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Richard S Brush

InstitutionUniversity of Oklahoma Health Sciences Center
AddressDMEI 401
608 Stanton L Young Blvd
Oklahoma City OK 73104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Golubkova A, Leiva T, Snyder K, Schlegel C, Bonvicino SM, Agbaga MP, Brush RS, Hansen JM, Vitiello PF, Hunter CJ. Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis. Antioxidants (Basel). 2023 Jul 05; 12(7). PMID: 37507924; PMCID: PMC10376622.
    2. Bernardo-Col?n A, Dong L, Abu-Asab M, Brush RS, Agbaga MP, Becerra SP. Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration. J Lipid Res. 2023 Mar 17; 64(5):100358. PMID: 36934843.
      Citations:    Fields:    Translation:Animals
    3. Zyla-Jackson K, Walton DA, Plafker KS, Kovats S, Georgescu C, Brush RS, Tytanic M, Agbaga MP, Plafker SM. Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis. Front Neurol. 2023; 14:1113954. PMID: 36937529; PMCID: PMC10017782.
      Citations: 1     
    4. Gavrizi SZ, Hosseinzadeh P, Brush RS, Tytanic M, Eckart E, Peck JD, Craig LB, Diamond MP, Agbaga MP, Hansen KR. Sperm very long-chain polyunsaturated fatty acids: relation to semen parameters and live birth outcome in a multicenter trial. Fertil Steril. 2023 Jan 19. PMID: 36681262.
      Citations:    Fields:    Translation:HumansCells
    5. Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A. Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism. Commun Biol. 2023 01 04; 6(1):8. PMID: 36599953; PMCID: PMC9813353.
      Citations:    Translation:AnimalsCells
    6. Hopiavuori BR, Masser DR, Wilkerson JL, Brush RS, Mandal NA, Anderson RE, Freeman WM. Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods Mol Biol. 2023; 2625:7-15. PMID: 36653629.
      Citations:    Fields:    Translation:Cells
    7. Gyening YK, Chauhan NK, Tytanic M, Ea V, Brush RS, Agbaga MP. ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis. J Lipid Res. 2023 01; 64(1):100317. PMID: 36464075; PMCID: PMC9823237.
      Citations: 2     Fields:    Translation:Humans
    8. Sugino KY, Mandala A, Janssen RC, Gurung S, Trammell M, Day MW, Brush RS, Papin JF, Dyer DW, Agbaga MP, Friedman JE, Castillo-Castrejon M, Jonscher KR, Myers DA. Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver. Front Clin Diabetes Healthc. 2022; 3. PMID: 36935840; PMCID: PMC10012127.
      Citations: 1     
    9. Liu H, Witzigreuter L, Sathiaseelan R, Agbaga MP, Brush RS, Stout MB, Zhu S. Obesity promotes lipid accumulation in mouse cartilage-A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis. J Orthop Res. 2022 Mar 12. PMID: 35279877.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Nagaraja RY, Sherry DM, Fessler JL, Stiles MA, Li F, Multani K, Orock A, Ahmad M, Brush RS, Anderson RE, Agbaga MP, Deák F. W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34. Mol Neurobiol. 2021 Oct; 58(10):4921-4943. PMID: 34227061.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Cheng SY, Malachi A, Cipi J, Ma S, Brush RS, Agbaga MP, Punzo C. HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies. Biomolecules. 2021 06 11; 11(6). PMID: 34208233.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Yeboah GK, Lobanova ES, Brush RS, Agbaga MP. Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4. J Lipid Res. 2021; 62:100030. PMID: 33556440.
      Citations: 12     Fields:    
    13. Agbaga MP, Stiles MA, Brush RS, Sullivan MT, Machalinski A, Jones KL, Anderson RE, Sherry DM. The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration. Mol Neurobiol. 2020 Nov; 57(11):4735-4753. PMID: 32780351.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Rajala A, McCauley A, Brush RS, Nguyen K, Rajala RVS. Phosphoinositide Lipids in Ocular Tissues. Biology (Basel). 2020 Jun 12; 9(6). PMID: 32545642.
      Citations: 4     
    15. Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C. Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Proc Natl Acad Sci U S A. 2020 06 09; 117(23):13094-13104. PMID: 32434914.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    16. Craig LB, Brush RS, Sullivan MT, Zavy MT, Agbaga MP, Anderson RE. Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality. J Assist Reprod Genet. 2019 Jul; 36(7):1379-1385. PMID: 31073727.
