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Jacob Friedman

TitleProv,Asoc Vc Diabetes Prog HSC
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentHarold Hamm Diabetes Ctr
AddressHHDC 1202
1000 N Lincoln Blvd
Oklahoma City OK 73104
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    R01DK128416     (FRIEDMAN, JACOB E)Sep 30, 2021 - Jul 31, 2025
    NIH
    Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non Human Primates
    Role: Principal Investigator
    R01DK128187     (AAGAARD, KJERSTI MARIE)Sep 17, 2021 - Jul 31, 2026
    NIH
    Metformin in Pregnancy: Fetal Consequences & Long-term Offspring Outcomes in a NHP Model
    Role: Co-Principal Investigator
    R01DK121951     (FRIEDMAN, JACOB E)Jul 1, 2020 - Jun 30, 2024
    NIH
    Role of the Macrophage in Developmentally Programmed NAFLD
    Role: Principal Investigator
    R56DK114711     (FRIEDMAN, JACOB E)Sep 7, 2018 - Aug 31, 2020
    NIH
    Discerning the influence of maternal obesity, weight gain, and diet on the infant microbiota and programming of NAFLD
    Role: Principal Investigator
    R24DK090964     (FRIEDMAN, JACOB E)Sep 25, 2010 - Jul 31, 2021
    NIH
    Interrupting the Vicious Cycle of Obesity and Metabolic Syndrome
    Role: Principal Investigator
    R21DK088324     (BARBOUR, LINDA ANNE)Apr 20, 2010 - Mar 31, 2013
    NIH
    Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes
    Role: Co-Principal Investigator
    R01DK078590     (FRIEDMAN, JACOB E)Jul 9, 2007 - Jun 30, 2012
    NIH
    MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE (NHP)
    Role: Principal Investigator
    R01DK062155     (FRIEDMAN, JACOB E)Apr 1, 2003 - Aug 31, 2007
    NIH
    Mechanisms of Insulin Resistance in GDM
    Role: Principal Investigator
    R01DK059767     (FRIEDMAN, JACOB E)Sep 15, 2000 - Jun 30, 2012
    NIH
    Regulation of glucose homeostasis by C/EBPB
    Role: Principal Investigator
    R29DK050272     (FRIEDMAN, JACOB E)Jul 1, 1996 - Jun 30, 2001
    NIH
    REGULATION OF GLUCONEOGENESIS IN EXERCISE AND DIABETES
    Role: Principal Investigator
    F32DK008477     (FRIEDMAN, JACOB E)Sep 1, 1990
    NIH
    REGULATION OF GLUCOSE TRANSPORTERS IN OBESITY &NIDDM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang L, Jonscher KR, Zhang Z, Xiong Y, Mueller RS, Friedman JE, Pan C. Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes. Nat Commun. 2022 06 21; 13(1):3551. PMID: 35729161.
      Citations: 5     Fields:    Translation:Humans
    2. Perng W, Friedman JE, Janssen RC, Glueck DH, Dabelea D. Endotoxin Biomarkers Are Associated With Adiposity and Cardiometabolic Risk Across 6 Years of Follow-up in Youth. J Clin Endocrinol Metab. 2022 06 16; 107(7):e3018-e3028. PMID: 35276001.
      Citations: 3     Fields:    Translation:Humans
    3. Mandala A, Dobrinskikh E, Janssen RC, Fiehn O, D'Alessandro A, Friedman JE, Jonscher KR. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. Int J Mol Sci. 2022 May 27; 23(11). PMID: 35682720.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. Chen C, Gu L, Matye DJ, Clayton YD, Hasan MN, Wang Y, Friedman JE, Li T. Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). PMID: 35115401.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Nash MJ, Dobrinskikh E, Newsom SA, Messaoudi I, Janssen RC, Aagaard KM, McCurdy CE, Gannon M, Kievit P, Friedman JE, Wesolowski SR. Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring. JCI Insight. 2021 12 22; 6(24). PMID: 34935645.
      Citations: 9     Fields:    Translation:AnimalsPHPublic Health
    6. Matye DJ, Wang H, Luo W, Sharp RR, Chen C, Gu L, Jones KL, Ding WX, Friedman JE, Li T. Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2021; 12(3):1001-1019. PMID: 33965587.
      Citations: 8     Fields:    Translation:AnimalsCells
    7. Soderborg TK, Carpenter CM, Janssen RC, Weir TL, Robertson CE, Ir D, Young BE, Krebs NF, Hernandez TL, Barbour LA, Frank DN, Kroehl M, Friedman JE. Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota. Front Endocrinol (Lausanne). 2020; 11:603021. PMID: 33329403.
