STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
| Descriptor ID |
D050796
|
| MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
|
| Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
|
Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 3 | 4 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 5 | 6 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 4 | 5 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 2 | 3 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
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A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity. Proc Natl Acad Sci U S A. 2025 May 06; 122(18):e2427073122.
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Targeting lactylation and the STAT3/CCL2 axis to overcome immunotherapy resistance in pancreatic ductal adenocarcinoma. J Clin Invest. 2025 Apr 01; 135(7).
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Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility. Int J Mol Sci. 2025 Jan 01; 26(1).
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Stat3 Inhibitors TTI-101 and SH5-07 Suppress Bladder Cancer Cell Survival in 3D Tumor Models. Cells. 2024 Aug 31; 13(17).
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PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy. Elife. 2024 Aug 29; 12.
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Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways. Oncogene. 2021 Aug; 40(31):5002-5012.
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Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism. Mol Cancer Res. 2021 09; 19(9):1534-1545.
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Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress. Int J Mol Sci. 2021 Feb 18; 22(4).
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E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation. J Immunol. 2020 08 15; 205(4):1009-1023.
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Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Lett. 2020 08 01; 484:29-39.