      Citations: 12     Fields:    Translation:HumansCells
    17. Agbaga MP, Merriman DK, Brush RS, Lydic TA, Conley SM, Naash MI, Jackson S, Woods AS, Reid GE, Busik JV, Anderson RE. Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors. J Lipid Res. 2018 09; 59(9):1586-1596. PMID: 29986998.
      Citations: 26     Fields:    Translation:AnimalsCells
    18. Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CSR, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RVS. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240. PMID: 29445082.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    19. Schori C, Agbaga MP, Brush RS, Ayyagari R, Grimm C, Samardzija M. Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse. PLoS One. 2018; 13(1):e0190514. PMID: 29293603.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2018 02; 55(2):1795-1813. PMID: 29168048.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Hopiavuori BR, Agbaga MP, Brush RS, Sullivan MT, Sonntag WE, Anderson RE. Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint. J Lipid Res. 2017 04; 58(4):668-680. PMID: 28202633.
      Citations: 17     Fields:    Translation:Animals
    22. Hopiavuori BR, Masser DR, Wilkerson JL, Brush RS, Mandal NA, Anderson RE, Freeman WM. Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods Mol Biol. 2017; 1609:33-41. PMID: 28660571.
      Citations: 2     Fields:    Translation:Cells
    23. Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Hum Mol Genet. 2016 Apr 01; 25(7):1345-56. PMID: 26908598.
      Citations: 15     Fields:    Translation:AnimalsCells
    24. Azadi S, Brush RS, Anderson RE, Rajala RV. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Adv Exp Med Biol. 2016; 854:363-9. PMID: 26427433.
      Citations: 2     Fields:    Translation:AnimalsCells
    25. Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA. PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One. 2015; 10(12):e0145305. PMID: 26694648.
      Citations: 5     Fields:    Translation:Animals
    26. Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage. 2014 Sep; 22(9):1301-9. PMID: 25008209.
      Citations: 18     Fields:    Translation:Animals
    27. Mandal NA, Tran JT, Zheng L, Wilkerson JL, Brush RS, McRae J, Agbaga MP, Zhang K, Petrukhin K, Ayyagari R, Anderson RE. In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. Invest Ophthalmol Vis Sci. 2014 Apr 25; 55(4):2705-13. PMID: 24644051.
      Citations: 6     Fields:    Translation:HumansAnimals
    28. Bennett LD, Hopiavuori BR, Brush RS, Chan M, Van Hook MJ, Thoreson WB, Anderson RE. Examination of VLC-PUFA-deficient photoreceptor terminals. Invest Ophthalmol Vis Sci. 2014 Apr 24; 55(7):4063-72. PMID: 24764063.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Bennett LD, Brush RS, Chan M, Lydic TA, Reese K, Reid GE, Busik JV, Elliott MH, Anderson RE. Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest Ophthalmol Vis Sci. 2014 Apr 10; 55(5):3150-7. PMID: 24722693.
      Citations: 22     Fields:    Translation:AnimalsCells
    30. Logan S, Agbaga MP, Chan MD, Brush RS, Anderson RE. Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity. J Lipid Res. 2014 Apr; 55(4):698-708. PMID: 24569140.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Agbaga MP, Logan S, Brush RS, Anderson RE. Biosynthesis of very long-chain polyunsaturated fatty acids in hepatocytes expressing ELOVL4. Adv Exp Med Biol. 2014; 801:631-6. PMID: 24664752.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    32. Marchette LD, Sherry DM, Brush RS, Chan M, Wen Y, Wang J, Ash JD, Anderson RE, Mandal NA. Very long chain polyunsaturated fatty acids and rod cell structure and function. Adv Exp Med Biol. 2014; 801:637-45. PMID: 24664753.
      Citations: 6     Fields:    Translation:AnimalsCells
    33. Logan S, Agbaga MP, Chan MD, Kabir N, Mandal NA, Brush RS, Anderson RE. Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5446-51. PMID: 23509295.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    34. Chen H, Tran JA, Eckerd A, Huynh TP, Elliott MH, Brush RS, Mandal NA. Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration. J Lipid Res. 2013 Jun; 54(6):1616-1629. PMID: 23468130.
      Citations: 29     Fields:    Translation:Animals
    35. Mohammed A, Janakiram NB, Brewer M, Duff A, Lightfoot S, Brush RS, Anderson RE, Rao CV. Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice. Neoplasia. 2012 Dec; 14(12):1249-59. PMID: 23308056.