      Citations: 34     Fields:    Translation:HumansCells
    8. Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 12; 25(4):367-387. PMID: 33216249.
      Citations: 29     Fields:    Translation:HumansCells
    9. Mandala A, Janssen RC, Palle S, Short KR, Friedman JE. Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms. Nutrients. 2020 Oct 16; 12(10). PMID: 33081177.
      Citations: 21     Fields:    Translation:HumansCells
    10. Rughani A, Friedman JE, Tryggestad JB. Type 2 Diabetes in Youth: the Role of Early Life Exposures. Curr Diab Rep. 2020 08 07; 20(9):45. PMID: 32767148.
      Citations: 14     Fields:    Translation:Humans
    11. Boyle KE, Magill-Collins MJ, Newsom SA, Janssen RC, Friedman JE. Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet. Nutrients. 2020 Mar 14; 12(3). PMID: 32183350.
      Citations: 4     Fields:    Translation:AnimalsPHPublic Health
    12. Griffin TM, Friedman JE. How can parental obesity promote OA across generations? Nat Rev Rheumatol. 2020 03; 16(3):129-130. PMID: 31949286.
      Citations:    Fields:    Translation:HumansAnimals
    13. Jonscher KR, Abrams J, Friedman JE. Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD. J Cell Immunol. 2020; 2(6):315-325. PMID: 33426540.
      Citations: 3     
    14. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
      Citations: 1     Fields:    
    15. Prince AL, Pace RM, Dean T, Takahashi D, Kievit P, Friedman JE, Aagaard KM. The development and ecology of the Japanese macaque gut microbiome from weaning to early adolescence in association with diet. Am J Primatol. 2019 10; 81(10-11):e22980. PMID: 31066111.
      Citations: 14     Fields:    Translation:AnimalsCells
    16. Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 05 01; 316(5):R427-R440. PMID: 30758974.
      Citations: 20     Fields:    Translation:AnimalsCells
    17. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
      Citations: 118     Fields:    Translation:HumansAnimals
    18. Wesolowski SR, Mulligan CM, Janssen RC, Baker PR, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 12; 18:25-41. PMID: 30337225.
      Citations: 26     Fields:    Translation:AnimalsCells
    19. Borengasser SJ, Baker PR, Kerns ME, Miller LV, Palacios AP, Kemp JF, Westcott JE, Morrison SD, Hernandez TL, Garces A, Figueroa L, Friedman JE, Hambidge KM, Krebs NF. Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese. Nutrients. 2018 Sep 11; 10(9). PMID: 30208589.
      Citations: 4     Fields:    Translation:HumansCells
    20. Baker PR, Friedman JE. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest. 2018 08 31; 128(9):3692-3703. PMID: 30168806.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    21. Pace RM, Prince AL, Ma J, Belfort BDW, Harvey AS, Hu M, Baquero K, Blundell P, Takahashi D, Dean T, Kievit P, Sullivan EL, Friedman JE, Grove K, Aagaard KM. Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates. BMC Microbiol. 2018 04 05; 18(1):28. PMID: 29621980.
      Citations: 13     Fields:    Translation:AnimalsCells
    22. Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta. 2018 04; 64:53-60. PMID: 29626981.
      Citations: 25     Fields:    Translation:Humans
    23. Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018 03; 2(3):313-328. PMID: 29507905.
      Citations: 25     Fields:    
    24. Baker PR, Patinkin ZW, Shapiro ALB, de la Houssaye BA, Janssen RC, Vanderlinden LA, Dabelea D, Friedman JE. Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. Sci Rep. 2017 12 22; 7(1):18095. PMID: 29273781.
      Citations: 14     Fields:    Translation:HumansCells
    25. Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS. Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes. 2018 04; 67(4):651-661. PMID: 29138256.
      Citations: 21     Fields:    Translation:AnimalsCells
    26. Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017 11; 6(11):1503-1516. PMID: 29107296.
      Citations: 33     Fields:    Translation:HumansCells
    27. Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 01; 105(1):234-236. PMID: 28049665.
      Citations:    Fields:    
    28. Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2017 04; 31(4):1434-1448. PMID: 28007783.
      Citations: 31     Fields:    Translation:Animals
    29. Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 11 04; 6:36123. PMID: 27811965.
      Citations: 22     Fields:    Translation:Animals
    30. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):81-96. PMID: 27780972.
