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The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.
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The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.
The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis. Am J Pathol. 2012 Sep; 181(3):858-65.
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PubMed
subject areas
Amino Acid Substitution
Amino Acid Substitution
Animals
Animals
Bone Marrow
Bone Marrow
Disease Models, Animal
Disease Models, Animal
Hematopoiesis, Extramedullary
Hematopoiesis, Extramedullary
Humans
Humans
Hyperplasia
Hyperplasia
Janus Kinase 2
Janus Kinase 2
Megakaryocytes
Megakaryocytes
Mice
Mice
Mice, Inbred C57BL
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Mutant Strains
Myeloid Cells
Myeloid Cells
Phosphorylation
Phosphorylation
Primary Myelofibrosis
Primary Myelofibrosis
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Reticulin
Reticulin
Small Molecule Libraries
Small Molecule Libraries
Spleen
Spleen
Splenomegaly
Splenomegaly
STAT5 Transcription Factor
STAT5 Transcription Factor
Stilbenes
Stilbenes
authors with profiles
Zhizhuang J Zhao