      Citations: 30     Fields:    Translation:AnimalsCells
    36. Chen H, Tran JT, Brush RS, Saadi A, Rahman AK, Yu M, Yasumura D, Matthes MT, Ahern K, Yang H, LaVail MM, Mandal MN. Ceramide signaling in retinal degeneration. Adv Exp Med Biol. 2012; 723:553-8. PMID: 22183377.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    37. Yu M, Benham A, Logan S, Brush RS, Mandal MNA, Anderson RE, Agbaga MP. ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3. J Lipid Res. 2012 Mar; 53(3):494-504. PMID: 22158834.
      Citations: 33     Fields:    Translation:AnimalsCells
    38. Li F, Marchette LD, Brush RS, Elliott MH, Davis KR, Anderson AG, Anderson RE. High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol Vis. 2010 Aug 18; 16:1669-79. PMID: 20806040.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Brush RS, Tran JT, Henry KR, McClellan ME, Elliott MH, Mandal MN. Retinal sphingolipids and their very-long-chain fatty acid-containing species. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4422-31. PMID: 20393115.
      Citations: 29     Fields:    Translation:AnimalsCells
    40. Agbaga MP, Brush RS, Mandal MN, Elliott MH, Al-Ubaidi MR, Anderson RE. Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid. Adv Exp Med Biol. 2010; 664:233-42. PMID: 20238022.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol. 2010; 664:567-73. PMID: 20238060.
      Citations: 3     Fields:    Translation:Animals
    42. Roqueta-Rivera M, Stroud CK, Haschek WM, Akare SJ, Segre M, Brush RS, Agbaga MP, Anderson RE, Hess RA, Nakamura MT. Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. J Lipid Res. 2010 Feb; 51(2):360-7. PMID: 19690334.
      Citations: 53     Fields:    Translation:AnimalsCells
    43. Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem. 2009 Sep; 110(5):1648-60. PMID: 19575708.
      Citations: 3     Fields:    Translation:AnimalsCells
    44. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303.
      Citations: 23     Fields:    Translation:HumansAnimals
    45. Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL. Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J. 2009 Feb; 96(3):939-50. PMID: 19186132.
      Citations: 54     Fields:    Translation:AnimalsCells
    46. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res. 2009 May; 50(5):807-19. PMID: 19023138.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    47. Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12843-8. PMID: 18728184.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    48. Karpac J, Czyzewska K, Kern A, Brush RS, Anderson RE, Hochgeschwender U. Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E446-55. PMID: 18559987.
      Citations: 2     Fields:    Translation:AnimalsCells
    49. Boesze-Battaglia K, Damek-Poprawa M, Mitchell DC, Greeley L, Brush RS, Anderson RE, Richards MJ, Fliesler SJ. Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome. J Lipid Res. 2008 Jul; 49(7):1488-99. PMID: 18344409.
      Citations: 16     Fields:    Translation:AnimalsCells
    50. Ford DA, Monda JK, Brush RS, Anderson RE, Richards MJ, Fliesler SJ. Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species. J Neurochem. 2008 May; 105(3):1032-47. PMID: 18182048.
      Citations: 35     Fields:    Translation:AnimalsCells
    51. Makino CL, Wen XH, Michaud N, Peshenko IV, Pawlyk B, Brush RS, Soloviev M, Liu X, Woodruff ML, Calvert PD, Savchenko AB, Anderson RE, Fain GL, Li T, Sandberg MA, Dizhoor AM. Effects of low AIPL1 expression on phototransduction in rods. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2185-94. PMID: 16639031.
      Citations: 12     Fields:    Translation:AnimalsCells
    52. Martin RE, Fliesler SJ, Brush RS, Richards MJ, Hopkins SA, Anderson RE. Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations. Mol Vis. 2005 May 12; 11:338-46. PMID: 15928607.
      Citations: 7     Fields:    Translation:AnimalsCells
    53. Martin RE, Elliott MH, Brush RS, Anderson RE. Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1147-54. PMID: 15790872.
      Citations: 51     Fields:    Translation:AnimalsCells
    54. Martin RE, Ranchon-Cole I, Brush RS, Williamson CR, Hopkins SA, Li F, Anderson RE. P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration. Mol Vis. 2004 Mar 26; 10:199-207. PMID: 15064683.
      Citations: 6     Fields:    Translation:AnimalsCells
    55. Káldi I, Martin RE, Huang H, Brush RS, Morrison KA, Anderson RE. Bright cyclic rearing protects albino mouse retina against acute light-induced apoptosis. Mol Vis. 2003 Jul 30; 9:337-44. PMID: 12891098.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
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