"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
- Granzyme K
- Natural Killer Cell Granule Tryptase-2
- Natural Killer Cell Granule Tryptase 2
- NK Tryptase 2
- Granzyme 3
- Granzyme A
- Cytotoxic T-Lymphocyte Proteinase 1
- Cytotoxic T Lymphocyte Proteinase 1
- Hanukah Factor
- Granzyme B
- Fragmentin 2
- Cytotoxic T-Lymphocyte Associated 1 Protein
- Cytotoxic T Lymphocyte Associated 1 Protein
- Granzyme-Like Protein III
- Granzyme Like Protein III
- Cytotoxic Serine Protease B
Below are MeSH descriptors whose meaning is more general than "Granzymes".
Below are MeSH descriptors whose meaning is more specific than "Granzymes".
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Below are the most recent publications written about "Granzymes" by people in Profiles.
Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis. 2007 Apr 15; 195(8):1126-36.
Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol. 2007 Apr; 81(8):3704-13.
Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity. Neoplasia. 2006 Feb; 8(2):125-35.