    192. Xu X, Ingram RL, Sonntag WE. Ethanol suppresses growth hormone-mediated cellular responses in liver slices. Alcohol Clin Exp Res. 1995 Oct; 19(5):1246-51. PMID: 8561297.
      Citations: 3     Fields:    Translation:AnimalsCells
    193. Breese CR, Sonntag WE. Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcohol Clin Exp Res. 1995 Aug; 19(4):867-73. PMID: 7485832.
      Citations: 5     Fields:    Translation:Animals
    194. Sonntag WE, Xu X, Ingram RL, D'Costa A. Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals. Neuroendocrinology. 1995 May; 61(5):601-8. PMID: 7617139.
      Citations: 12     Fields:    Translation:AnimalsCells
    195. D'Costa AP, Xu X, Ingram RL, Sonntag WE. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. 1995 Apr; 65(3):805-13. PMID: 7609879.
      Citations: 7     Fields:    Translation:Animals
    196. Breese CR, D'Costa A, Sonntag WE. Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain. Neuroscience. 1994 Nov; 63(2):579-89. PMID: 7891866.
      Citations: 6     Fields:    Translation:Animals
    197. D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mech Ageing Dev. 1993 Oct 01; 71(1-2):59-71. PMID: 7508538.
      Citations: 9     Fields:    Translation:AnimalsCells
    198. D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors. Ann N Y Acad Sci. 1993 Aug 27; 692:253-5. PMID: 8215027.
      Citations: 2     Fields:    Translation:AnimalsCells
    199. D'Costa AP, Ingram RL, Lenham JE, Sonntag WE. The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing. J Reprod Fertil Suppl. 1993; 46:87-98. PMID: 8315618.
      Citations: 16     Fields:    Translation:AnimalsCells
    200. Breese CR, D'Costa A, Ingram RL, Lenham J, Sonntag WE. Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth. J Pharmacol Exp Ther. 1993 Jan; 264(1):448-56. PMID: 7678650.
      Citations: 12     Fields:    Translation:Animals
    201. Sonntag WE, Lenham JE, Ingram RL. Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1. J Gerontol. 1992 Sep; 47(5):B159-63. PMID: 1387410.
      Citations: 10     Fields:    Translation:AnimalsCells
    202. D'Costa A, Breese CR, Boyd RL, Booze RM, Sonntag WE. Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice. Brain Res. 1991 Dec 20; 567(2):204-11. PMID: 1687805.
      Citations: 7     Fields:    Translation:Animals
    203. Breese CR, Ingram RL, Sonntag WE. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol. 1991 Sep; 46(5):B180-7. PMID: 1716275.
      Citations: 64     Fields:    Translation:AnimalsCells
    204. Spik KW, Boyd RL, Sonntag WE. Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture. J Gerontol. 1991 Mar; 46(2):B72-7. PMID: 1997567.
      Citations: 2     Fields:    Translation:AnimalsCells
    205. Breese CR, D'Costa A, Booze RM, Sonntag WE. Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice. Adv Exp Med Biol. 1991; 293:449-58. PMID: 1662866.
      Citations: 4     Fields:    Translation:AnimalsCells
    206. Sonntag WE, Boyd RL, Booze RM. Somatostatin gene expression in hypothalamus and cortex of aging male rats. Neurobiol Aging. 1990 Jul-Aug; 11(4):409-16. PMID: 1974326.
      Citations: 3     Fields:    Translation:AnimalsCells
    207. Spik K, Sonntag WE. Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity. Neuroendocrinology. 1989 Nov; 50(5):489-94. PMID: 2575235.
      Citations: 4     Fields:    Translation:Animals
    208. Sonntag WE, Boyd RL. Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcohol Clin Exp Res. 1989 Feb; 13(1):3-7. PMID: 2646974.
      Citations: 4     Fields:    Translation:Animals
    209. Sonntag WE, Gough MA. Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release. Neuroendocrinology. 1988 Jun; 47(6):482-8. PMID: 2840597.
      Citations: 1     Fields:    Translation:Animals
    210. Sonntag WE, Boyd RL. Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1. Life Sci. 1988; 43(16):1325-30. PMID: 3172983.
      Citations: 7     Fields:    Translation:Animals
    211. Sonntag WE, Goliszek AG, Brodish A, Eldridge JC. Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo. Endocrinology. 1987 Jun; 120(6):2308-15. PMID: 3032584.
      Citations: 10     Fields:    Translation:Animals
    212. Sonntag WE, Gottschall PE, Meites J. Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro. Brain Res. 1986 Aug 20; 380(2):229-34. PMID: 2875760.
      Citations: 6     Fields:    Translation:AnimalsCells
    213. Hylka VW, Forman LJ, Sonntag WE, Meites J. Effect of CNS-active drugs on TRH-induced prolactin release. Life Sci. 1986 Jan 06; 38(1):51-7. PMID: 2934599.
      Citations:    Fields:    Translation:Animals
    214. Sonntag WE, Hylka VW, Meites J. Growth hormone restores protein synthesis in skeletal muscle of old male rats. J Gerontol. 1985 Nov; 40(6):689-94. PMID: 4056323.
      Citations: 5     Fields:    Translation:Animals
    215. Forman LJ, Sonntag WE, Hylka VW, Meites J. Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats. Peptides. 1985 Sep-Oct; 6(5):835-9. PMID: 2934689.
      Citations: 1     Fields:    Translation:Animals
    216. Forman LJ, Sonntag WE, Hylka VW, Meites J. Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats. Experientia. 1985 May 15; 41(5):653-4. PMID: 2860005.
