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Robert H Cichewicz

TitleProfessor
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Address620 Parrington Oval
Norman OK 73019
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    Collapse Research 
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    R21NS064313     (CICHEWICZ, ROBERT HENRY)May 1, 2009 - Apr 30, 2011
    NIH
    Translating Natural Products into Therapeutic Leads for Huntington's Disease
    Role: Principal Investigator

    R01AI085161     (CICHEWICZ, ROBERT HENRY)Jan 15, 2010 - Dec 31, 2015
    NIH
    Chemically diverse antimicrobials from silent biosynthetic pathways
    Role: Principal Investigator

    R01GM092219     (CICHEWICZ, ROBERT HENRY)Aug 15, 2010 - May 31, 2014
    NIH
    Accessing Natural Products from Silent Biosynthetic Pathways
    Role: Principal Investigator

    R21AI101487     (CICHEWICZ, ROBERT HENRY)Jul 15, 2012 - Mar 30, 2015
    NIH
    Antimicrobials from Mammalian Microbiomes
    Role: Principal Investigator

    R01GM107490     (CICHEWICZ, ROBERT HENRY)Jul 1, 2014 - Apr 30, 2019
    NIH
    Sourcing Bioactive Secondary Metabolites from Great Lakes Fungi
    Role: Principal Investigator

    U01CA182740     (MOOBERRY, SUSAN L)Sep 22, 2014 - Aug 31, 2020
    NIH
    New Leads for Triple Negative Breast Cancer from Diverse Natural Sources
    Role: Co-Principal Investigator

    R21AI115390     (CICHEWICZ, ROBERT HENRY)May 15, 2015 - Apr 30, 2017
    NIH
    Procuring Native Natural Product Producers by In Situ Chimera Assembly
    Role: Principal Investigator

    R21AI119713     (CICHEWICZ, ROBERT HENRY)Jun 12, 2015 - May 31, 2017
    NIH
    Early Stage Discovery of Natural Products Targeting Anaerobic Protozoal Pathogen
    Role: Principal Investigator

    R33AI119713     (CICHEWICZ, ROBERT HENRY)Jun 12, 2015 - May 31, 2021
    NIH
    Early Stage Discovery of Natural Products Targeting Anaerobic Protozoal Pathogen
    Role: Principal Investigator

    R21AI126068     (ROHDE, KYLE H)Jan 20, 2017 - Dec 31, 2019
    NIH
    Exploiting Fungal Natural Products to Discover Novel Scaffolds That Inhibit Dormant and Drug-Resistant TB
    Role: Co-Principal Investigator

    R21AI143052     (CHAKRABARTI, DEBOPAM)Nov 25, 2018 - Oct 31, 2021
    NIH
    Discovery of Novel Antimalarial Compounds from Fungi
    Role: Co-Principal Investigator

    R01AI154777     (CHAKRABARTI, DEBOPAM)May 18, 2020 - Apr 30, 2025
    NIH
    Novel Antimalarials from Fungi
    Role: Co-Principal Investigator

