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Blaine H Mooers

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBRC 466
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-8300
Fax0
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    Collapse Research 
    Collapse research activities and funding
    R01AI088011     (MOOERS, BLAINE H. M.)Jul 1, 2012 - Jun 30, 2017
    NIH
    The role of non-canonical base pairs in RNA editing
    Role: Principal Investigator

    R01CA242845     (WU, JIE)Sep 1, 2020 - May 31, 2025
    NIH
    Blocking tumor progression in therapy-responsive RET aberration-associated cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shen T, Hu X, Liu X, Subbiah V, Mooers BHM, Wu J. The L730V/I RET roof mutations display different activities toward pralsetinib and selpercatinib. NPJ Precis Oncol. 2021 Jun 07; 5(1):48. PMID: 34099825.
      Citations:    
    2. Subbiah V, Shen T, Tetzlaff M, Weissferdt A, Byers LA, Cascone T, Behrang A, Meric-Bernstam F, Mooers BHM, Rothenberg SM, Ebata K, Wu J. Patient-driven discovery and post-clinical validation of NTRK3 fusion as an acquired resistance mechanism to selpercatinib in RET fusion-positive lung cancer. Ann Oncol. 2021 06; 32(6):817-819. PMID: 33617938.
      Citations:    Fields:    Translation:Humans
    3. Mooers BHM. A PyMOL snippet library for Jupyter to boost researcher productivity. Comput Sci Eng. 2021 Mar-Apr; 23(2):47-53. PMID: 33967632.
      Citations:    
    4. Mooers BHM, Brown ME. Templates for writing PyMOL scripts. Protein Sci. 2021 01; 30(1):262-269. PMID: 33179363.
      Citations: 2     Fields:    
    5. Subbiah V, Shen T, Terzyan SS, Liu X, Hu X, Patel KP, Hu M, Cabanillas M, Behrang A, Meric-Bernstam F, Vo PTT, Mooers BHM, Wu J. Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol. 2021 02; 32(2):261-268. PMID: 33161056.
      Citations: 2     Fields:    Translation:Humans
    6. Xu YF, Xu X, Gin A, Nshimiyimana JD, Mooers BHM, Caputi M, Hannafon BN, Ding WQ. SRSF1 regulates exosome microRNA enrichment in human cancer cells. Cell Commun Signal. 2020 08 20; 18(1):130. PMID: 32819370.
      Citations: 1     Fields:    
    7. Mooers BHM. Shortcuts for faster image creation in PyMOL. Protein Sci. 2020 01; 29(1):268-276. PMID: 31710740.
      Citations: 6     Fields:    Translation:Cells
    8. Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437. PMID: 31118272.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    9. Kumar V, Doharey PK, Gulati S, Meehan J, Martinez MG, Hughes K, Mooers BHM, Cruz-Reyes J. Protein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomes. PLoS One. 2019; 14(4):e0211525. PMID: 31034523.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Cruz-Reyes J, Mooers BHM, Doharey PK, Meehan J, Gulati S. Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing. Wiley Interdiscip Rev RNA. 2018 11; 9(6):e1502. PMID: 30101566.
      Citations: 9     Fields:    Translation:AnimalsCells
    11. Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Drug resistance profiles of mutations in the RET kinase domain. Br J Pharmacol. 2018 09; 175(17):3504-3515. PMID: 29908090.
      Citations: 16     Fields:    Translation:Humans
    12. Mooers BH. Simplifying and enhancing the use of PyMOL with horizontal scripts. Protein Sci. 2016 10; 25(10):1873-82. PMID: 27488983.
      Citations: 6     Fields:    
    13. Cruz-Reyes J, Mooers BH, Abu-Adas Z, Kumar V, Gulati S. DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. RNA Dis. 2016; 3(2). PMID: 27540585.
      Citations:    
    14. Mooers BH. Direct-methods structure determination of a trypanosome RNA-editing substrate fragment with translational pseudosymmetry. Acta Crystallogr D Struct Biol. 2016 Apr; 72(Pt 4):477-87. PMID: 27050127.
      Citations:    
    15. Kumar V, Madina BR, Gulati S, Vashisht AA, Kanyumbu C, Pieters B, Shakir A, Wohlschlegel JA, Read LK, Mooers BHM, Cruz-Reyes J. REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes. J Biol Chem. 2016 Mar 11; 291(11):5753-5764. PMID: 26769962.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Gu X, Mooers BH, Thomas LM, Malone J, Harris S, Schroeder SJ. Structures and Energetics of Four Adjacent G·U Pairs That Stabilize an RNA Helix. J Phys Chem B. 2015 Oct 22; 119(42):13252-61. PMID: 26425937.