      Citations: 6     Fields:    Translation:Animals
    217. Sonntag WE, Forman LJ, Fiori JM, Hylka VW, Meites J. Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors. Endocrinology. 1984 May; 114(5):1657-64. PMID: 6325129.
      Citations: 6     Fields:    Translation:Animals
    218. Hylka VW, Sonntag WE, Meites J. Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration. Proc Soc Exp Biol Med. 1984 Jan; 175(1):1-4. PMID: 6320204.
      Citations: 4     Fields:    Translation:Animals
    219. Sonntag WE, Hylka VW, Meites J. Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44). Endocrinology. 1983 Dec; 113(6):2305-7. PMID: 6416817.
      Citations: 6     Fields:    Translation:Animals
    220. Forman LJ, Sonntag WE, Hylka VW, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats. Life Sci. 1983 Sep 05; 33(10):993-9. PMID: 6310292.
      Citations: 1     Fields:    Translation:Animals
    221. Forman LJ, Sonntag WE, Meites J. Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats. Proc Soc Exp Biol Med. 1983 May; 173(1):14-6. PMID: 6304744.
      Citations: 2     Fields:    Translation:Animals
    222. Steger RW, Sonntag WE, Peluso JJ, Meites J. Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats. Neurobiol Aging. 1983; 4(1):53-7. PMID: 6348573.
      Citations: 3     Fields:    Translation:Animals
    223. Sonntag WE, Forman LJ, Miki N, Trapp JM, Gottschall PE, Meites J. L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats. Neuroendocrinology. 1982 Mar; 34(3):163-8. PMID: 6122169.
      Citations: 1     Fields:    Translation:Animals
    224. Thoenes W, Sonntag W, Heine WD, Langer KH. Cell fusion as a mechanism for the formation of giant cells (Langhans' type). Autoradiographic findings in autoimmune tubulo-interstitial nephritis of the rat. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982; 41(1-2):45-50. PMID: 6134383.
      Citations:    Fields:    Translation:Animals
    225. Miki N, Sonntag WE, Forman LJ, Meites J. Suppression by naloxone of rise in plasma growth hormone and prolactin induced by sucking. Proc Soc Exp Biol Med. 1981 Dec; 168(3):330-3. PMID: 7198792.
      Citations: 2     Fields:    Translation:Animals
    226. Sonntag WE, Forman LJ, Miki N, Steger RW, Ramos T, Arimura A, Meites J. Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats. Neuroendocrinology. 1981 Aug; 33(2):73-8. PMID: 6115331.
      Citations: 9     Fields:    Translation:Animals
    227. Forman LJ, Sonntag WE, Miki N, Ramos T, Meites J. Comparison of the effects of central acting drugs on prolactin release in young and old male rats. Proc Soc Exp Biol Med. 1981 Jul; 167(3):354-8. PMID: 6454894.
      Citations: 1     Fields:    Translation:Animals
    228. Forman LJ, Sonntag WE, Van Vugt DA, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats. Neurobiol Aging. 1981; 2(4):281-4. PMID: 6278345.
      Citations: 2     Fields:    Translation:Animals
    229. Meites J, Sonntag WE. Hypothalamic hypophysiotropic hormones and neurotransmitter regulation: current views. Annu Rev Pharmacol Toxicol. 1981; 21:295-322. PMID: 6112966.
      Citations: 12     Fields:    Translation:HumansAnimals
    230. Forman LJ, Sonntag WE, Miki N, Meites J. Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats. Exp Aging Res. 1980 Dec; 6(6):547-54. PMID: 7194183.
      Citations: 4     Fields:    Translation:Animals
    231. Sonntag WE, Steger RW, Forman LJ, Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology. 1980 Dec; 107(6):1875-9. PMID: 7428695.
      Citations: 45     Fields:    Translation:Animals
    232. Steger RW, Sonntag WE, Van Vugt DA, Forman LJ, Meites J. Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin. Life Sci. 1980 Sep 01; 27(9):747-53. PMID: 7412501.
      Citations: 1     Fields:    Translation:Animals
    233. Gerall AA, Dunlap JL, Sonntag WE. Reproduction in aging normal and neonatally androgenized female rats. J Comp Physiol Psychol. 1980 Jun; 94(3):556-63. PMID: 7391285.
      Citations: 1     Fields:    Translation:Animals
    234. Huang HH, Steger RW, Sonntag WE, Meites J. Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats. Neurobiol Aging. 1980; 1(2):141-3. PMID: 24279937.
      Citations: 1     Fields:    
    235. Paulini K, Sonntag W. [Polyploidisation - a phenomenon of aging? (author's transl)]. Aktuelle Gerontol. 1977 Oct; 7(10):521-7. PMID: 22253.
      Citations: 2     Fields:    Translation:HumansAnimals
    236. Sonntag W, Paulini K. [The vascularisation of the granulation tissue in different ages. - Its importance for wound healing (author's transl)]. Aktuelle Gerontol. 1977 May; 7(5):253-6. PMID: 18038.
      Citations:    Fields:    Translation:Animals
    237. Paulini K, Bock G, Sonntag W. The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma. Arzneimittelforschung. 1977; 27(11):2051-5. PMID: 579999.
      Citations:    Fields:    Translation:AnimalsCells
    238. Paulini K, Bock G, Sonntag W. The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma. Arzneimittelforschung. 1977; 27(12):2283-6. PMID: 580041.
      Citations:    Fields:    Translation:Animals
    239. Paulini K, Körner B, Mohr W, Sonntag W. The effect of complete Freund--adjuvant on chronic proliferating inflammation in an experimental granuloma model. Z Rheumatol. 1976 Mar-Apr; 35(3-4):123-31. PMID: 1266421.
      Citations: 4     Fields:    Translation:AnimalsCells
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