      Citations: 100     Fields:    Translation:HumansCells
    31. McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612. PMID: 27734025.
      Citations: 46     Fields:    Translation:AnimalsCells
    32. Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2017 Jan; 49(1):50-57. PMID: 28103623.
      Citations: 7     Fields:    Translation:HumansCells
    33. Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016; 11(5):e0155282. PMID: 27145222.
      Citations: 3     Fields:    
    34. Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016; 11(4):e0152877. PMID: 27097220.
      Citations: 40     Fields:    Translation:AnimalsCells
    35. Rahman SM, Baquero KC, Choudhury M, Janssen RC, de la Houssaye BA, Sun M, Miyazaki-Anzai S, Wang S, Moustaid-Moussa N, Miyazaki M, Friedman JE. C/EBPß in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis. Atherosclerosis. 2016 07; 250:172-9. PMID: 27072340.
      Citations: 12     Fields:    Translation:AnimalsCells
    36. Friedman JE. Obesity and Gestational Diabetes Mellitus Pathways for Programming in Mouse, Monkey, and Man—Where Do We Go Next? The 2014 Norbert Freinkel Award Lecture. Diabetes Care. 2015 Aug; 38(8):1402-11. PMID: 26207051.
      Citations: 37     Fields:    Translation:HumansAnimals
    37. Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan; 39(1):39-42. PMID: 26223240.
      Citations: 66     Fields:    Translation:HumansPHPublic Health
    38. Baker PR, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE. Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. Obesity (Silver Spring). 2015 May; 23(5):981-988. PMID: 25864501.
      Citations: 31     Fields:    Translation:HumansCells
    39. Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One. 2014; 9(9):e106872. PMID: 25216282.
      Citations: 25     Fields:    Translation:HumansCells
    40. Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug; 63(8):2702-13. PMID: 24705404.
      Citations: 63     Fields:    Translation:AnimalsCells
    41. Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun; 28(6):2466-77. PMID: 24563374.
      Citations: 59     Fields:    Translation:Animals
    42. Brumbaugh DE, Friedman JE. Developmental origins of nonalcoholic fatty liver disease. Pediatr Res. 2014 Jan; 75(1-2):140-7. PMID: 24192698.
      Citations: 75     Fields:    Translation:HumansAnimals
    43. Stewart MS, Heerwagen MJ, Friedman JE. Developmental programming of pediatric nonalcoholic fatty liver disease: redefining the"first hit". Clin Obstet Gynecol. 2013 Sep; 56(3):577-90. PMID: 23835912.
      Citations: 12     Fields:    Translation:HumansCells
    44. Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013 Oct; 98(10):E1601-9. PMID: 23956348.
      Citations: 31     Fields:    Translation:HumansCells
    45. Heerwagen MJ, Stewart MS, de la Houssaye BA, Janssen RC, Friedman JE. Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice. PLoS One. 2013; 8(6):e67791. PMID: 23825686.
      Citations: 56     Fields:    Translation:HumansAnimals
    46. Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013 May; 162(5):930-6.e1. PMID: 23260099.
      Citations: 99     Fields:    Translation:Humans
    47. Rahman SM, Choudhury M, Janssen RC, Baquero KC, Miyazaki M, Friedman JE. CCAAT/enhancer binding protein ß deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis. Biochem Biophys Res Commun. 2013 Jan 04; 430(1):336-9. PMID: 23159614.
      Citations: 4     Fields:    Translation:AnimalsCells
    48. Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012; 7(10):e48119. PMID: 23118937.
      Citations: 24     Fields:    Translation:AnimalsCells
    49. Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012 Dec; 26(12):5106-14. PMID: 22982377.
      Citations: 86     Fields:    Translation:AnimalsCells
    50. Qadri I, Choudhury M, Rahman SM, Knotts TA, Janssen RC, Schaack J, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, Friedman JE. Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein ß. J Biol Chem. 2012 Oct 26; 287(44):37340-51. PMID: 22955269.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    51. Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, Friedman JE. CCAAT/enhancer-binding protein ß (C/EBPß) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice. J Biol Chem. 2012 Oct 05; 287(41):34349-60. PMID: 22902781.
      Citations: 60     Fields:    Translation:AnimalsCells
    52. Hernandez TL, Friedman JE, Van Pelt RE, Barbour LA. Patterns of glycemia in normal pregnancy: should the current therapeutic targets be challenged? Diabetes Care. 2011 Jul; 34(7):1660-8. PMID: 21709299.