    R21AI153863     (CICHEWICZ, ROBERT HENRY)Nov 25, 2020 - Oct 31, 2022
    NIH
    Fungal natural products targeting antimicrobial resistant Mycoplasma genitalium
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee JW, Collins JE, Wendt KL, Chakrabarti D, Cichewicz RH. Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics. J Nat Prod. 2021 02 26; 84(2):503-517. PMID: 33565879.
      Citations:    Fields:    
    2. Ma H, Liang H, Cai S, O'Keefe BR, Mooberry SL, Cichewicz RH. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. J Nat Prod. 2021 03 26; 84(3):750-761. PMID: 33226219.
      Citations:    Fields:    
    3. Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. J Nat Prod. 2020 10 23; 83(10):3080-3092. PMID: 33021790.
      Citations:    Fields:    
    4. Scull EM, Bandari C, Johnson BP, Gardner ED, Tonelli M, You J, Cichewicz RH, Singh S. Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains. Appl Microbiol Biotechnol. 2020 Sep; 104(18):7853-7865. PMID: 32725322.
      Citations: 1     Fields:    Translation:Cells
    5. Pederson PJ, Cai S, Carver C, Powell DR, Risinger AL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. J Nat Prod. 2020 07 24; 83(7):2269-2280. PMID: 32649211.
      Citations:    Fields:    
    6. Kil YS, Risinger AL, Petersen CL, Mooberry SL, Cichewicz RH. Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer. J Nat Prod. 2020 06 26; 83(6):2010-2024. PMID: 32510949.
      Citations:    Fields:    
    7. Nguyen TD, Lesani M, Forrest I, Lan Y, Dean DA, Gibaut QMR, Guo Y, Hossain E, Olvera M, Panlilio H, Parab AR, Wu C, Bernatchez JA, Cichewicz RH, McCall LI. Local Phenomena Shape Backyard Soil Metabolite Composition. Metabolites. 2020 Feb 29; 10(3). PMID: 32121389.
      Citations:    
    8. Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris. J Nat Prod. 2020 03 27; 83(3):584-592. PMID: 32105068.
      Citations: 1     Fields:    
    9. Tran TD, Wilson BAP, Henrich CJ, Wendt KL, King J, Cichewicz RH, Stchigel AM, Miller AN, O'Keefe BR, Gustafson KR. Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry. 2020 May; 173:112278. PMID: 32078832.
      Citations:    Fields:    Translation:AnimalsCells
    10. Dai W, Sandoval IT, Cai S, Smith KA, Delacruz RGC, Boyd KA, Mills JJ, Jones DA, Cichewicz RH. Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay. J Nat Prod. 2019 09 27; 82(9):2627-2637. PMID: 31433188.
      Citations:    Fields:    Translation:Animals
    11. Du L, Munteanu C, King JB, Frantz DE, Cichewicz RH. An Electrophilic Natural Product Provides a Safe and Robust Odor Neutralization Approach To Counteract Malodorous Organosulfur Metabolites Encountered in Skunk Spray. J Nat Prod. 2019 07 26; 82(7):1989-1999. PMID: 31273979.
      Citations:    Fields:    Translation:Animals
    12. King JB, Carter AC, Dai W, Lee JW, Kil YS, Du L, Helff SK, Cai S, Huddle BC, Cichewicz RH. Design and Application of a High-Throughput, High-Content Screening System for Natural Product Inhibitors of the Human Parasite Trichomonas vaginalis. ACS Infect Dis. 2019 08 09; 5(8):1456-1470. PMID: 31265248.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Carter AC, King JB, Mattes AO, Cai S, Singh N, Cichewicz RH. Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B1. J Nat Prod. 2019 06 28; 82(6):1694-1703. PMID: 31136174.
      Citations:    Fields:    Translation:HumansCells
    14. Carter AC, Petersen CL, Wendt KL, Helff SK, Risinger AL, Mooberry SL, Cichewicz RH. In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway. J Nat Prod. 2019 04 26; 82(4):886-894. PMID: 30865445.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines. J Nat Prod. 2019 04 26; 82(4):928-936. PMID: 30830773.
      Citations: 1     Fields:    Translation:HumansCells
    16. Du L, Risinger AL, Yee SS, Ola ARB, Zammiello CL, Cichewicz RH, Mooberry SL. Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers. J Nat Prod. 2019 03 22; 82(3):583-588. PMID: 30799622.
      Citations: 4     Fields:    Translation:HumansCells
