"Factor XIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
| Descriptor ID |
D015956
|
| MeSH Number(s) |
D08.811.277.656.300.760.324 D08.811.277.656.959.350.324 D12.776.124.125.450.324 D23.119.450.324
|
| Concept/Terms |
Factor XIIa- Factor XIIa
- Activated Factor XII
- Factor XII, Activated
- Coagulation Factor XIIa
- Factor XIIa, Coagulation
- Blood Coagulation Factor XII, Activated
- Prekallikrein Activator
- Activator, Prekallikrein
- Factor Twelve A
- Factor 12A
|
Below are MeSH descriptors whose meaning is more general than "Factor XIIa".
Below are MeSH descriptors whose meaning is more specific than "Factor XIIa".
This graph shows the total number of publications written about "Factor XIIa" by people in this website by year, and whether "Factor XIIa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Factor XIIa" by people in Profiles.
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Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death. Blood Adv. 2019 02 26; 3(4):658-669.
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Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways. Blood. 2018 08 23; 132(8):849-860.