      Citations: 51     Fields:    Translation:Humans
    53. Attia RR, Sharma P, Janssen RC, Friedman JE, Deng X, Lee JS, Elam MB, Cook GA, Park EA. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta). J Biol Chem. 2011 Jul 08; 286(27):23799-807. PMID: 21586575.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    54. Grant WF, Gillingham MB, Batra AK, Fewkes NM, Comstock SM, Takahashi D, Braun TP, Grove KL, Friedman JE, Marks DL. Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS One. 2011 Feb 25; 6(2):e17261. PMID: 21364873.
      Citations: 59     Fields:    Translation:HumansAnimals
    55. Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J. 2011 Feb 01; 433(3):505-14. PMID: 21044047.
      Citations: 192     Fields:    Translation:AnimalsCells
    56. Choudhury M, Jonscher KR, Friedman JE. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging (Albany NY). 2011 Feb; 3(2):175-8. PMID: 21386135.
      Citations: 45     Fields:    Translation:AnimalsCells
    57. Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE. C/EBPß is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells. Mol Cell Endocrinol. 2011 Jan 01; 331(1):102-8. PMID: 20797423.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    58. Majka SM, Fox KE, Psilas JC, Helm KM, Childs CR, Acosta AS, Janssen RC, Friedman JE, Woessner BT, Shade TR, Varella-Garcia M, Klemm DJ. De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14781-6. PMID: 20679227.
      Citations: 78     Fields:    Translation:AnimalsCells
    59. Rahman SM, Qadri I, Janssen RC, Friedman JE. Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. J Lipid Res. 2009 Nov; 50(11):2193-202. PMID: 19502591.
      Citations: 17     Fields:    Translation:HumansCells
    60. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452.
      Citations: 94     Fields:    Translation:AnimalsCells
    61. McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest. 2009 Feb; 119(2):323-35. PMID: 19147984.
      Citations: 323     Fields:    Translation:AnimalsCells
    62. Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes. 2009 Jan; 58(1):116-24. PMID: 18952837.
      Citations: 60     Fields:    Translation:AnimalsCells
    63. Friedman JE, Kirwan JP, Jing M, Presley L, Catalano PM. Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum. Diabetes. 2008 Mar; 57(3):606-13. PMID: 18083784.
      Citations: 32     Fields:    Translation:HumansCells
    64. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789.
      Citations: 32     Fields:    Translation:AnimalsCells
    65. Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology. 2007 May; 45(5):1108-17. PMID: 17464987.
      Citations: 65     Fields:    Translation:AnimalsCells
    66. Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem. 2007 May 25; 282(21):15717-29. PMID: 17387171.
      Citations: 55     Fields:    Translation:AnimalsCells
    67. Barry JS, Davidsen ML, Limesand SW, Galan HL, Friedman JE, Regnault TR, Hay WW. Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction. Exp Biol Med (Maywood). 2006 May; 231(5):566-75. PMID: 16636305.
      Citations: 19     Fields:    Translation:AnimalsCells
    68. Velliquette RA, Friedman JE, Shao J, Zhang BB, Ernsberger P. Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X. J Pharmacol Exp Ther. 2005 Jul; 314(1):422-30. PMID: 15833894.
      Citations: 3     Fields:    Translation:AnimalsCells
    69. Shao J, Qiao L, Janssen RC, Pagliassotti M, Friedman JE. Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio. Diabetes. 2005 Apr; 54(4):976-84. PMID: 15793235.
      Citations: 25     Fields:    Translation:AnimalsCells
    70. Kirwan JP, Varastehpour A, Jing M, Presley L, Shao J, Friedman JE, Catalano PM. Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling. J Clin Endocrinol Metab. 2004 Sep; 89(9):4678-84. PMID: 15356080.
      Citations: 37     Fields:    Translation:HumansCells
    71. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004 Mar; 145(3):1144-50. PMID: 14633976.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    72. Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003 Mar; 53(3):411-8. PMID: 12595588.
      Citations: 34     Fields:    Translation:AnimalsCells
    73. Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, Friedman JE. Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem. 2002 Jun 28; 277(26):23301-7. PMID: 11964395.
      Citations: 58     Fields:    Translation:AnimalsCells
    74. Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E522-33. PMID: 11832353.
      Citations: 81     Fields:    Translation:Humans
    75. Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes. 2002 Jan; 51(1):19-29. PMID: 11756318.
      Citations: 22     Fields:    Translation:AnimalsCells
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