    17. Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities. J Nat Prod. 2019 01 25; 82(1):154-162. PMID: 30600998.
      Citations: 6     Fields:    Translation:Animals
    18. Ola ARB, Risinger AL, Du L, Zammiello CL, Peng J, Cichewicz RH, Mooberry SL. Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25. J Nat Prod. 2018 03 23; 81(3):579-593. PMID: 29360362.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Wahl HE, Raudabaugh DB, Bach EM, Bone TS, Luttenton MR, Cichewicz RH, Miller AN. What lies beneath? Fungal diversity at the bottom of Lake Michigan and Lake Superior. J Great Lakes Res. 2018 Apr; 44(2):263-270. PMID: 29736110.
      Citations:    
    20. Robles AJ, McCowen S, Cai S, Glassman M, Ruiz F, Cichewicz RH, McHardy SF, Mooberry SL. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 11 22; 60(22):9275-9289. PMID: 29053266.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Du L, Risinger AL, Mitchell CA, You J, Stamps BW, Pan N, King JB, Bopassa JC, Judge SIV, Yang Z, Stevenson BS, Cichewicz RH. Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E8957-E8966. PMID: 29073092.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Graef JL, Rendina-Ruedy E, Crockett EK, Ouyang P, King JB, Cichewicz RH, Lucas EA, Smith BJ. Select polyphenolic fractions from dried plum enhance osteoblast activity through BMP-2 signaling. J Nutr Biochem. 2018 05; 55:59-67. PMID: 29413490.
      Citations: 5     Fields:    Translation:AnimalsCells
    23. Graef JL, Rendina-Ruedy E, Crockett EK, Ouyang P, Wu L, King JB, Cichewicz RH, Lin D, Lucas EA, Smith BJ. Osteoclast Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells. Curr Dev Nutr. 2017 Oct; 1(10):e000406. PMID: 29955675.
      Citations:    
    24. Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz M, Beutler JA. Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. J Nat Prod. 2017 07 28; 80(7):2037-2044. PMID: 28654255.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    25. Cichewicz RH, Cragg GM, Linington RG, Wright AE. Special Issue in Honor of Professor Phil Crews. J Nat Prod. 2017 03 24; 80(3):579-581. PMID: 28335607.
      Citations:    Fields:    Translation:HumansAnimals
    26. Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH. Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes. J Nat Prod. 2017 04 28; 80(4):1233. PMID: 28339197.
      Citations:    Fields:    
    27. Risinger AL, Li J, Du L, Benavides R, Robles AJ, Cichewicz RH, Kuhn JG, Mooberry SL. Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ. J Nat Prod. 2017 02 24; 80(2):409-414. PMID: 28112516.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    28. Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 Nov-Dec; 1(6). PMID: 28028548.
      Citations:    
    29. Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH. Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes. J Nat Prod. 2017 03 24; 80(3):598-608. PMID: 28335605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. Robles AJ, Du L, Cichewicz RH, Mooberry SL. Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer. J Nat Prod. 2016 07 22; 79(7):1822-7. PMID: 27310425.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    31. Robles AJ, Cai S, Cichewicz RH, Mooberry SL. Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer. Breast Cancer Res Treat. 2016 06; 157(3):475-88. PMID: 27255535.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    32. Foxley MA, Friedline AW, Jensen JM, Nimmo SL, Scull EM, King JB, Strange S, Xiao MT, Smith BE, Thomas Iii KJ, Glatzhofer DT, Cichewicz RH, Rice CV. Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine). J Antibiot (Tokyo). 2016 Dec; 69(12):871-878. PMID: 27189119.
      Citations: 9     Fields:    Translation:Cells
    33. Van Kanegan MJ, Dunn DE, Kaltenbach LS, Shah B, He DN, McCoy DD, Yang P, Peng J, Shen L, Du L, Cichewicz RH, Newman RA, Lo DC. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Sci Rep. 2016 05 12; 6:25626. PMID: 27172999.
      Citations: 8     Fields:    Translation:HumansAnimals