      Citations: 3     Fields:    Translation:Cells
    17. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
      Citations: 8     Fields:    Translation:HumansCells
    18. Madina BR, Kumar V, Mooers BH, Cruz-Reyes J. Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing. PLoS One. 2015; 10(4):e0123441. PMID: 25928631.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Criswell A, Mooers BH. Structural studies of a double-stranded RNA from trypanosome RNA editing by small-angle X-ray scattering. Methods Mol Biol. 2015; 1240:165-89. PMID: 25352145.
      Citations:    Fields:    Translation:AnimalsCells
    20. Mooers BH. Fusion RNAs in crystallographic studies of double-stranded RNA from trypanosome RNA editing. Methods Mol Biol. 2015; 1240:191-216. PMID: 25352146.
      Citations:    Fields:    Translation:AnimalsCells
    21. Madina BR, Kumar V, Metz R, Mooers BH, Bundschuh R, Cruz-Reyes J. Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition. RNA. 2014 Jul; 20(7):1142-52. PMID: 24865612.
      Citations: 19     Fields:    Translation:AnimalsCells
    22. Ding J, Mooers BHM, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-11896. PMID: 24616095.
      Citations: 29     Fields:    Translation:Cells
    23. Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM. Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry. 2014 Mar 18; 53(10):1657-69. PMID: 24506136.
      Citations: 16     Fields:    Translation:AnimalsCells
    24. West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13. PMID: 24047895.
      Citations: 18     Fields:    Translation:HumansCells
    25. Venkatramani L, Johnson ES, Kolavi G, Air GM, Brouillette WJ, Mooers BH. Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6. BMC Struct Biol. 2012 May 06; 12:7. PMID: 22559154.
      Citations: 3     Fields:    Translation:AnimalsCells
    26. Mooers BH, Singh A. The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate. RNA. 2011 Oct; 17(10):1870-83. PMID: 21878548.
      Citations: 5     Fields:    Translation:AnimalsCells
    27. Mooers BH, Tronrud DE, Matthews BW. Evaluation at atomic resolution of the role of strain in destabilizing the temperature-sensitive T4 lysozyme mutant Arg 96 --> His. Protein Sci. 2009 May; 18(5):863-70. PMID: 19384984.
      Citations: 6     Fields:    Translation:Cells
    28. Mooers BH, Baase WA, Wray JW, Matthews BW. Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme. Protein Sci. 2009 May; 18(5):871-80. PMID: 19384988.
      Citations: 8     Fields:    Translation:Cells
    29. Mooers BH. Crystallographic studies of DNA and RNA. Methods. 2009 Mar; 47(3):168-76. PMID: 18848992.
      Citations: 9     Fields:    Translation:HumansCells
    30. Mooers BH, Matthews BW. Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. Acta Crystallogr D Biol Crystallogr. 2006 Feb; 62(Pt 2):165-76. PMID: 16421448.
      Citations: 9     Fields:    Translation:Cells
    31. Mooers BH, Logue JS, Berglund JA. The structural basis of myotonic dystrophy from the crystal structure of CUG repeats. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16626-31. PMID: 16269545.
      Citations: 75     Fields:    Translation:Cells
    32. Mooers BH, Matthews BW. Use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1726-37. PMID: 15388918.
      Citations: 6     Fields:    Translation:Cells
    33. Sagermann M, Baase WA, Mooers BH, Gay L, Matthews BW. Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. Biochemistry. 2004 Feb 10; 43(5):1296-301. PMID: 14756565.
      Citations: 6     Fields:    Translation:Cells
    34. Mooers BH, Datta D, Baase WA, Zollars ES, Mayo SL, Matthews BW. Repacking the Core of T4 lysozyme by automated design. J Mol Biol. 2003 Sep 19; 332(3):741-56. PMID: 12963380.
      Citations: 15     Fields:    Translation:Cells
    35. Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW. Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys Chem. 2003; 100(1-3):325-40. PMID: 12646375.
      Citations: 10     Fields:    Translation:Cells
    36. Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS. The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. J Mol Biol. 2001 Apr 20; 308(1):15-26. PMID: 11302703.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Eichman BF, Vargason JM, Mooers BH, Ho PS. The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3971-6. PMID: 10760268.
      Citations: 66     Fields:    Translation:Cells
    38. Mooers BH, Eichman BF, Ho PS. The structures and relative stabilities of d(G x G) reverse Hoogsteen, d(G x T) reverse wobble, and d(G x C) reverse Watson-Crick base-pairs in DNA crystals. J Mol Biol. 1997 Jun 27; 269(5):796-810. PMID: 9223642.
      Citations: 4     Fields:    Translation:Cells
    39. Ho PS, Mooers BH. Z-DNA crystallography . Biopolymers. 1997; 14(1):65-90. PMID: 19174848.
      Citations: 10     Fields:    Translation:Cells
    40. Mooers BH, Schroth GP, Baxter WW, Ho PS. Alternating and non-alternating dG-dC hexanucleotides crystallize as canonical A-DNA. J Mol Biol. 1995 Jun 16; 249(4):772-84. PMID: 7602589.
      Citations: 13     Fields:    Translation:Cells
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