    34. Du L, You J, Nicholas KM, Cichewicz RH. Chemoreactive Natural Products that Afford Resistance Against Disparate Antibiotics and Toxins. Angew Chem Int Ed Engl. 2016 Mar 18; 55(13):4220-5. PMID: 26928999.
      Citations: 2     Fields:    
    35. Shaffer CV, Cai S, Peng J, Robles AJ, Hartley RM, Powell DR, Du L, Cichewicz RH, Mooberry SL. Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells. J Nat Prod. 2016 Mar 25; 79(3):531-40. PMID: 26785306.
      Citations: 6     Fields:    Translation:HumansCells
    36. Cai S, Risinger AL, Nair S, Peng J, Anderson TJ, Du L, Powell DR, Mooberry SL, Cichewicz RH. Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants. J Nat Prod. 2016 Mar 25; 79(3):490-8. PMID: 26722868.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    37. Niu G, Wang B, Zhang G, King JB, Cichewicz RH, Li J. Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission. Sci Rep. 2015 Oct 06; 5:14694. PMID: 26437882.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. Wang B, Park EM, King JB, Mattes AO, Nimmo SL, Clendinen C, Edison AS, Anklin C, Cichewicz RH. Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production. J Nat Prod. 2015 Jun 26; 78(6):1415-21. PMID: 26061478.
      Citations: 4     Fields:    Translation:AnimalsCells
    39. Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity. Angew Chem Int Ed Engl. 2015 Jun 01; 54(23):6671. PMID: 26055200.
      Citations: 1     Fields:    
    40. Du L, King JB, Cichewicz RH. Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid. J Nat Prod. 2014 Nov 26; 77(11):2454-8. PMID: 25338315.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Wang B, You J, King JB, Cai S, Park E, Powell DR, Cichewicz RH. Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation. J Nat Prod. 2014 Oct 24; 77(10):2273-9. PMID: 25302529.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. Cai S, King JB, Du L, Powell DR, Cichewicz RH. Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample. J Nat Prod. 2014 Oct 24; 77(10):2280-7. PMID: 25265160.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Du L, Risinger AL, King JB, Powell DR, Cichewicz RH. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014 Jul 25; 77(7):1753-7. PMID: 24999749.
      Citations: 16     Fields:    Translation:HumansCells
    44. Williams RB, Du L, Norman VL, Goering MG, O'Neil-Johnson M, Woodbury S, Albrecht MA, Powell DR, Cichewicz RH, Eldridge GR, Starks CM. Diterpenes from the endangered goldenrod Solidago shortii. J Nat Prod. 2014 Jun 27; 77(6):1438-44. PMID: 24922615.
      Citations:    Fields:    Translation:AnimalsCells
    45. Du L, Robles AJ, King JB, Mooberry SL, Cichewicz RH. Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. J Nat Prod. 2014 Jun 27; 77(6):1459-66. PMID: 24893224.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    46. Theodore CM, Stamps BW, King JB, Price LS, Powell DR, Stevenson BS, Cichewicz RH. Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain. PLoS One. 2014; 9(3):e90124. PMID: 24595070.
      Citations: 8     Fields:    Translation:AnimalsCells
    47. Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angew Chem Int Ed Engl. 2014 Jan 13; 53(3):804-9. PMID: 24285637.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    48. Cai S, Du L, Gerea AL, King JB, You J, Cichewicz RH. Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus. Org Lett. 2013 Aug 16; 15(16):4186-9. PMID: 23924243.
      Citations: 6     Fields:    Translation:AnimalsCells
    49. You J, Du L, King JB, Hall BE, Cichewicz RH. Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chem Biol. 2013 Apr 19; 8(4):840-8. PMID: 23387427.
      Citations: 13     Fields:    Translation:Animals
    50. Theodore CM, King JB, You J, Cichewicz RH. Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets. J Nat Prod. 2012 Nov 26; 75(11):2007-11. PMID: 23095088.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    51. Du L, King JB, Morrow BH, Shen JK, Miller AN, Cichewicz RH. Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. J Nat Prod. 2012 Oct 26; 75(10):1819-23. PMID: 23046341.
      Citations: 11     Fields:    Translation:AnimalsCells
    52. Gerea AL, Branscum KM, King JB, You J, Powell DR, Miller AN, Spear JR, Cichewicz RH. Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring. Tetrahedron Lett. 2012 Aug 08; 53(32):4202-4205. PMID: 22844162.
      Citations: 6     Fields:    
    53. Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan W. trans-(-)-e-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Biol Chem. 2012 Jul 13; 287(29):24460-72. PMID: 22648412.
      Citations: 59     Fields:    Translation:AnimalsCells
    54. Wang X, You J, King JB, Powell DR, Cichewicz RH. Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. J Nat Prod. 2012 Apr 27; 75(4):707-15. PMID: 22400916.
      Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    55. Wang X, Du L, You J, King JB, Cichewicz RH. Fungal biofilm inhibitors from a human oral microbiome-derived bacterium. Org Biomol Chem. 2012 Mar 14; 10(10):2044-50. PMID: 22281750.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    56. Miao FP, Li XD, Liu XH, Cichewicz RH, Ji NY. Secondary metabolites from an algicolous Aspergillus versicolor strain. Mar Drugs. 2012 Jan; 10(1):131-9. PMID: 22363226.
      Citations: 14     Fields:    Translation:AnimalsCells
    57. Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med. 2011 Dec 18; 18(1):153-8. PMID: 22179319.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    58. Henrikson JC, Ellis TK, King JB, Cichewicz RH. Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems. J Nat Prod. 2011 Sep 23; 74(9):1959-64. PMID: 21854017.
      Citations: 8     Fields:    Translation:AnimalsCells
    59. Joyner PM, Waters AL, Williams RB, Powell DR, Janakiram NB, Rao CV, Cichewicz RH. Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells. J Nat Prod. 2011 Apr 25; 74(4):857-61. PMID: 21438584.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    60. Joyner PM, Cichewicz RH. Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases. Nat Prod Rep. 2011 Jan; 28(1):26-47. PMID: 20927454.
      Citations: 11     Fields:    Translation:HumansCells
    61. Joyner PM, Liu J, Zhang Z, Merritt J, Qi F, Cichewicz RH. Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Org Biomol Chem. 2010 Dec 21; 8(24):5486-9. PMID: 20852771.
      Citations: 39     Fields:    Translation:Cells
    62. Wu C, Cichewicz R, Li Y, Liu J, Roe B, Ferretti J, Merritt J, Qi F. Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance. Appl Environ Microbiol. 2010 Sep; 76(17):5815-26. PMID: 20639370.
      Citations: 37     Fields:    Translation:Cells
    63. Wang X, Sena Filho JG, Hoover AR, King JB, Ellis TK, Powell DR, Cichewicz RH. Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum. J Nat Prod. 2010 May 28; 73(5):942-8. PMID: 20450206.
      Citations: 41     Fields:    Translation:AnimalsCells
    64. Cichewicz RH, Hambright KD. A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity. Toxicon. 2010 May; 55(5):1035-7; author reply 1038-43. PMID: 20223344.
      Citations: 2     Fields:    Translation:Animals
    65. Henrikson JC, Gharfeh MS, Easton AC, Easton JD, Glenn KL, Shadfan M, Mooberry SL, Hambright KD, Cichewicz RH. Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America. Toxicon. 2010 Jun 15; 55(7):1396-404. PMID: 20184911.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    66. Cichewicz RH, Hambright KD. WITHDRAWN: A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity. Toxicon. 2010 Feb 13. PMID: 20156471.
      Citations:    Fields:    
    67. Joyner PM, Matheke RM, Smith LM, Cichewicz RH. Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice. J Proteome Res. 2010 Jan; 9(1):404-12. PMID: 19908918.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    68. Cichewicz RH. Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep. 2010 Jan; 27(1):11-22. PMID: 20024091.
      Citations: 69     Fields:    Translation:AnimalsCells
    69. Sena Filho JG, Nimmo SL, Xavier HS, Barbosa-Filho JM, Cichewicz RH. Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies. J Nat Prod. 2009 Jul; 72(7):1344-7. PMID: 19485331.
      Citations: 3     Fields:    Translation:AnimalsCells
    70. Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, W├Ągele H, Cichewicz RH. Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger. J Ind Microbiol Biotechnol. 2009 Sep; 36(9):1199-213. PMID: 19521728.
      Citations: 47     Fields:    Translation:AnimalsCells
    71. Henrikson JC, Hoover AR, Joyner PM, Cichewicz RH. A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger. Org Biomol Chem. 2009 Feb 07; 7(3):435-8. PMID: 19156306.
      Citations: 58     Fields:    Translation:Animals
    72. Amagata T, Johnson TA, Cichewicz RH, Tenney K, Mooberry SL, Media J, Edelstein M, Valeriote FA, Crews P. Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges. J Med Chem. 2008 Nov 27; 51(22):7234-42. PMID: 18942825.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    73. Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH. Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem. 2008 Jun 07; 6(11):1895-7. PMID: 18480899.
      Citations: 82     Fields:    Translation:Animals
    74. Williams RB, Gutekunst WR, Joyner PM, Duan W, Li Q, Ross CA, Williams TD, Cichewicz RH. Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity. J Agric Food Chem. 2007 Nov 14; 55(23):9450-6. PMID: 17944533.
      Citations: 5     Fields:    Translation:HumansAnimals
    75. Johnson TA, Tenney K, Cichewicz RH, Morinaka BI, White KN, Amagata T, Subramanian B, Media J, Mooberry SL, Valeriote FA, Crews P. Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties. J Med Chem. 2007 Aug 09; 50(16):3795-803. PMID: 17622130.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    76. Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorg Med Chem. 2005 Oct 01; 13(19):5600-12. PMID: 16039133.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    77. Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors. J Am Chem Soc. 2004 Nov 17; 126(45):14910-20. PMID: 15535718.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    78. Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29; 47(16):4060-5. PMID: 15267244.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    79. Zhang Y, Cichewicz RH, Nair MG. Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves. Life Sci. 2004 Jun 25; 75(6):753-63. PMID: 15172183.
      Citations: 9     Fields:    Translation:AnimalsCells
    80. Cichewicz RH, Valeriote FA, Crews P. Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family. Org Lett. 2004 Jun 10; 6(12):1951-4. PMID: 15176791.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    81. Cichewicz RH, Zhang Y, Seeram NP, Nair MG. Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies. Life Sci. 2004 Feb 20; 74(14):1791-9. PMID: 14741736.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    82. Cichewicz RH, Kouzi SA. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2004 Jan; 24(1):90-114. PMID: 14595673.
      Citations: 71     Fields:    Translation:HumansAnimals
    83. Seeram NP, Cichewicz RH, Chandra A, Nair MG. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. J Agric Food Chem. 2003 Mar 26; 51(7):1948-51. PMID: 12643656.
      Citations: 7     Fields:    Translation:Animals
    84. Cichewicz RH, Nair MG. Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (hemerocallis) flowers. J Agric Food Chem. 2002 Jan 02; 50(1):87-91. PMID: 11754548.
      Citations: 10     Fields:    Translation:Animals
    85. Cichewicz RH, Kouzi SA, Hamann MT. Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea. J Nat Prod. 2000 Jan; 63(1):29-33. PMID: 10650073.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    86. Cichewicz RH, Kouzi SA. Biotransformation of resveratrol to piceid by Bacillus cereus. J Nat Prod. 1998 Oct; 61(10):1313-4. PMID: 9784180.
      Citations: 6     Fields:    Translation:Cells
    87. Cichewicz RH, Thorpe PA. The antimicrobial properties of chile peppers (Capsicum species) and their uses in Mayan medicine. J Ethnopharmacol. 1996 Jun; 52(2):61-70. PMID: 8735449.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
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